iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074323

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02029806

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000009234.3	ENSOCUT00000009235.3	ENSOCUP00000007973.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-86	291.2	190	811

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
           +G++NlgNtC++N+v+Q Ls++  l+el++e k++ ++ +                 + g+l+++l  +++++ +++k+  sp+ l+++
   Q: 190  KGITNLGNTCFFNAVIQNLSQTYILTELMNEMKENGTKFKIFpssdsqldplvveLPSPGPLTSALFLFLHSMRETEKGPLSPKVLFNQ 278
           59*****************************44444443332445555555555566666***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclec 159
           l+++a++f+ ++qqD+qE+l++lld +++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+ec
   Q: 279  LCQKAPRFKDFQQQDSQELLHYLLDVVRTEETKRIQASILKAFNNPTTKTADDatrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCEEC 367
           *******************************99999999999998888888884444334445555555******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           +n+s+ ++pf+d+slp+ +++ +k+                                                                
   Q: 368  ANISTMKDPFIDISLPIIEERVSKPVlvgrmskyrssqerdhdqysgvvtmentqqprpakkyssskdknqqihdrkcqrklspaeekt 456
           *********************98777*************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 457  iftyqknadldmdgapsvsagarspnesptdgsgkeascsessveadseasesesaskqagqcrsrgrpcaltdgrlpgppagtlpstk 545
           ***************************************************************************************** PP
   S: 186  ........................................................................slqdcLesftkeeeleg 202
                                                                                   s+q+cL +ft+ e l g
   Q: 546  etdsgdeavanaiselclsspeigdgdldrekqplsipnklgfageehvrphspqhafqtlsqsyittskecSVQSCLYQFTSMELLMG 634
           ***************************************************************************************** PP
   S: 203  enkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekq 272
           +nk+ ce+c++k++                   a+k+l ++ +P++LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ ++++ 
   Q: 635  NNKLLCENCTEKKQrypkeinsaekkaeavytnARKQLLISAVPPILILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSATCKNI 721
           **********99999999999999999999999*********************..9999************************88876 PP
   S: 273  ke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgstaYvl 333
           +   k+ Y+L+++v HsGs+++GHY+ayvk                           + g+W++++D++V++v+e++ l+   ++aY+l
   Q: 722  SMgdKVLYSLYGIVEHSGSMRGGHYTAYVKVrtpsrklseyitgkktvpdvkepdseSVGQWIHVSDTYVQVVPESRALN---AQAYLL 807
           55669**************************999999999999999999998887766788*******************...****** PP
   S: 334  fYkr 337
           fY+r
   Q: 808  FYER 811
           **98 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MRVKDPSKVL PEKAKRSKRP TVPRDEDSSD DIAGLTCQHV SHAVSVNHVK RAVAENLWSV 60
CSECLKERRF FDGQPVLPSD IWLCLKCGFQ GCGKNSESQH SLKHFKSSGP EPHCIVISLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGATAACAG ATGCGGGTGA AAGATCCGTC CAAGGTGTTA CCTGAGAAAG CCAAAAGAAG 60
TAAAAGGCCC ACTGTACCTC GTGATGAGGA CTCTTCAGAT GACATTGCTG GTAAATTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100348405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	72.26	0.00e+00	1083.00
IUUC-Apl-003512	Anas platyrhynchos	65.98	0.00e+00	1051.00
IUUC-Aca-004284	Anolis carolinensis	60.87	0.00e+00	979.00
IUUC-Ame-010735	Astyanax mexicanus	65.11	7.00e-89	320.00
IUUC-Bta-012880	Bos taurus	78.36	0.00e+00	1215.00
IUUC-Cja-019144	Callithrix jacchus	80.81	0.00e+00	1304.00
IUUC-Cfa-020971	Canis familiaris	78.06	0.00e+00	728.00
IUUC-Cpo-022497	Cavia porcellus	69.45	0.00e+00	1068.00
IUUC-Csa-023910	Chlorocebus sabaeus	81.16	0.00e+00	1214.00
IUUC-Cho-024358	Choloepus hoffmanni	61.60	1.00e-113	402.00
IUUC-Dre-028106	Danio rerio	62.29	2.00e-152	533.00
IUUC-Dno-029456	Dasypus novemcinctus	70.78	0.00e+00	661.00
IUUC-Dor-030438	Dipodomys ordii	63.13	0.00e+00	932.00
IUUC-Dme-031870	Drosophila melanogaster	44.16	5.00e-38	153.00
IUUC-Ete-032736	Echinops telfairi	64.21	0.00e+00	944.00
IUUC-Eca-034211	Equus caballus	78.51	0.00e+00	1266.00
IUUC-Eeu-034797	Erinaceus europaeus	75.88	5.00e-86	311.00
IUUC-Fca-035947	Felis catus	76.97	0.00e+00	1136.00
IUUC-Fal-037199	Ficedula albicollis	66.71	0.00e+00	918.00
IUUC-Gmo-039228	Gadus morhua	62.53	2.00e-143	502.00
IUUC-Gga-040823	Gallus gallus	59.33	2.00e-162	565.00
IUUC-Gac-042406	Gasterosteus aculeatus	60.53	1.00e-137	483.00
IUUC-Ggo-045402	Gorilla gorilla	80.59	0.00e+00	1287.00
IUUC-Hsa-046430	Homo sapiens	80.68	0.00e+00	1294.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	78.70	0.00e+00	733.00
IUUC-Lch-049547	Latimeria chalumnae	57.30	0.00e+00	910.00
IUUC-Loc-052842	Lepisosteus oculatus	58.12	0.00e+00	903.00
IUUC-Laf-053988	Loxodonta africana	79.76	0.00e+00	1289.00
IUUC-Mcc-055491	Macaca mulatta	77.26	0.00e+00	1222.00
IUUC-Meu-056256	Macropus eugenii	59.74	1.00e-166	579.00
IUUC-Mtr-057945	Medicago truncatula	30.96	2.00e-33	138.00
IUUC-Mla-059026	Melampsora laricipopulina	32.04	1.00e-16	81.60
IUUC-Mga-059833	Meleagris gallopavo	56.52	5.00e-166	577.00
IUUC-Mmr-060952	Microcebus murinus	79.19	0.00e+00	1271.00
IUUC-Mdo-062642	Monodelphis domestica	68.07	0.00e+00	1048.00
IUUC-Mmu-063945	Mus musculus	77.15	0.00e+00	1216.00
IUUC-Mpu-065944	Mustela putorius furo	74.91	0.00e+00	1152.00
IUUC-Mlu-067049	Myotis lucifugus	78.29	0.00e+00	1212.00
IUUC-Nle-069828	Nomascus leucogenys	80.95	0.00e+00	1293.00
IUUC-Opr-070672	Ochotona princeps	74.86	1.00e-147	517.00
IUUC-Ont-072121	Oreochromis niloticus	60.55	3.00e-138	485.00
IUUC-Oan-073656	Ornithorhynchus anatinus	65.01	0.00e+00	1021.00
IUUC-Ola-087238	Oryzias latipes	54.12	3.00e-150	525.00
IUUC-Oga-088379	Otolemur garnettii	75.06	0.00e+00	1184.00
IUUC-Oar-089718	Ovis aries	78.29	0.00e+00	1210.00
IUUC-Ptr-091358	Pan troglodytes	80.81	0.00e+00	1295.00
IUUC-Pan-092023	Papio anubis	81.54	0.00e+00	1300.00
IUUC-Psi-093256	Pelodiscus sinensis	64.57	0.00e+00	990.00
IUUC-Ppa-095584	Physcomitrella patens	27.54	2.00e-34	141.00
IUUC-Pfo-097285	Poecilia formosa	52.71	6.00e-121	428.00
IUUC-Pab-098539	Pongo abelii	81.17	0.00e+00	1302.00
IUUC-Pca-100610	Procavia capensis	66.03	0.00e+00	904.00
IUUC-Pva-102985	Pteropus vampyrus	73.72	0.00e+00	1161.00
IUUC-Rno-105538	Rattus norvegicus	76.04	0.00e+00	1209.00
IUUC-Sha-107022	Sarcophilus harrisii	69.93	4.00e-176	611.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	29.83	1.00e-20	95.10
IUUC-Spo-108149	Schizosaccharomyces pombe	30.29	1.00e-21	99.00
IUUC-Sar-113637	Sorex araneus	66.26	0.00e+00	1020.00
IUUC-Ssc-115870	Sus scrofa	78.85	0.00e+00	1282.00
IUUC-Tgu-116907	Taeniopygia guttata	65.24	0.00e+00	1052.00
IUUC-Tru-117835	Takifugu rubripes	52.01	5.00e-110	392.00
IUUC-Tsy-118869	Tarsius syrichta	78.16	0.00e+00	1102.00
IUUC-Tni-119716	Tetraodon nigroviridis	56.03	5.00e-93	335.00
IUUC-Tbe-128041	Tupaia belangeri	66.02	0.00e+00	865.00
IUUC-Ttr-128901	Tursiops truncatus	76.89	0.00e+00	1224.00
IUUC-Vpa-130331	Vicugna pacos	78.32	0.00e+00	1147.00
IUUC-Xtr-131794	Xenopus tropicalis	64.69	5.00e-142	498.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence