iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-092986

Ensembl Protein ID

ENSPSIP00000011184.1

UniProt Accession

K7FT24; K7FT24_PELSI

Genbank Protein ID

ENSPSIP00000011184

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01047537

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000010091.1	ENSPSIT00000011240.1	ENSPSIP00000011184.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-57	195.1	343	671

Active Site

Position(s)	Description	Evidence
641	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 9    levefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrlld 89
           +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ +++  ++d+++ np  +++  +e++G+l+g al+ +++l 
   Q: 343  WECKFIAEGIIDQGGGFRDSLADMSEELCPSSaespvpLPFFVRTSNQGNSTGEARDMYIPNPscKEFAKYEWIGQLMGAALRGKEFLV 431
           45*****************************9999*99**********************999999999******************** PP
   S: 90   lplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYv 174
            p   ++ +   +++l + +d ++vd+ l+k l+ ++ +     ++++++++f    + +++l++++ +eL+p+G ++ V +e+++e++
   Q: 432  SPAGGALAQAPRSRDLXWgKDSPAVDSVLVKLLEVMEVM-----DQETFEFKFGkelTYTTVLSDQRMVELIPNGGSTVVRYEDRQEFI 515
           *************************************77.....445566666633445566999************************ PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +lv ++rl+e  keq++a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++lkk t++++ +++++  +q+Fwe+l++f++ e   
   Q: 516  RLVQKARLEE-SKEQIAAMQAGLLRVVPQAVLDLLTWQELEKKVCGDPEVTVDALKKLTRFED-FESSDTRVQYFWEALSNFTNGEPPL 602
           *********9.9*************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgG.faelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             +   g+   P  G +a l+ +   ++ ++++d lP+s+TC + L LP+Y + ++++ekL+yA  ++ +++
   Q: 603  PYRHGPGCRVSPQPGpLAWLP-K--SLPSSETTDALPESSTCSSSLYLPNYATAKVCEEKLRYAAYNCVAID 671
           *********999866155555.5..5666789**********************************998776 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

RWEQVVDLTY SLRLGAKPKA MEPDEAAVQK LRGVPPTWSY ECDEDLVRFL YDHLGKEDEN 60
LGSVKQYVES IDVSSYTVRG AGACRSALRC DAVAARPGFA PGREGCVLTV VTHVMVCLLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTGGGAGC AGGTGGTGGA TCTGACGTAC TCCCTGCGGC TCGGTGCCAA GCCCAAGGCC 60
ATGGAGCCGG ACGAGGCGGC GGTGCAGAAG CTCCGGTAGC AGCACGGCCC GTGGCGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	72.86	0.00e+00	999.00
IUUC-Apl-003715	Anas platyrhynchos	78.52	0.00e+00	1056.00
IUUC-Aca-004377	Anolis carolinensis	75.33	0.00e+00	1013.00
IUUC-Ame-011918	Astyanax mexicanus	61.85	0.00e+00	810.00
IUUC-Bta-012736	Bos taurus	72.86	0.00e+00	1000.00
IUUC-Cja-019926	Callithrix jacchus	72.71	0.00e+00	1000.00
IUUC-Cfa-020753	Canis familiaris	75.87	0.00e+00	889.00
IUUC-Cpo-021415	Cavia porcellus	72.86	0.00e+00	1003.00
IUUC-Csa-023096	Chlorocebus sabaeus	72.57	0.00e+00	999.00
IUUC-Dre-028746	Danio rerio	66.95	0.00e+00	875.00
IUUC-Dno-029293	Dasypus novemcinctus	78.46	0.00e+00	865.00
IUUC-Dor-031113	Dipodomys ordii	75.87	0.00e+00	889.00
IUUC-Ete-032601	Echinops telfairi	67.34	0.00e+00	889.00
IUUC-Eca-034198	Equus caballus	72.71	0.00e+00	996.00
IUUC-Eeu-034708	Erinaceus europaeus	77.83	0.00e+00	719.00
IUUC-Fca-035478	Felis catus	72.86	0.00e+00	1002.00
IUUC-Fal-037366	Ficedula albicollis	76.92	0.00e+00	1037.00
IUUC-Gmo-039020	Gadus morhua	66.36	0.00e+00	861.00
IUUC-Gga-040332	Gallus gallus	78.23	0.00e+00	1040.00
IUUC-Gac-042336	Gasterosteus aculeatus	67.39	0.00e+00	921.00
IUUC-Ggo-045382	Gorilla gorilla	72.71	0.00e+00	999.00
IUUC-Hsa-046562	Homo sapiens	72.71	0.00e+00	999.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	72.86	0.00e+00	1001.00
IUUC-Lch-049606	Latimeria chalumnae	62.97	0.00e+00	702.00
IUUC-Loc-052448	Lepisosteus oculatus	60.37	0.00e+00	790.00
IUUC-Laf-054507	Loxodonta africana	72.46	0.00e+00	993.00
IUUC-Mcc-055690	Macaca mulatta	72.57	0.00e+00	999.00
IUUC-Meu-055970	Macropus eugenii	72.71	0.00e+00	972.00
IUUC-Mga-059654	Meleagris gallopavo	78.37	0.00e+00	1049.00
IUUC-Mmr-061069	Microcebus murinus	72.57	0.00e+00	998.00
IUUC-Mdo-062547	Monodelphis domestica	79.58	0.00e+00	662.00
IUUC-Mmu-063096	Mus musculus	72.57	0.00e+00	1000.00
IUUC-Mpu-065846	Mustela putorius furo	73.00	0.00e+00	1001.00
IUUC-Mlu-067992	Myotis lucifugus	73.15	0.00e+00	1003.00
IUUC-Nle-069565	Nomascus leucogenys	73.97	0.00e+00	910.00
IUUC-Opr-070853	Ochotona princeps	71.23	0.00e+00	727.00
IUUC-Ont-071628	Oreochromis niloticus	68.02	0.00e+00	897.00
IUUC-Ocu-074094	Oryctolagus cuniculus	72.86	0.00e+00	1001.00
IUUC-Ola-087384	Oryzias latipes	66.76	0.00e+00	912.00
IUUC-Oga-088224	Otolemur garnettii	72.86	0.00e+00	1006.00
IUUC-Oar-090043	Ovis aries	72.86	0.00e+00	1001.00
IUUC-Ptr-090852	Pan troglodytes	72.57	0.00e+00	997.00
IUUC-Pan-092787	Papio anubis	72.57	0.00e+00	998.00
IUUC-Pma-094416	Petromyzon marinus	36.31	1.00e-118	421.00
IUUC-Pfo-096720	Poecilia formosa	67.05	0.00e+00	927.00
IUUC-Pab-098325	Pongo abelii	71.63	0.00e+00	724.00
IUUC-Pca-100885	Procavia capensis	64.53	0.00e+00	846.00
IUUC-Pva-102829	Pteropus vampyrus	57.87	9.00e-148	517.00
IUUC-Rno-104882	Rattus norvegicus	72.86	0.00e+00	1000.00
IUUC-Sha-106811	Sarcophilus harrisii	82.08	3.00e-107	381.00
IUUC-Sar-113020	Sorex araneus	80.49	4.00e-138	485.00
IUUC-Ssc-115436	Sus scrofa	64.15	4.00e-91	327.00
IUUC-Tgu-117042	Taeniopygia guttata	77.50	0.00e+00	1041.00
IUUC-Tru-118419	Takifugu rubripes	66.37	0.00e+00	856.00
IUUC-Tsy-118829	Tarsius syrichta	70.50	7.00e-166	577.00
IUUC-Tni-120410	Tetraodon nigroviridis	54.69	0.00e+00	657.00
IUUC-Tbe-128113	Tupaia belangeri	77.46	7.00e-174	603.00
IUUC-Ttr-128167	Tursiops truncatus	71.55	0.00e+00	964.00
IUUC-Xtr-132910	Xenopus tropicalis	66.04	0.00e+00	846.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence