iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045269

UUCD1 version

UUC-GoG-00588

Ensembl Protein ID

ENSGGOP00000014628.2

UniProt Accession

G3RG85; G3RG85_GORGO

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014987.2	ENSGGOT00000015041.2	ENSGGOP00000014628.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	32.0	404	442

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 404  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKIECPICR 442
           ********99.899***************......**********8 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGCGCAGG CGTAGTGCTC CTGCTTCCTG GCCGAGGGCG GGCGAGCGGA GCTCGCAGCG 60
ATCGCGAGCG TGTGGCGATT GCTTCTGTCT GTTATTTAGA TATGGAAGCT GAGGGGATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ggo:101136855

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	84.27	0.00e+00	661.00
IUUC-Apl-003664	Anas platyrhynchos	80.00	2.00e-39	154.00
IUUC-Aca-005036	Anolis carolinensis	57.05	1.00e-120	426.00
IUUC-Ani-009177	Aspergillus nidulans	35.79	9.00e-08	52.00
IUUC-Ame-011537	Astyanax mexicanus	42.65	2.00e-89	322.00
IUUC-Bta-013297	Bos taurus	83.98	0.00e+00	639.00
IUUC-Cel-018658	Caenorhabditis elegans	41.07	2.00e-07	50.80
IUUC-Cja-019201	Callithrix jacchus	90.04	0.00e+00	736.00
IUUC-Cfa-021041	Canis familiaris	85.60	0.00e+00	707.00
IUUC-Csa-024133	Chlorocebus sabaeus	97.94	0.00e+00	854.00
IUUC-Cho-024624	Choloepus hoffmanni	75.37	7.00e-136	476.00
IUUC-Dre-027918	Danio rerio	42.55	4.00e-81	295.00
IUUC-Dno-029774	Dasypus novemcinctus	83.74	0.00e+00	685.00
IUUC-Dor-030190	Dipodomys ordii	72.02	2.00e-150	525.00
IUUC-Ete-032301	Echinops telfairi	67.08	6.00e-142	497.00
IUUC-Eca-033607	Equus caballus	86.22	3.00e-175	607.00
IUUC-Eeu-034888	Erinaceus europaeus	82.06	3.00e-121	428.00
IUUC-Fca-036075	Felis catus	84.16	0.00e+00	710.00
IUUC-Fal-037569	Ficedula albicollis	61.36	7.00e-118	417.00
IUUC-Gmo-038588	Gadus morhua	40.94	2.00e-72	266.00
IUUC-Gga-040777	Gallus gallus	58.60	5.00e-120	424.00
IUUC-Gac-042463	Gasterosteus aculeatus	42.15	7.00e-64	238.00
IUUC-Hsa-046249	Homo sapiens	98.97	0.00e+00	852.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	84.19	0.00e+00	703.00
IUUC-Lch-049805	Latimeria chalumnae	51.06	1.00e-113	403.00
IUUC-Loc-052377	Lepisosteus oculatus	49.05	5.00e-92	331.00
IUUC-Mcc-055344	Macaca mulatta	97.94	0.00e+00	858.00
IUUC-Meu-055950	Macropus eugenii	63.09	7.00e-130	457.00
IUUC-Mla-059052	Melampsora laricipopulina	35.38	1.00e-09	56.20
IUUC-Mga-060049	Meleagris gallopavo	57.84	4.00e-118	418.00
IUUC-Mmr-061431	Microcebus murinus	85.71	0.00e+00	668.00
IUUC-Mdo-062016	Monodelphis domestica	67.87	3.00e-124	440.00
IUUC-Mmu-063235	Mus musculus	71.05	2.00e-178	618.00
IUUC-Mpu-066449	Mustela putorius furo	86.86	0.00e+00	741.00
IUUC-Mlu-067588	Myotis lucifugus	79.92	0.00e+00	629.00
IUUC-Nle-069192	Nomascus leucogenys	99.38	0.00e+00	873.00
IUUC-Opr-070300	Ochotona princeps	63.79	9.00e-142	496.00
IUUC-Ont-071998	Oreochromis niloticus	42.34	8.00e-67	248.00
IUUC-Oan-073610	Ornithorhynchus anatinus	66.09	6.00e-67	246.00
IUUC-Ocu-074603	Oryctolagus cuniculus	79.01	0.00e+00	637.00
IUUC-Ola-086681	Oryzias latipes	39.88	7.00e-70	258.00
IUUC-Oga-088183	Otolemur garnettii	85.57	0.00e+00	723.00
IUUC-Oar-090255	Ovis aries	84.38	3.00e-166	578.00
IUUC-Ptr-091029	Pan troglodytes	97.82	0.00e+00	788.00
IUUC-Pan-092241	Papio anubis	98.15	0.00e+00	862.00
IUUC-Psi-093506	Pelodiscus sinensis	61.07	6.00e-132	464.00
IUUC-Pma-094579	Petromyzon marinus	56.67	2.00e-26	113.00
IUUC-Pfo-097014	Poecilia formosa	42.27	1.00e-63	237.00
IUUC-Pab-098530	Pongo abelii	98.05	0.00e+00	807.00
IUUC-Pca-100939	Procavia capensis	62.14	7.00e-142	496.00
IUUC-Pva-103148	Pteropus vampyrus	78.81	0.00e+00	644.00
IUUC-Rno-105338	Rattus norvegicus	72.90	0.00e+00	641.00
IUUC-Sce-106282	Saccharomyces cerevisiae	33.71	4.00e-06	45.80
IUUC-Sha-107187	Sarcophilus harrisii	66.17	2.00e-106	378.00
IUUC-Sja-107948	Schizosaccharomyces japonicus	22.34	3.00e-09	56.20
IUUC-Sar-113356	Sorex araneus	65.10	6.00e-129	453.00
IUUC-Ssc-116290	Sus scrofa	84.89	0.00e+00	746.00
IUUC-Tru-117910	Takifugu rubripes	41.06	2.00e-61	229.00
IUUC-Tsy-119329	Tarsius syrichta	79.24	4.00e-168	584.00
IUUC-Tni-120521	Tetraodon nigroviridis	39.07	1.00e-61	230.00
IUUC-Tme-126989	Tuber melanosporum	32.76	9.00e-07	48.50
IUUC-Ttr-128997	Tursiops truncatus	79.29	1.00e-180	625.00
IUUC-Vpa-130154	Vicugna pacos	82.72	0.00e+00	699.00
IUUC-Xtr-132805	Xenopus tropicalis	50.94	3.00e-108	385.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence