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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046412
UUCD1 version UUC-HoS-00193
Ensembl Protein ID ENSP00000366395.3
UniProt Accession Q86TM6; Q8N3K3; Q8N6E8; Q96JL5; Q96PK3; SYVN1_HUMAN
Genbank Protein ID BAC24801.1; BAC57449.1; AAL26903.1; BAB47439.1; CAD38937.1; AAH30530.1
Protein Name E3 ubiquitin-protein ligase synoviolin; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1
Genbank Nucleotide ID AB085847; AB024690; AF317634; AB058713; AL834262; BC030530
Gene Name SYVN1; HRD1; KIAA1810
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162298.17 ENST00000294256.12 ENSP00000294256.8
ENSG00000162298.17 ENST00000377190.7 ENSP00000366395.3
ENSG00000162298.17 ENST00000307289.10 ENSP00000302035.6
ENSG00000162298.17 ENST00000532771.5 ENSP00000432166.1
ENSG00000162298.17 ENST00000527142.5 ENSP00000432888.1
ENSG00000162298.17 ENST00000528487.1 ENSP00000431720.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
TRANSFACmiRWalkRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19835843; 21149444; 17141218; 14593114; 16847254; 17582219; 18369366; 20606367
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.00e-09 37.7 291 330
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e++ +g + lpC+H+fh++Cl  w       +++++CP+Cr
   Q: 291  CIICREEMVTGAKRLPCNHIFHTSCLRSW------FQRQQTCPTCR 330
           ********99999****************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
 Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Protein Sequence
(Fasta)
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV 60
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA 120
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Protein Fasta Sequence


>IUUC-Hsa-046412|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGGGGGTGGG GAGTGTTGTT AACCGGAGGG GCAGCCGCAG TCGCGCGGAT TGAGCGGGCT 60
CGCGGCGCTG GGTTCCTGGT GAGTGGGGCG AAGTCTGGCC CGAGTTGTGG TTGGGGTCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046412|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0346--Stress response
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032832--E3_lig_synoviolin/Hrd1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005790--C:smooth endoplasmic reticulum
GO:0051117--F:ATPase binding
GO:0051087--F:chaperone binding
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0036503--P:ERAD pathway
GO:0036498--P:IRE1-mediated unfolded protein response
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:84447
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000344 Aegilops tauschii 37.28 4.00e-52 198.00
IUUC-Aml-001539 Ailuropoda melanoleuca 99.70 0.00e+00 706.00
IUUC-Atr-002892 Amborella trichopoda 44.48 9.00e-78 284.00
IUUC-Apl-004003 Anas platyrhynchos 95.76 1.00e-65 240.00
IUUC-Aca-004799 Anolis carolinensis 97.81 0.00e+00 662.00
IUUC-Aly-006352 Arabidopsis lyrata 44.41 3.00e-75 275.00
IUUC-Ath-006773 Arabidopsis thaliana 44.41 7.00e-75 274.00
IUUC-Ago-007894 Ashbya gossypii 25.16 3.00e-18 87.00
IUUC-Acl-008041 Aspergillus clavatus 30.53 1.00e-55 211.00
IUUC-Afl-008427 Aspergillus flavus 31.28 2.00e-50 194.00
IUUC-Afu-009023 Aspergillus fumigatus 31.36 2.00e-56 214.00
IUUC-Ani-009133 Aspergillus nidulans 31.50 1.00e-58 221.00
IUUC-Ang-009612 Aspergillus niger 34.30 7.00e-56 212.00
IUUC-Aor-010045 Aspergillus oryzae 30.94 9.00e-57 215.00
IUUC-Ate-010533 Aspergillus terreus 31.83 2.00e-56 214.00
IUUC-Ame-011083 Astyanax mexicanus 93.38 0.00e+00 630.00
IUUC-Bgr-012122 Blumeria graminis 28.54 2.00e-48 187.00
IUUC-Bta-013375 Bos taurus 100.00 0.00e+00 703.00
IUUC-Bci-013675 Botrytis cinerea 37.25 2.00e-23 104.00
IUUC-Bdi-015070 Brachypodium distachyon 42.69 5.00e-69 255.00
IUUC-Bol-015674 Brassica oleracea 43.50 5.00e-75 275.00
IUUC-Bra-017516 Brassica rapa 43.20 5.00e-73 268.00
IUUC-Cel-018422 Caenorhabditis elegans 57.70 2.00e-117 416.00
IUUC-Cja-019779 Callithrix jacchus 97.35 0.00e+00 672.00
IUUC-Cfa-020189 Canis familiaris 100.00 0.00e+00 703.00
IUUC-Cpo-022209 Cavia porcellus 99.70 0.00e+00 703.00
IUUC-Cre-022743 Chlamydomonas reinhardtii 39.24 3.00e-64 238.00
IUUC-Csa-023571 Chlorocebus sabaeus 100.00 0.00e+00 702.00
IUUC-Cho-024889 Choloepus hoffmanni 88.43 5.00e-178 617.00
IUUC-Csv-026160 Ciona savignyi 60.23 4.00e-122 431.00
IUUC-Cne-027002 Cryptococcus neoformans 40.90 3.00e-76 280.00
IUUC-Cme-027285 Cyanidioschyzon merolae 35.77 1.00e-50 194.00
IUUC-Dre-027999 Danio rerio 93.06 0.00e+00 637.00
IUUC-Dno-029250 Dasypus novemcinctus 99.70 0.00e+00 707.00
IUUC-Dor-030718 Dipodomys ordii 95.27 0.00e+00 669.00
IUUC-Dse-031498 Dothistroma septosporum 34.76 2.00e-27 117.00
IUUC-Dme-031969 Drosophila melanogaster 66.06 6.00e-143 501.00
IUUC-Ete-032592 Echinops telfairi 98.46 8.00e-32 131.00
IUUC-Eca-033258 Equus caballus 100.00 0.00e+00 707.00
IUUC-Fca-035980 Felis catus 99.70 0.00e+00 703.00
IUUC-Fal-037554 Ficedula albicollis 68.86 2.00e-99 356.00
IUUC-Fox-037902 Fusarium oxysporum 31.22 3.00e-52 200.00
IUUC-Fso-038418 Fusarium solani 30.71 2.00e-48 187.00
IUUC-Gmo-039288 Gadus morhua 90.55 0.00e+00 628.00
IUUC-Ggr-040076 Gaeumannomyces graminis 31.68 1.00e-50 195.00
IUUC-Gga-040347 Gallus gallus 92.31 2.00e-75 273.00
IUUC-Gac-042347 Gasterosteus aculeatus 92.43 0.00e+00 628.00
IUUC-Gma-044123 Glycine max 44.02 1.00e-74 273.00
IUUC-Ggo-044858 Gorilla gorilla 100.00 0.00e+00 705.00
IUUC-Hvu-047279 Hordeum vulgare 42.99 1.00e-69 256.00
IUUC-Itr-048924 Ictidomys tridecemlineatus 100.00 0.00e+00 701.00
IUUC-Kpa-049117 Komagataella pastoris 29.19 6.00e-31 129.00
IUUC-Lch-049533 Latimeria chalumnae 49.14 3.00e-73 269.00
IUUC-Lpe-051229 Leersia perrieri 32.38 3.00e-34 139.00
IUUC-Loc-052843 Lepisosteus oculatus 93.06 1.00e-121 428.00
IUUC-Lma-052997 Leptosphaeria maculans 33.07 2.00e-60 227.00
IUUC-Laf-053482 Loxodonta africana 100.00 0.00e+00 701.00
IUUC-Mcc-055075 Macaca mulatta 100.00 0.00e+00 708.00
IUUC-Meu-056683 Macropus eugenii 97.72 4.00e-151 528.00
IUUC-Mor-057082 Magnaporthe oryzae 31.34 5.00e-55 209.00
IUUC-Mpo-057573 Magnaporthe poae 30.64 2.00e-50 193.00
IUUC-Mtr-058601 Medicago truncatula 44.71 9.00e-80 291.00
IUUC-Mla-059168 Melampsora laricipopulina 40.95 7.00e-79 288.00
IUUC-Mga-059510 Meleagris gallopavo 98.80 7.00e-47 180.00
IUUC-Mvi-060515 Microbotryum violaceum 39.57 5.00e-66 246.00
IUUC-Mmr-060922 Microcebus murinus 100.00 0.00e+00 704.00
IUUC-Mdo-062491 Monodelphis domestica 98.52 0.00e+00 678.00
IUUC-Mmu-063770 Mus musculus 100.00 0.00e+00 703.00
IUUC-Mac-064789 Musa acuminata 43.50 8.00e-79 288.00
IUUC-Mpu-066107 Mustela putorius furo 99.41 0.00e+00 708.00
IUUC-Mlu-067918 Myotis lucifugus 97.75 0.00e+00 639.00
IUUC-Nfi-068389 Neosartorya fischeri 30.85 7.00e-56 212.00
IUUC-Ncr-068742 Neurospora crassa 32.16 5.00e-49 189.00
IUUC-Nle-069139 Nomascus leucogenys 100.00 0.00e+00 707.00
IUUC-Opr-070898 Ochotona princeps 99.52 3.00e-125 442.00
IUUC-Ont-071991 Oreochromis niloticus 91.08 0.00e+00 641.00
IUUC-Ocu-074065 Oryctolagus cuniculus 99.11 0.00e+00 699.00
IUUC-Oba-075221 Oryza barthii 41.49 9.00e-68 251.00
IUUC-Obr-076914 Oryza brachyantha 42.90 4.00e-64 238.00
IUUC-Ogu-078124 Oryza glumaepatula 41.49 8.00e-68 251.00
IUUC-Oin-080013 Oryza indica 39.82 4.00e-64 239.00
IUUC-Olo-080247 Oryza longistaminata 39.88 2.00e-60 226.00
IUUC-Ome-081769 Oryza meridionalis 42.09 2.00e-70 259.00
IUUC-Oni-082946 Oryza nivara 41.49 8.00e-68 251.00
IUUC-Opu-083268 Oryza punctata 36.13 6.00e-51 195.00
IUUC-Oru-085114 Oryza rufipogon 41.49 8.00e-68 251.00
IUUC-Osa-085829 Oryza sativa 42.09 2.00e-70 259.00
IUUC-Ola-087449 Oryzias latipes 92.70 0.00e+00 629.00
IUUC-Olu-087894 Ostreococcus lucimarinus 42.04 1.00e-73 269.00
IUUC-Oga-089036 Otolemur garnettii 100.00 0.00e+00 702.00
IUUC-Oar-089715 Ovis aries 100.00 0.00e+00 707.00
IUUC-Ptr-091000 Pan troglodytes 100.00 0.00e+00 701.00
IUUC-Pan-092187 Papio anubis 100.00 0.00e+00 706.00
IUUC-Psi-093377 Pelodiscus sinensis 97.04 0.00e+00 628.00
IUUC-Pma-094759 Petromyzon marinus 92.25 2.00e-79 289.00
IUUC-Pno-094883 Phaeosphaeria nodorum 32.62 9.00e-58 218.00
IUUC-Ppa-095684 Physcomitrella patens 44.51 4.00e-71 262.00
IUUC-Pfo-096861 Poecilia formosa 90.21 0.00e+00 635.00
IUUC-Pab-098030 Pongo abelii 100.00 0.00e+00 706.00
IUUC-Pop-099245 Populus trichocarpa 44.14 4.00e-80 292.00
IUUC-Pca-100191 Procavia capensis 96.49 0.00e+00 679.00
IUUC-Ppe-101829 Prunus persica 43.50 2.00e-79 290.00
IUUC-Pva-102689 Pteropus vampyrus 99.70 0.00e+00 708.00
IUUC-Pgr-103286 Puccinia graminis 37.82 2.00e-73 270.00
IUUC-Ptt-103919 Puccinia triticina 38.27 5.00e-72 265.00
IUUC-Pte-104372 Pyrenophora teres 33.50 9.00e-64 238.00
IUUC-Pyt-104456 Pyrenophora triticirepentis 33.25 1.00e-61 231.00
IUUC-Rno-105723 Rattus norvegicus 100.00 0.00e+00 701.00
IUUC-Sce-106348 Saccharomyces cerevisiae 26.25 2.00e-24 107.00
IUUC-Sha-107300 Sarcophilus harrisii 97.01 6.00e-154 537.00
IUUC-Sja-107685 Schizosaccharomyces japonicus 27.79 6.00e-39 155.00
IUUC-Spo-108308 Schizosaccharomyces pombe 29.77 7.00e-39 155.00
IUUC-Ssl-108558 Sclerotinia sclerotiorum 37.25 1.00e-23 105.00
IUUC-Smo-109123 Selaginella moellendorffii 46.69 6.00e-76 278.00
IUUC-Sit-110276 Setaria italica 43.28 7.00e-71 261.00
IUUC-Sly-111819 Solanum lycopersicum 44.82 4.00e-72 265.00
IUUC-Stu-112048 Solanum tuberosum 44.76 1.00e-75 277.00
IUUC-Sbi-114027 Sorghum bicolor 42.39 1.00e-77 284.00
IUUC-Sre-115212 Sporisorium reilianum 36.76 3.00e-63 236.00
IUUC-Ssc-116323 Sus scrofa 99.70 0.00e+00 699.00
IUUC-Tgu-117156 Taeniopygia guttata 94.81 1.00e-39 153.00
IUUC-Tru-118045 Takifugu rubripes 89.85 0.00e+00 636.00
IUUC-Tsy-118823 Tarsius syrichta 86.52 5.00e-160 556.00
IUUC-Tni-120106 Tetraodon nigroviridis 90.51 8.00e-130 457.00
IUUC-Tca-121462 Theobroma cacao 45.51 2.00e-79 289.00
IUUC-Tre-122204 Trichoderma reesei 38.73 1.00e-26 115.00
IUUC-Tvi-122550 Trichoderma virens 30.77 2.00e-50 194.00
IUUC-Tae-125239 Triticum aestivum 43.28 5.00e-72 265.00
IUUC-Tur-126538 Triticum urartu 38.54 3.00e-50 193.00
IUUC-Tme-127197 Tuber melanosporum 40.73 1.00e-67 251.00
IUUC-Tbe-127385 Tupaia belangeri 90.39 0.00e+00 634.00
IUUC-Ttr-128795 Tursiops truncatus 100.00 0.00e+00 706.00
IUUC-Uma-129401 Ustilago maydis 35.31 2.00e-52 201.00
IUUC-Vda-129968 Verticillium dahliae 29.35 7.00e-42 166.00
IUUC-Vvi-130944 Vitis vinifera 46.22 2.00e-79 289.00
IUUC-Xtr-131884 Xenopus tropicalis 94.05 0.00e+00 653.00
IUUC-Xma-133488 Xiphophorus maculatus 90.50 0.00e+00 640.00
IUUC-Yli-134552 Yarrowia lipolytica 25.35 2.00e-35 143.00
IUUC-Zma-135530 Zea mays 43.45 4.00e-67 249.00
Created Date 25-Jun-2017

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