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Tag Content
UUCD2 ID IUUC-Aml-002097
UUCD1 version UUC-AiM-00097
Ensembl Protein ID ENSAMEP00000011753.1
UniProt Accession D2HEW7; KLH22_AILME
Genbank Protein ID EFB29357.1
Protein Name Kelch-like protein 22
Genbank Nucleotide ID GL192766
Gene Name KLHL22; PANDA_009375
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000011165.1 ENSAMET00000012251.1 ENSAMEP00000011753.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.10e-19 69.7 51 115
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 9.70e-08 31.3 150 179
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lvv+g++++ah+i Laas+++F+ +f ++l+e++ +++v i++v++ ++ ++l+F+Yt++l++
   Q: 51   DVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEME-QEEVLIHGVSYNAMCQILHFIYTSELEL 115
           9***********************************8.*************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
           eN l+++r+A+l+d+++L ++ +++ilk+F
   Q: 150  ENILDVYRLAELFDLSRLTEQLDTYILKNF 179
           8***************************** PP
   
Organism Ailuropoda melanoleuca
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (By similarity).
Protein Sequence
(Fasta)
MAEEQEFTQL CKLPVQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH 60
IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-002097|E3,BTB_3-box|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGGAGG AGCAGGAGTT CACCCAGCTG TGCAAGTTGC CTGTGCAGCC CTCACACCCA 60
CATTGTGTCA ACAACACCTA CCGGAGTGCA CAGCACTCCC AGGCCTTGCT CCGGGGGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-002097|E3,BTB_3-box|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030575--KLHL22
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005813--C:centrosome
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0072686--C:mitotic spindle
GO:0005827--C:polar microtubule
GO:0051301--P:cell division
GO:0000070--P:mitotic sister chromatid segregation
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0006513--P:protein monoubiquitination
KEGG aml:100471441
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004081 Anas platyrhynchos 77.27 0.00e+00 1021.00
IUUC-Aca-005015 Anolis carolinensis 65.81 0.00e+00 847.00
IUUC-Ame-011712 Astyanax mexicanus 59.70 0.00e+00 721.00
IUUC-Bta-012594 Bos taurus 94.01 0.00e+00 1226.00
IUUC-Cja-019752 Callithrix jacchus 96.63 0.00e+00 1029.00
IUUC-Cfa-020884 Canis familiaris 99.53 0.00e+00 1315.00
IUUC-Cpo-021711 Cavia porcellus 96.53 0.00e+00 1263.00
IUUC-Csa-023211 Chlorocebus sabaeus 97.79 0.00e+00 1274.00
IUUC-Dre-028395 Danio rerio 59.90 0.00e+00 751.00
IUUC-Dno-030096 Dasypus novemcinctus 93.89 0.00e+00 1227.00
IUUC-Dor-030709 Dipodomys ordii 95.95 0.00e+00 707.00
IUUC-Eca-033388 Equus caballus 98.26 0.00e+00 1301.00
IUUC-Eeu-034616 Erinaceus europaeus 85.49 0.00e+00 1098.00
IUUC-Fca-035815 Felis catus 99.37 0.00e+00 1315.00
IUUC-Fal-037311 Ficedula albicollis 79.51 0.00e+00 1001.00
IUUC-Gmo-039571 Gadus morhua 52.26 3.00e-157 548.00
IUUC-Gga-040992 Gallus gallus 77.12 0.00e+00 1020.00
IUUC-Gac-042041 Gasterosteus aculeatus 55.17 0.00e+00 680.00
IUUC-Ggo-045141 Gorilla gorilla 92.11 0.00e+00 1198.00
IUUC-Hsa-045984 Homo sapiens 97.95 0.00e+00 1276.00
IUUC-Itr-048890 Ictidomys tridecemlineatus 97.95 0.00e+00 1277.00
IUUC-Lch-049700 Latimeria chalumnae 60.38 0.00e+00 728.00
IUUC-Loc-052141 Lepisosteus oculatus 61.20 0.00e+00 805.00
IUUC-Laf-053487 Loxodonta africana 95.40 0.00e+00 1231.00
IUUC-Mcc-054682 Macaca mulatta 97.47 0.00e+00 1021.00
IUUC-Meu-055937 Macropus eugenii 74.61 0.00e+00 971.00
IUUC-Mga-059953 Meleagris gallopavo 77.12 0.00e+00 1020.00
IUUC-Mmr-061743 Microcebus murinus 97.63 0.00e+00 1268.00
IUUC-Mdo-062328 Monodelphis domestica 82.76 0.00e+00 1092.00
IUUC-Mmu-063979 Mus musculus 93.78 0.00e+00 1215.00
IUUC-Mpu-066750 Mustela putorius furo 98.74 0.00e+00 1307.00
IUUC-Mlu-066960 Myotis lucifugus 95.43 0.00e+00 1240.00
IUUC-Nle-069690 Nomascus leucogenys 97.85 0.00e+00 1142.00
IUUC-Opr-071059 Ochotona princeps 89.92 0.00e+00 1150.00
IUUC-Ont-072004 Oreochromis niloticus 57.63 0.00e+00 680.00
IUUC-Oan-073172 Ornithorhynchus anatinus 63.08 0.00e+00 739.00
IUUC-Ocu-074310 Oryctolagus cuniculus 96.21 2.00e-155 540.00
IUUC-Ola-086599 Oryzias latipes 57.19 0.00e+00 695.00
IUUC-Oga-087980 Otolemur garnettii 97.32 0.00e+00 1264.00
IUUC-Oar-089956 Ovis aries 78.66 0.00e+00 917.00
IUUC-Ptr-090598 Pan troglodytes 97.67 0.00e+00 1145.00
IUUC-Pan-092387 Papio anubis 97.28 0.00e+00 1021.00
IUUC-Psi-093484 Pelodiscus sinensis 78.84 0.00e+00 1050.00
IUUC-Pma-094224 Petromyzon marinus 49.59 5.00e-171 594.00
IUUC-Pfo-096149 Poecilia formosa 57.63 0.00e+00 709.00
IUUC-Pab-098097 Pongo abelii 97.79 0.00e+00 1277.00
IUUC-Pca-100118 Procavia capensis 95.95 0.00e+00 704.00
IUUC-Pva-103174 Pteropus vampyrus 96.96 1.00e-157 550.00
IUUC-Rno-105350 Rattus norvegicus 94.32 0.00e+00 1203.00
IUUC-Sha-106817 Sarcophilus harrisii 82.77 2.00e-135 475.00
IUUC-Sar-113490 Sorex araneus 96.21 0.00e+00 651.00
IUUC-Ssc-115827 Sus scrofa 95.74 0.00e+00 1253.00
IUUC-Tgu-116748 Taeniopygia guttata 81.75 0.00e+00 896.00
IUUC-Tru-118644 Takifugu rubripes 57.49 0.00e+00 689.00
IUUC-Tsy-118888 Tarsius syrichta 90.86 0.00e+00 1040.00
IUUC-Tni-120060 Tetraodon nigroviridis 53.93 1.00e-173 603.00
IUUC-Ttr-129183 Tursiops truncatus 95.16 0.00e+00 1116.00
IUUC-Xtr-132780 Xenopus tropicalis 68.68 0.00e+00 902.00
Created Date 25-Jun-2017

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