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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064246
UUCD1 version UUC-MuM-00817
Ensembl Protein ID ENSMUSP00000040896.3
UniProt Accession Q8VHQ2; B1AQY1; Q3UH08; SOCS7_MOUSE
Genbank Protein ID AAL60516.1; BAE28006.1; BAE28049.1; CAM15701.1
Protein Name Suppressor of cytokine signaling 7
Genbank Nucleotide ID AF424814; AK147580; AK147650; AL596088
Gene Name Socs7; Cish7; Nap4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038485.5 ENSMUST00000045540.3 ENSMUSP00000040896.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.00e-13 52.1 504 551
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           +++ +++s++ SLqhLCR++Ir++++++++   + LPLPk L++Y++++ y
   Q: 504  LYPVSRFSNVKSLQHLCRFRIRQLVRIDHI---PDLPLPKPLISYIRKFYY 551
           567899*********************998...*************99976 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
 Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Protein Sequence
(Fasta)
MVFRNVGRPP EEEDAEAARE PGPSELLCPR HRCALDPKAL PPGLALERTW GPVAGLEAQL 60
AALGLGQPAG PGIKTAGGGC CPCPCPPQPP PPQPPPPAAA PQAGEDPTET SDALLVLEGL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064246|E3,SOCS|Mus musculus
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Nucleotide Sequence
(Fasta)
GCCGCCGCCC CCGGGCCACA GCCATGGCCC GTCGCCGCCA CCACCCTTCC TCGCGCGGCC 60
CGGCTCGCGG GGCGCCCGGC CGCCTCAGCT GATGGTGTTC CGCAACGTGG GGCGGCCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064246|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0341--Growth regulation
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028423--SOCS7
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0021799--P:cerebral cortex radially oriented cell migration
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0021819--P:layer formation in cerebral cortex
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0021942--P:radial glia guided migration of Purkinje cell
GO:0040008--P:regulation of growth
KEGG mmu:192157
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001668 Ailuropoda melanoleuca 90.95 0.00e+00 661.00
IUUC-Apl-003277 Anas platyrhynchos 91.78 7.00e-73 265.00
IUUC-Aca-004639 Anolis carolinensis 97.28 5.00e-108 382.00
IUUC-Ame-011301 Astyanax mexicanus 70.26 1.00e-130 459.00
IUUC-Bta-013483 Bos taurus 95.69 0.00e+00 731.00
IUUC-Cja-019765 Callithrix jacchus 99.69 2.00e-163 568.00
IUUC-Cfa-020109 Canis familiaris 97.88 0.00e+00 649.00
IUUC-Cpo-021555 Cavia porcellus 95.76 5.00e-177 613.00
IUUC-Csa-023580 Chlorocebus sabaeus 94.50 0.00e+00 713.00
IUUC-Cho-024431 Choloepus hoffmanni 99.21 5.00e-72 264.00
IUUC-Dre-028183 Danio rerio 70.45 2.00e-138 486.00
IUUC-Dno-028858 Dasypus novemcinctus 93.44 0.00e+00 714.00
IUUC-Dor-031071 Dipodomys ordii 79.25 4.00e-114 404.00
IUUC-Dme-031876 Drosophila melanogaster 43.65 4.00e-43 170.00
IUUC-Ete-032928 Echinops telfairi 70.55 7.00e-101 361.00
IUUC-Eca-033250 Equus caballus 92.91 2.00e-175 607.00
IUUC-Eeu-034946 Erinaceus europaeus 83.91 3.00e-52 199.00
IUUC-Fca-036589 Felis catus 94.70 0.00e+00 643.00
IUUC-Fal-037316 Ficedula albicollis 93.07 5.00e-112 396.00
IUUC-Gmo-038552 Gadus morhua 91.26 2.00e-53 201.00
IUUC-Gga-041248 Gallus gallus 96.76 7.00e-108 382.00
IUUC-Gac-041469 Gasterosteus aculeatus 83.47 9.00e-57 211.00
IUUC-Ggo-045282 Gorilla gorilla 99.37 1.00e-162 565.00
IUUC-Hsa-045926 Homo sapiens 94.33 0.00e+00 712.00
IUUC-Itr-048411 Ictidomys tridecemlineatus 95.75 9.00e-166 576.00
IUUC-Lch-049768 Latimeria chalumnae 71.28 4.00e-153 534.00
IUUC-Loc-051949 Lepisosteus oculatus 74.05 2.00e-128 453.00
IUUC-Laf-053410 Loxodonta africana 89.41 0.00e+00 687.00
IUUC-Mcc-054605 Macaca mulatta 87.72 0.00e+00 684.00
IUUC-Meu-056773 Macropus eugenii 80.19 5.00e-107 380.00
IUUC-Mmr-060927 Microcebus murinus 94.13 0.00e+00 708.00
IUUC-Mdo-061892 Monodelphis domestica 87.66 2.00e-175 608.00
IUUC-Mpu-065995 Mustela putorius furo 98.14 0.00e+00 629.00
IUUC-Mlu-067526 Myotis lucifugus 89.98 0.00e+00 710.00
IUUC-Nle-069317 Nomascus leucogenys 97.62 9.00e-163 566.00
IUUC-Ont-072258 Oreochromis niloticus 66.49 2.00e-116 413.00
IUUC-Oan-073703 Ornithorhynchus anatinus 80.49 1.00e-36 143.00
IUUC-Ocu-074577 Oryctolagus cuniculus 90.92 0.00e+00 741.00
IUUC-Oga-088426 Otolemur garnettii 92.23 0.00e+00 701.00
IUUC-Oar-089407 Ovis aries 95.80 0.00e+00 656.00
IUUC-Ptr-091327 Pan troglodytes 98.67 0.00e+00 631.00
IUUC-Pan-092064 Papio anubis 98.67 0.00e+00 644.00
IUUC-Psi-093834 Pelodiscus sinensis 94.36 1.00e-153 535.00
IUUC-Pfo-097100 Poecilia formosa 60.96 4.00e-115 409.00
IUUC-Pab-097695 Pongo abelii 89.98 0.00e+00 687.00
IUUC-Pca-100569 Procavia capensis 89.87 4.00e-169 587.00
IUUC-Pva-102784 Pteropus vampyrus 94.13 0.00e+00 699.00
IUUC-Ptt-103775 Puccinia triticina 38.46 1.60e+00 28.50
IUUC-Rno-105485 Rattus norvegicus 95.16 0.00e+00 733.00
IUUC-Sha-106720 Sarcophilus harrisii 93.14 2.00e-172 598.00
IUUC-Sar-112975 Sorex araneus 84.28 6.00e-128 450.00
IUUC-Ssc-116369 Sus scrofa 95.19 0.00e+00 716.00
IUUC-Tgu-116867 Taeniopygia guttata 86.52 6.00e-125 440.00
IUUC-Tru-117562 Takifugu rubripes 77.53 7.00e-101 360.00
IUUC-Tsy-118999 Tarsius syrichta 93.40 5.00e-146 509.00
IUUC-Tni-120793 Tetraodon nigroviridis 57.85 2.00e-129 455.00
IUUC-Tbe-127671 Tupaia belangeri 99.07 1.00e-128 452.00
IUUC-Ttr-128491 Tursiops truncatus 78.46 2.00e-129 455.00
IUUC-Vpa-130104 Vicugna pacos 90.10 1.00e-175 609.00
IUUC-Xtr-132507 Xenopus tropicalis 80.05 4.00e-144 504.00
Created Date 25-Jun-2017

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