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Tag Content
UUCD2 ID IUUC-Ssc-116290
UUCD1 version UUC-SuS-00250
Ensembl Protein ID ENSSSCP00000019764.1
UniProt Accession I3L6W2; I3L6W2_PIG
Genbank Protein ID ENSSSCP00000019764
Protein Name E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
Genbank Nucleotide ID CU467025
Gene Name RNF8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000001578.2 ENSSSCT00000001757.2 ENSSSCP00000001712.2
ENSSSCG00000001578.2 ENSSSCT00000028776.1 ENSSSCP00000019764.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.40e-07 31.0 405 443
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       +++  CP+Cr
   Q: 405  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKVECPICR 443
           ********99.899***************......**********8 PP
   
Organism Sus scrofa
Protein Sequence
(Fasta)
MGEPGSLVTG GRAGDRSWCL RRVGMNAEWL LLEDGKEVTV GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNA EGQWTITDNK SLNGVWLNRE RLEPLKVYSI HEGDHIQLGV PLENKENAEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ssc-116290|E3,RING|Sus scrofa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGGGGGCG GAGCCCGAAC GAGCGTTTGC ATCGATCGCG AGCTCCTAGC GATTGCTTCT 60
GTCTGTACTG TTAGTATGGC GTCCGCGAGA AAGCGGAGAG GCGGCGGGAA CTCGGGTCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ssc-116290|E3,RING|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00498--FHA
PF00097--zf-C3HC4
SMART

SM00240--FHA
SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002124 Ailuropoda melanoleuca 87.34 0.00e+00 690.00
IUUC-Apl-003664 Anas platyrhynchos 77.66 2.00e-39 154.00
IUUC-Aca-005036 Anolis carolinensis 56.82 2.00e-119 422.00
IUUC-Ame-011537 Astyanax mexicanus 41.75 1.00e-88 320.00
IUUC-Bta-013297 Bos taurus 89.21 0.00e+00 688.00
IUUC-Cja-019201 Callithrix jacchus 81.33 0.00e+00 649.00
IUUC-Cfa-021041 Canis familiaris 88.41 0.00e+00 729.00
IUUC-Csa-024133 Chlorocebus sabaeus 84.27 0.00e+00 700.00
IUUC-Cho-024624 Choloepus hoffmanni 79.10 3.00e-140 491.00
IUUC-Dre-027918 Danio rerio 42.80 2.00e-83 303.00
IUUC-Dno-029774 Dasypus novemcinctus 86.96 0.00e+00 725.00
IUUC-Dor-030190 Dipodomys ordii 74.79 3.00e-157 548.00
IUUC-Ete-032301 Echinops telfairi 68.38 3.00e-150 524.00
IUUC-Eca-033607 Equus caballus 87.89 2.00e-180 624.00
IUUC-Eeu-034888 Erinaceus europaeus 82.84 3.00e-126 444.00
IUUC-Fca-036075 Felis catus 85.89 0.00e+00 731.00
IUUC-Fal-037569 Ficedula albicollis 63.23 1.00e-121 429.00
IUUC-Gmo-038588 Gadus morhua 40.04 6.00e-76 277.00
IUUC-Gga-040777 Gallus gallus 60.63 4.00e-123 434.00
IUUC-Gac-042463 Gasterosteus aculeatus 41.42 7.00e-64 238.00
IUUC-Ggo-045269 Gorilla gorilla 84.89 0.00e+00 710.00
IUUC-Hsa-046249 Homo sapiens 84.47 0.00e+00 690.00
IUUC-Itr-048314 Ictidomys tridecemlineatus 85.89 0.00e+00 721.00
IUUC-Lch-049805 Latimeria chalumnae 52.77 1.00e-120 426.00
IUUC-Loc-052377 Lepisosteus oculatus 49.79 4.00e-96 344.00
IUUC-Mcc-055344 Macaca mulatta 84.06 0.00e+00 702.00
IUUC-Meu-055950 Macropus eugenii 62.96 2.00e-128 452.00
IUUC-Mor-057012 Magnaporthe oryzae 30.19 3.00e-07 50.40
IUUC-Mga-060049 Meleagris gallopavo 59.36 2.00e-121 429.00
IUUC-Mmr-061431 Microcebus murinus 86.10 0.00e+00 674.00
IUUC-Mdo-062016 Monodelphis domestica 68.10 3.00e-126 446.00
IUUC-Mmu-063368 Mus musculus 73.82 0.00e+00 647.00
IUUC-Mpu-066449 Mustela putorius furo 90.25 0.00e+00 771.00
IUUC-Mlu-067588 Myotis lucifugus 81.33 0.00e+00 640.00
IUUC-Nle-069192 Nomascus leucogenys 84.89 0.00e+00 707.00
IUUC-Opr-070300 Ochotona princeps 65.84 3.00e-151 528.00
IUUC-Ont-071998 Oreochromis niloticus 42.31 2.00e-68 253.00
IUUC-Oan-073610 Ornithorhynchus anatinus 67.11 4.00e-68 250.00
IUUC-Ocu-074603 Oryctolagus cuniculus 81.78 0.00e+00 676.00
IUUC-Ola-086681 Oryzias latipes 40.87 6.00e-74 271.00
IUUC-Oga-088183 Otolemur garnettii 87.14 0.00e+00 722.00
IUUC-Oar-090255 Ovis aries 88.34 7.00e-178 616.00
IUUC-Ptr-091029 Pan troglodytes 83.52 0.00e+00 640.00
IUUC-Pan-092241 Papio anubis 84.27 0.00e+00 706.00
IUUC-Psi-093506 Pelodiscus sinensis 63.64 9.00e-138 483.00
IUUC-Pma-094579 Petromyzon marinus 56.67 7.00e-27 114.00
IUUC-Pfo-097014 Poecilia formosa 42.71 6.00e-68 251.00
IUUC-Pab-098530 Pongo abelii 83.88 0.00e+00 651.00
IUUC-Pca-100939 Procavia capensis 64.18 4.00e-148 517.00
IUUC-Pva-103148 Pteropus vampyrus 81.78 0.00e+00 673.00
IUUC-Rno-105338 Rattus norvegicus 74.53 0.00e+00 660.00
IUUC-Sce-106282 Saccharomyces cerevisiae 29.58 5.00e-07 48.50
IUUC-Sha-107187 Sarcophilus harrisii 66.00 1.00e-104 372.00
IUUC-Sar-113356 Sorex araneus 68.49 2.00e-137 482.00
IUUC-Tru-117910 Takifugu rubripes 41.77 5.00e-66 244.00
IUUC-Tsy-119329 Tarsius syrichta 80.45 4.00e-170 590.00
IUUC-Tni-120521 Tetraodon nigroviridis 39.71 3.00e-64 238.00
IUUC-Tme-126989 Tuber melanosporum 32.76 8.00e-07 48.90
IUUC-Ttr-128997 Tursiops truncatus 83.63 0.00e+00 672.00
IUUC-Vpa-130154 Vicugna pacos 85.77 0.00e+00 741.00
IUUC-Xtr-132805 Xenopus tropicalis 50.20 1.00e-109 389.00
IUUC-Xma-133620 Xiphophorus maculatus 42.89 5.00e-66 244.00
Created Date 25-Jun-2017

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