iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003535

Ensembl Protein ID

ENSAPLP00000010124.1

UniProt Accession

R0JV21; R0JV21_ANAPL

Genbank Protein ID

EOB01361.1

Protein Name

Putative E3 ubiquitin-protein ligase HERC3

Genbank Nucleotide ID

ADON01073819

Gene Name

HERC3; Anapl_07453

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000010277.1	ENSAPLT00000010831.1	ENSAPLP00000010124.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-95	318.8	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYPESNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNFTVVDL 807
           899**********************************************999777554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl++++++  +diee+ ++l+f++  e++g t++++L+++G+ni V ++N+ee+v+++
   Q: 808  HFPLALYKKLLNVKPCLEDLKELSPTEGRSLQQLLDYPGEDIEET-FCLNFTICRESYGVTEQKNLIEDGDNILVQKDNREEFVEAY 893
           *******************************************98.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ +i+e ++af+ Gf +v+  ++l+lF++ el+ +i G++++++e+l++ + ykg+yt+++p++++Fwe++++f  e++k+f
   Q: 894  VNYIFNLSIHEWYTAFSTGFLKVCGGKVLELFQPTELRAMIVGNSNYNWEELEESAVYKGDYTATHPTVRMFWETFHAFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil  +L  Ai++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMSSLR---IVIQStASGEQYLPVAHTCYNLLDLPKYSSKEILSARLVQAIDHYEGFSL 1049
           *******************...8888867788**************************************97 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MLCWGYSSFG QPGIGSNLQV IIPEPQVYGF IHDRNVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHES EGSKPEQIGA LAGQHIVHVA CGESHSVALS DQGQLFSWGA GSDGQLGLTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTATGCT GGGGTTACTC GTCTTTTGGA CAGCCTGGGA TAGGTAGCAA CCTCCAGGTC 60
ATCATTCCTG AACCGCAGGT GTACGGGTTC ATCCATGACA GAAACGTCAA GGAGGTGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

apla:101794869

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	88.38	0.00e+00	1875.00
IUUC-Aca-005223	Anolis carolinensis	89.14	0.00e+00	1885.00
IUUC-Ame-010816	Astyanax mexicanus	67.15	0.00e+00	1169.00
IUUC-Bta-013373	Bos taurus	88.38	0.00e+00	1879.00
IUUC-Cel-018150	Caenorhabditis elegans	34.26	2.00e-155	543.00
IUUC-Cja-019609	Callithrix jacchus	88.00	0.00e+00	1868.00
IUUC-Cfa-021071	Canis familiaris	88.19	0.00e+00	1869.00
IUUC-Cpo-021548	Cavia porcellus	87.24	0.00e+00	1857.00
IUUC-Csa-023987	Chlorocebus sabaeus	88.48	0.00e+00	1876.00
IUUC-Cho-024325	Choloepus hoffmanni	90.05	0.00e+00	1106.00
IUUC-Dre-027472	Danio rerio	67.40	0.00e+00	1410.00
IUUC-Dno-029241	Dasypus novemcinctus	87.55	0.00e+00	1856.00
IUUC-Dor-030672	Dipodomys ordii	80.85	0.00e+00	986.00
IUUC-Ete-032642	Echinops telfairi	83.71	0.00e+00	1712.00
IUUC-Eca-033646	Equus caballus	88.48	0.00e+00	1874.00
IUUC-Eeu-035098	Erinaceus europaeus	77.47	0.00e+00	1242.00
IUUC-Fal-036952	Ficedula albicollis	98.76	0.00e+00	2080.00
IUUC-Gmo-039297	Gadus morhua	65.71	0.00e+00	1334.00
IUUC-Gga-040591	Gallus gallus	98.10	0.00e+00	2062.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.94	0.00e+00	1386.00
IUUC-Ggo-044769	Gorilla gorilla	88.01	0.00e+00	1868.00
IUUC-Hsa-046066	Homo sapiens	88.29	0.00e+00	1872.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	87.82	0.00e+00	1865.00
IUUC-Lch-050301	Latimeria chalumnae	74.19	0.00e+00	1618.00
IUUC-Loc-052803	Lepisosteus oculatus	67.81	0.00e+00	1454.00
IUUC-Laf-053364	Loxodonta africana	88.10	0.00e+00	1867.00
IUUC-Mcc-054930	Macaca mulatta	88.38	0.00e+00	1876.00
IUUC-Meu-056274	Macropus eugenii	75.96	0.00e+00	827.00
IUUC-Mtr-058277	Medicago truncatula	37.91	3.00e-52	199.00
IUUC-Mga-059563	Meleagris gallopavo	98.76	0.00e+00	2079.00
IUUC-Mmr-060792	Microcebus murinus	87.05	0.00e+00	1830.00
IUUC-Mdo-062195	Monodelphis domestica	89.63	0.00e+00	1901.00
IUUC-Mmu-063855	Mus musculus	86.57	0.00e+00	1846.00
IUUC-Mpu-066308	Mustela putorius furo	88.48	0.00e+00	1874.00
IUUC-Mlu-066927	Myotis lucifugus	88.19	0.00e+00	1866.00
IUUC-Nle-070090	Nomascus leucogenys	88.29	0.00e+00	1875.00
IUUC-Opr-070891	Ochotona princeps	77.43	0.00e+00	1590.00
IUUC-Ont-072201	Oreochromis niloticus	64.53	0.00e+00	1337.00
IUUC-Ocu-074770	Oryctolagus cuniculus	88.29	0.00e+00	1873.00
IUUC-Ola-086550	Oryzias latipes	65.15	0.00e+00	1379.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.13	6.00e-43	167.00
IUUC-Oga-088831	Otolemur garnettii	88.00	0.00e+00	1869.00
IUUC-Oar-090449	Ovis aries	88.48	0.00e+00	1872.00
IUUC-Pan-092135	Papio anubis	88.39	0.00e+00	1872.00
IUUC-Psi-093832	Pelodiscus sinensis	90.10	0.00e+00	1935.00
IUUC-Pfo-097268	Poecilia formosa	65.81	0.00e+00	1381.00
IUUC-Pab-098249	Pongo abelii	88.00	0.00e+00	1867.00
IUUC-Pca-100855	Procavia capensis	83.88	0.00e+00	1274.00
IUUC-Pva-102506	Pteropus vampyrus	80.59	0.00e+00	1640.00
IUUC-Rno-105242	Rattus norvegicus	86.76	0.00e+00	1882.00
IUUC-Sha-107186	Sarcophilus harrisii	86.42	0.00e+00	1154.00
IUUC-Sar-113612	Sorex araneus	90.28	0.00e+00	702.00
IUUC-Ssc-115473	Sus scrofa	88.10	0.00e+00	1862.00
IUUC-Tgu-116974	Taeniopygia guttata	98.00	0.00e+00	2044.00
IUUC-Tru-118077	Takifugu rubripes	64.59	0.00e+00	1317.00
IUUC-Tsy-119619	Tarsius syrichta	77.52	0.00e+00	1645.00
IUUC-Tni-120807	Tetraodon nigroviridis	65.09	0.00e+00	1340.00
IUUC-Tbe-127640	Tupaia belangeri	84.19	0.00e+00	1741.00
IUUC-Ttr-129172	Tursiops truncatus	87.62	0.00e+00	1854.00
IUUC-Vpa-130442	Vicugna pacos	73.73	0.00e+00	1502.00
IUUC-Xtr-132194	Xenopus tropicalis	71.32	0.00e+00	1417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence