iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005105

Ensembl Protein ID

ENSACAP00000010275.1

UniProt Accession

G1KK46; G1KK46_ANOCA

Protein Name

Uncharacterized protein

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000010466.2	ENSACAT00000010487.2	ENSACAP00000010275.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.10e-44	148.3	196	253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+ +g+ Gl+P+n+v 
   Q: 196  VLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNSRGQIGLVPKNYVI 253
           5789**************************************.7*************96 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANKTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEYP SNGSSADRIY DLNIPAYVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATATTGCAA GCATAATTTT GCTCAAGGCG TAACTTTTAC TGTCTAGATC CTGCGTTGTG 60
CCAAAGGTGA GTTTGTTTGG ATTTATTTAA ATTGACATTG ATAGTCTGTC AGTTTTCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

acs:100557091

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	91.58	0.00e+00	719.00
IUUC-Apl-003456	Anas platyrhynchos	97.37	0.00e+00	750.00
IUUC-Ame-010966	Astyanax mexicanus	77.86	1.00e-175	608.00
IUUC-Bta-012424	Bos taurus	84.74	0.00e+00	632.00
IUUC-Cel-018144	Caenorhabditis elegans	42.16	7.00e-76	277.00
IUUC-Cja-019898	Callithrix jacchus	91.84	0.00e+00	722.00
IUUC-Cfa-020830	Canis familiaris	90.53	0.00e+00	714.00
IUUC-Cpo-021487	Cavia porcellus	84.07	0.00e+00	637.00
IUUC-Csa-023693	Chlorocebus sabaeus	92.37	0.00e+00	725.00
IUUC-Cho-024368	Choloepus hoffmanni	65.52	2.00e-131	461.00
IUUC-Cin-025348	Ciona intestinalis	38.08	5.00e-67	248.00
IUUC-Csv-026046	Ciona savignyi	39.05	3.00e-69	255.00
IUUC-Dre-028334	Danio rerio	81.72	1.00e-180	625.00
IUUC-Dno-028973	Dasypus novemcinctus	92.11	0.00e+00	719.00
IUUC-Dor-031003	Dipodomys ordii	89.74	0.00e+00	679.00
IUUC-Dme-031846	Drosophila melanogaster	40.83	3.00e-88	318.00
IUUC-Ete-032792	Echinops telfairi	84.11	0.00e+00	650.00
IUUC-Eca-033656	Equus caballus	91.84	0.00e+00	721.00
IUUC-Eeu-034743	Erinaceus europaeus	63.52	3.00e-139	488.00
IUUC-Fca-036347	Felis catus	91.84	0.00e+00	720.00
IUUC-Fal-037095	Ficedula albicollis	97.11	0.00e+00	749.00
IUUC-Gmo-039410	Gadus morhua	69.64	1.00e-160	558.00
IUUC-Gga-040155	Gallus gallus	97.37	0.00e+00	749.00
IUUC-Gac-041787	Gasterosteus aculeatus	71.93	1.00e-166	578.00
IUUC-Ggo-044805	Gorilla gorilla	92.11	0.00e+00	723.00
IUUC-Hsa-046585	Homo sapiens	92.11	0.00e+00	723.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	90.53	0.00e+00	696.00
IUUC-Lch-049795	Latimeria chalumnae	91.84	0.00e+00	711.00
IUUC-Loc-051985	Lepisosteus oculatus	90.79	0.00e+00	683.00
IUUC-Laf-054228	Loxodonta africana	93.95	0.00e+00	727.00
IUUC-Mcc-055402	Macaca mulatta	92.37	0.00e+00	725.00
IUUC-Meu-056139	Macropus eugenii	65.35	4.00e-143	500.00
IUUC-Mga-059374	Meleagris gallopavo	97.37	0.00e+00	749.00
IUUC-Mmr-061453	Microcebus murinus	91.84	0.00e+00	721.00
IUUC-Mdo-063080	Monodelphis domestica	96.32	0.00e+00	744.00
IUUC-Mmu-063529	Mus musculus	88.68	0.00e+00	691.00
IUUC-Mpu-066815	Mustela putorius furo	91.58	0.00e+00	719.00
IUUC-Mlu-067132	Myotis lucifugus	87.87	9.00e-157	545.00
IUUC-Nle-069371	Nomascus leucogenys	92.11	0.00e+00	723.00
IUUC-Opr-070948	Ochotona princeps	91.51	0.00e+00	682.00
IUUC-Ont-071410	Oreochromis niloticus	74.06	1.00e-163	568.00
IUUC-Oan-073304	Ornithorhynchus anatinus	94.77	1.00e-167	582.00
IUUC-Ocu-074783	Oryctolagus cuniculus	91.58	0.00e+00	705.00
IUUC-Ola-086808	Oryzias latipes	72.75	5.00e-160	556.00
IUUC-Oga-088391	Otolemur garnettii	92.11	0.00e+00	708.00
IUUC-Oar-090025	Ovis aries	79.74	4.00e-166	576.00
IUUC-Ptr-090975	Pan troglodytes	92.11	0.00e+00	723.00
IUUC-Pan-092287	Papio anubis	92.37	0.00e+00	725.00
IUUC-Psi-093413	Pelodiscus sinensis	96.84	0.00e+00	746.00
IUUC-Pfo-097129	Poecilia formosa	75.70	1.00e-169	588.00
IUUC-Pab-098756	Pongo abelii	92.11	0.00e+00	723.00
IUUC-Pca-100235	Procavia capensis	80.79	0.00e+00	634.00
IUUC-Pva-102294	Pteropus vampyrus	88.16	0.00e+00	687.00
IUUC-Rno-105090	Rattus norvegicus	88.68	0.00e+00	691.00
IUUC-Sha-107521	Sarcophilus harrisii	96.32	0.00e+00	746.00
IUUC-Sar-113697	Sorex araneus	84.38	0.00e+00	648.00
IUUC-Ssc-115958	Sus scrofa	83.86	2.00e-163	568.00
IUUC-Tgu-116559	Taeniopygia guttata	95.26	0.00e+00	724.00
IUUC-Tru-117677	Takifugu rubripes	75.44	2.00e-166	578.00
IUUC-Tsy-119184	Tarsius syrichta	62.36	7.00e-127	446.00
IUUC-Tni-120434	Tetraodon nigroviridis	75.45	6.00e-164	570.00
IUUC-Tbe-127931	Tupaia belangeri	90.19	3.00e-175	606.00
IUUC-Ttr-128993	Tursiops truncatus	84.47	0.00e+00	638.00
IUUC-Vpa-130344	Vicugna pacos	68.50	3.00e-155	541.00
IUUC-Xtr-132543	Xenopus tropicalis	86.61	0.00e+00	681.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence