iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088076

Ensembl Protein ID

ENSOGAP00000021005.1

UniProt Accession

H0XY12; H0XY12_OTOGA

Genbank Protein ID

ENSOGAP00000021005

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03167652

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000034069.1	ENSOGAT00000034251.1	ENSOGAP00000021005.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.00e-13	50.0	164	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 164  GTPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 211
           57899************************...***************9986 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MVAHNQVAAD NAISTAPEPR RRPEPSSSSS SSSPAAPARP RPCLAVPTPA PGDTHFRTFR 60
SQADYRRITR TSALLDACGF YWGPLSVHGA HERLRTEPVG TFLVRDSRQR NCFFTLSVKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAACCAGGT GGCAGCTGAC AATGCAATCT CCACGGCACC AGAGCCCCGA 60
CGGCGGCCAG AGCCTTCATC CTCGTCTTCC TCCTCCTCTC CCGCGGCCCC GGCGCGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	86.14	2.00e-77	280.00
IUUC-Apl-003313	Anas platyrhynchos	61.79	4.00e-72	263.00
IUUC-Aca-005109	Anolis carolinensis	68.35	2.00e-63	234.00
IUUC-Ame-011550	Astyanax mexicanus	51.25	1.00e-49	189.00
IUUC-Bta-013411	Bos taurus	84.75	2.00e-91	328.00
IUUC-Cja-019595	Callithrix jacchus	89.62	4.00e-94	337.00
IUUC-Cfa-020563	Canis familiaris	95.65	4.00e-89	320.00
IUUC-Cpo-021374	Cavia porcellus	86.64	2.00e-93	334.00
IUUC-Csa-023333	Chlorocebus sabaeus	88.26	2.00e-93	334.00
IUUC-Dre-028507	Danio rerio	48.08	2.00e-45	174.00
IUUC-Dno-029406	Dasypus novemcinctus	89.62	1.00e-92	331.00
IUUC-Ete-032399	Echinops telfairi	87.74	8.00e-91	325.00
IUUC-Eca-033519	Equus caballus	85.38	3.00e-87	313.00
IUUC-Fal-036726	Ficedula albicollis	62.74	7.00e-74	269.00
IUUC-Gmo-039667	Gadus morhua	50.44	6.00e-27	113.00
IUUC-Gga-040970	Gallus gallus	62.26	4.00e-73	267.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.45	6.00e-37	146.00
IUUC-Ggo-045569	Gorilla gorilla	86.79	1.00e-92	332.00
IUUC-Hsa-046010	Homo sapiens	91.04	6.00e-92	329.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	96.89	7.00e-90	322.00
IUUC-Lch-050219	Latimeria chalumnae	62.11	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	59.75	4.00e-56	210.00
IUUC-Laf-054219	Loxodonta africana	94.85	2.00e-71	260.00
IUUC-Mcc-054830	Macaca mulatta	87.44	3.00e-93	333.00
IUUC-Meu-056565	Macropus eugenii	72.64	2.00e-81	294.00
IUUC-Mga-060153	Meleagris gallopavo	61.32	4.00e-71	260.00
IUUC-Mmr-061365	Microcebus murinus	85.84	7.00e-91	326.00
IUUC-Mdo-062824	Monodelphis domestica	69.16	2.00e-79	288.00
IUUC-Mmu-064120	Mus musculus	93.40	9.00e-92	328.00
IUUC-Mpu-066839	Mustela putorius furo	87.50	8.00e-93	332.00
IUUC-Mlu-067829	Myotis lucifugus	90.57	6.00e-90	322.00
IUUC-Nle-069592	Nomascus leucogenys	86.79	7.00e-88	316.00
IUUC-Ont-072173	Oreochromis niloticus	45.78	2.00e-39	154.00
IUUC-Oan-073586	Ornithorhynchus anatinus	51.75	8.00e-26	108.00
IUUC-Ocu-073996	Oryctolagus cuniculus	96.89	6.00e-90	322.00
IUUC-Oba-075150	Oryza barthii	31.76	1.20e-02	32.70
IUUC-Oni-082023	Oryza nivara	29.10	2.60e-01	30.80
IUUC-Ola-087158	Oryzias latipes	47.50	1.00e-40	159.00
IUUC-Ptr-091241	Pan troglodytes	91.51	4.00e-93	333.00
IUUC-Pan-091836	Papio anubis	87.74	3.00e-93	333.00
IUUC-Psi-093628	Pelodiscus sinensis	65.57	2.00e-74	271.00
IUUC-Pfo-097501	Poecilia formosa	46.54	5.00e-38	150.00
IUUC-Pab-098170	Pongo abelii	87.79	9.00e-92	328.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.10e-02	33.90
IUUC-Pva-102796	Pteropus vampyrus	87.79	1.00e-91	328.00
IUUC-Rno-105319	Rattus norvegicus	93.87	9.00e-92	328.00
IUUC-Sha-107201	Sarcophilus harrisii	81.17	3.00e-74	270.00
IUUC-Ssc-116004	Sus scrofa	85.45	5.00e-92	330.00
IUUC-Tgu-116836	Taeniopygia guttata	71.78	7.00e-72	263.00
IUUC-Tru-118090	Takifugu rubripes	45.00	1.00e-37	149.00
IUUC-Tni-120719	Tetraodon nigroviridis	45.00	6.00e-33	133.00
IUUC-Vpa-130235	Vicugna pacos	87.44	1.00e-91	328.00
IUUC-Xtr-132610	Xenopus tropicalis	55.19	1.00e-65	241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence