iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000093131.3	ENSDART00000135186.3	ENSDARP00000120215.2
ENSDARG00000093131.3	ENSDART00000159329.1	ENSDARP00000131884.1
ENSDARG00000093131.3	ENSDART00000158877.1	ENSDARP00000131708.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-33	117.6	481	806

Active Site

Position(s)	Description	Evidence
775	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++r+ ++f++     Ee++dlgG+ refl ll+ +l +++  +f  +e ++ +l  +++++    ++ ++F  +Gr ++++l++g + +
   Q: 481  NNRMVIRFSDdkgkfEEAVDLGGPRREFLRLLLVALMESS--MFDGKE-GSINLALDSQAM----REDRYF-IAGRAVAVSLVHGGPAP 561
           578889999999999***********************99..884333.333444444443....566777.89*************** PP
   S: 90   lplsksfyklllgk....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYv 174
             +sk++y  l++     +  led+   dpe+y  +k+++e   s +ee  l  + +    i+   ++     g+ +   ++++k++ v
   Q: 562  GCFSKTLYDSLVQGpdmcRPGLEDV--ADPEIYSKIKKLSEA--STVEE--LRESTE---PIMDFLANA----GCLRPIKNIDDKDRLV 637
           *************943333455554..59***********77..34444..444433...344555554....5555555789****** PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketky.....kggytedspaiqwFwevl.eefs 257
           ++++ + + ++++  +e fr+G++++  l +++   e+  +l+++  ++++++++ +  +       ++  ++++ ++ Fw+ + ++++
   Q: 638  EDLLMFQVVNRVRGPFERFRDGLKTLGVLAKVQQHPESFRSLFCHQPKQLTADMMDDLFEIqwseiGSNKRANENRVIAFWRDYlQDVE 726
           **********************************99999999999999**9999998775555644555667888899***85449999 PP
   S: 258  seerkaf...LqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +e  +++   L F+Tgs+ +P+ Gf + + + +  + d++  +r+P +nTC+n+L+LP Ys++  +k+++ +Ai++t gF++
   Q: 727  EEGAQRLgaiLSFTTGSDHVPPIGFHPQP-S-IAFHHDSELlQRFPIANTCINCLRLPLYSTYGAFKSNMEFAINNTHGFGK 806
           987775444499**************988.5.5555544445**************************************97 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MHLVCLPAAI NQKIRRSKLD FTTFLHLTTM NSDSANLTDA INILRNVLAS PTIIRSISNS 60
VDSNASPSAE LQTETESELR NLFRPSRAQS IRQSMSAGEG PRYHTRQQYG NWQSRSRKRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAATCTA TCCTATCGTT AAGCTTATGA AATATAAATA ATGTGATTAA TTGAGGTATT 60
AAGTTTTTTG ATTATTGAAA ACATGACATG ACTGCTCCAG CAAAATGTTT ATTAAAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:101883039

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gmo-039715	Gadus morhua	58.02	6.00e-135	473.00
IUUC-Meu-056753	Macropus eugenii	34.72	2.00e-39	157.00
IUUC-Opr-071224	Ochotona princeps	42.44	2.00e-59	223.00
IUUC-Ont-071340	Oreochromis niloticus	40.71	3.00e-83	302.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence