iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062824

UUCD1 version

UUC-MoD-00810

Ensembl Protein ID

ENSMODP00000006326.2

UniProt Accession

F7EQF4; F7EQF4_MONDO

Protein Name

Uncharacterized protein

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000005140.2	ENSMODT00000006458.2	ENSMODP00000006326.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.20e-13	49.1	166	213

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l++ ++r+Lq+LCR++I+ ++g+++l    k+PL+++LkdYL+++++q
   Q: 166  VTPLRQLRVRPLQELCRKSIVATFGRDNL---GKIPLNPVLKDYLKSFPFQ 213
           56789999*********************...****************986 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MVAHSKVAAD NAVTADTRRR LDPSPSPPSH RAGREHPSPQ PRPQHGLAPQ HGAGDTHFRT 60
FRSQADYFSI TRASALLDAC GFYWGPLSVN VAHEKLKGEP VGTFLVRDSR QKNCFFAISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAGTAAGGT GGCAGCCGAC AATGCAGTTA CAGCAGACAC AAGAAGAAGA 60
CTCGACCCTT CTCCTTCTCC TCCATCCCAC AGGGCTGGCC GGGAACATCC CAGCCCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	72.89	1.00e-67	248.00
IUUC-Apl-003313	Anas platyrhynchos	73.36	7.00e-88	316.00
IUUC-Aca-005109	Anolis carolinensis	59.04	3.00e-63	234.00
IUUC-Ame-011550	Astyanax mexicanus	53.75	6.00e-52	196.00
IUUC-Bta-013411	Bos taurus	81.37	8.00e-78	282.00
IUUC-Cja-019595	Callithrix jacchus	69.77	1.00e-78	285.00
IUUC-Cfa-020563	Canis familiaris	80.75	3.00e-77	280.00
IUUC-Cpo-021374	Cavia porcellus	67.74	6.00e-78	283.00
IUUC-Csa-023333	Chlorocebus sabaeus	70.56	2.00e-79	288.00
IUUC-Dre-028507	Danio rerio	43.13	1.00e-46	178.00
IUUC-Dno-029406	Dasypus novemcinctus	68.22	2.00e-78	285.00
IUUC-Ete-032399	Echinops telfairi	66.36	5.00e-77	280.00
IUUC-Eca-033519	Equus caballus	68.22	8.00e-76	276.00
IUUC-Fal-036726	Ficedula albicollis	73.83	3.00e-85	307.00
IUUC-Gmo-039667	Gadus morhua	43.36	2.00e-23	102.00
IUUC-Gga-040970	Gallus gallus	73.83	4.00e-88	316.00
IUUC-Gac-041838	Gasterosteus aculeatus	40.00	7.00e-37	146.00
IUUC-Ggo-045569	Gorilla gorilla	66.36	1.00e-78	285.00
IUUC-Hsa-046010	Homo sapiens	68.69	1.00e-78	285.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	81.99	6.00e-78	283.00
IUUC-Lch-050219	Latimeria chalumnae	64.56	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	54.67	4.00e-63	233.00
IUUC-Laf-054219	Loxodonta africana	78.68	2.00e-60	223.00
IUUC-Mcc-054830	Macaca mulatta	70.70	1.00e-79	288.00
IUUC-Meu-056565	Macropus eugenii	87.85	7.00e-104	369.00
IUUC-Mga-060153	Meleagris gallopavo	71.50	3.00e-85	307.00
IUUC-Mmr-061365	Microcebus murinus	81.99	4.00e-78	283.00
IUUC-Mmu-064120	Mus musculus	80.75	4.00e-77	280.00
IUUC-Mpu-066839	Mustela putorius furo	68.52	2.00e-78	284.00
IUUC-Mlu-067829	Myotis lucifugus	80.75	4.00e-77	280.00
IUUC-Nle-069592	Nomascus leucogenys	68.22	1.00e-75	275.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	1.00e-37	149.00
IUUC-Oan-073586	Ornithorhynchus anatinus	48.60	1.00e-23	102.00
IUUC-Ocu-073996	Oryctolagus cuniculus	81.99	7.00e-78	282.00
IUUC-Ola-087158	Oryzias latipes	46.88	3.00e-39	154.00
IUUC-Oga-088076	Otolemur garnettii	69.16	4.00e-79	287.00
IUUC-Ptr-091241	Pan troglodytes	68.69	5.00e-79	286.00
IUUC-Pan-091836	Papio anubis	67.29	3.00e-79	287.00
IUUC-Psi-093628	Pelodiscus sinensis	75.58	6.00e-91	326.00
IUUC-Pfo-097501	Poecilia formosa	40.80	1.00e-35	142.00
IUUC-Pab-098170	Pongo abelii	70.56	2.00e-78	285.00
IUUC-Pop-100072	Populus trichocarpa	33.33	1.00e-02	33.90
IUUC-Pva-102796	Pteropus vampyrus	69.63	5.00e-78	283.00
IUUC-Rno-105319	Rattus norvegicus	80.75	4.00e-77	280.00
IUUC-Sha-107201	Sarcophilus harrisii	99.35	1.00e-88	317.00
IUUC-Ssc-116004	Sus scrofa	66.52	4.00e-79	287.00
IUUC-Tgu-116836	Taeniopygia guttata	72.90	8.00e-88	315.00
IUUC-Tru-118090	Takifugu rubripes	43.12	3.00e-35	141.00
IUUC-Tni-120719	Tetraodon nigroviridis	44.38	2.00e-31	129.00
IUUC-Vpa-130235	Vicugna pacos	70.23	4.00e-78	283.00
IUUC-Xtr-132610	Xenopus tropicalis	64.52	2.00e-76	278.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence