iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071495

Ensembl Protein ID

ENSONIP00000023130.1

UniProt Accession

I3KPT5; I3KPT5_ORENI

Genbank Protein ID

ENSONIP00000023130

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AERX01019676

Gene Name

usp33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000018371.1	ENSONIT00000023150.1	ENSONIP00000023130.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.70e-114	381.0	156	695

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++ lw k++ ++v p++l++ +k+++++f+gy+
   Q: 156  TGLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSDLWhKNRPSYVVPTNLFQGIKAINPMFRGYA 239
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde................................................ 129
           qqD+qEfl++l+dql+eelk++  +p +++ + +  ++++e                                                
   Q: 240  QQDSQEFLRCLMDQLHEELKEQLPEPCDQSHGIAMDDSPEEdnhsqsdndfqscescgsseraenevqggnaliddtneaemlipeqde 328
           *******************9966666666666665555555667777789999999999999*************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 329  iqanrewqkeknmindlyrsgtngitggstgvdidkdvdtttettpiissqgaikvqgrasdcfpdiqmsnttrpqspvpmeghipkms 417
           ***************************************************************************************** PP
   S: 130  ..........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....... 185
                                      ++k +kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+       
   Q: 418  ssppkaasgwpslnpahkkavttfspPKNKRQKKYRSIISDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLhssthqt 506
           ************************998899999********************************************99888******* PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLil 232
                                                     +lqdcL++f++++el+g+n+y+cekckk+++ +k +k+++lPe+L++
   Q: 507  slvkagscgeayapqgwiafvmeyikrcvynpyvswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKMQSLPEILCI 595
           ***************************************************************************************** PP
   S: 233  hLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevke 319
           hLkRf  ++e ++++ki+++v+fple Ldl+pf+++++++q  +++Y+L++v++H+G++s+GHY+ay++n+ ++ W++fdD++Vtev+e
   Q: 596  HLKRF--RHELMFSTKISTHVSFPLEgLDLQPFLAKDSSAQ--TTSYDLLSVICHHGTASNGHYIAYCRNDVNNlWYEFDDQSVTEVSE 680
           *****..9999*************************88877..9**************************88889************** PP
   S: 320  eevleetgstaYvlfYkr 337
           + v++   ++aYvlfYk+
   Q: 681  ACVQN---AEAYVLFYKK 695
           *****...********98 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MPPVSSCDCP HLDCVGEITK EELIQKSHGQ CQDCKVGGPN LWACLENGCA YVGCGESHTD 60
HSTVHSQDTR HNLTVNLTTL RVWCYACGKE VFLERKLGPH SPHGNSKPLP LPQNVGQDGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCCGG TGTCCAGCTG TGACTGCCCC CACCTGGACT GCGTGGGTGA GATCACCAAG 60
GAAGAACTTA TTCAAAAATC TCATGTGAGT GACCCTCTTC ACCTTCTGTT GTATTAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	70.13	0.00e+00	1299.00
IUUC-Apl-003987	Anas platyrhynchos	69.82	0.00e+00	1248.00
IUUC-Aca-004713	Anolis carolinensis	67.61	0.00e+00	1236.00
IUUC-Bta-013132	Bos taurus	70.82	0.00e+00	1315.00
IUUC-Cja-018811	Callithrix jacchus	70.76	0.00e+00	1305.00
IUUC-Cfa-021158	Canis familiaris	70.17	0.00e+00	1299.00
IUUC-Cpo-021910	Cavia porcellus	63.78	0.00e+00	1143.00
IUUC-Csa-023130	Chlorocebus sabaeus	70.93	0.00e+00	1305.00
IUUC-Cho-024383	Choloepus hoffmanni	50.43	2.00e-111	397.00
IUUC-Csv-025889	Ciona savignyi	43.87	2.00e-35	142.00
IUUC-Dre-028639	Danio rerio	81.60	0.00e+00	1475.00
IUUC-Dno-029416	Dasypus novemcinctus	70.50	0.00e+00	1271.00
IUUC-Ete-032994	Echinops telfairi	62.28	6.00e-132	465.00
IUUC-Eca-034248	Equus caballus	70.76	0.00e+00	1318.00
IUUC-Eeu-035357	Erinaceus europaeus	55.17	0.00e+00	892.00
IUUC-Fca-036013	Felis catus	68.69	0.00e+00	1251.00
IUUC-Fal-037509	Ficedula albicollis	68.90	0.00e+00	1264.00
IUUC-Gmo-038944	Gadus morhua	81.53	0.00e+00	1484.00
IUUC-Gga-040647	Gallus gallus	69.06	0.00e+00	1242.00
IUUC-Gac-041752	Gasterosteus aculeatus	91.12	0.00e+00	1692.00
IUUC-Hsa-045694	Homo sapiens	70.76	0.00e+00	1295.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	70.54	0.00e+00	1293.00
IUUC-Lch-050400	Latimeria chalumnae	68.64	0.00e+00	1237.00
IUUC-Loc-052616	Lepisosteus oculatus	77.63	0.00e+00	1436.00
IUUC-Laf-053493	Loxodonta africana	70.43	0.00e+00	1307.00
IUUC-Mcc-055542	Macaca mulatta	70.93	0.00e+00	1308.00
IUUC-Meu-056645	Macropus eugenii	62.20	0.00e+00	1078.00
IUUC-Mga-060019	Meleagris gallopavo	69.95	0.00e+00	1065.00
IUUC-Mmr-061241	Microcebus murinus	68.22	0.00e+00	1264.00
IUUC-Mmu-063786	Mus musculus	70.84	0.00e+00	1291.00
IUUC-Mpu-065772	Mustela putorius furo	70.13	0.00e+00	1100.00
IUUC-Mlu-067732	Myotis lucifugus	69.85	0.00e+00	1298.00
IUUC-Nle-069528	Nomascus leucogenys	70.11	0.00e+00	1302.00
IUUC-Opr-070606	Ochotona princeps	65.80	0.00e+00	1155.00
IUUC-Ocu-074457	Oryctolagus cuniculus	69.36	0.00e+00	1297.00
IUUC-Ola-086739	Oryzias latipes	89.05	0.00e+00	1707.00
IUUC-Oga-088720	Otolemur garnettii	70.39	0.00e+00	1311.00
IUUC-Oar-089921	Ovis aries	70.87	0.00e+00	1318.00
IUUC-Ptr-090526	Pan troglodytes	70.76	0.00e+00	1296.00
IUUC-Pan-092396	Papio anubis	70.78	0.00e+00	1305.00
IUUC-Psi-092971	Pelodiscus sinensis	70.76	0.00e+00	1305.00
IUUC-Pfo-097415	Poecilia formosa	88.22	0.00e+00	1634.00
IUUC-Pab-098740	Pongo abelii	70.76	0.00e+00	1317.00
IUUC-Pva-102820	Pteropus vampyrus	67.57	0.00e+00	1084.00
IUUC-Rno-104894	Rattus norvegicus	70.18	0.00e+00	1286.00
IUUC-Sha-107244	Sarcophilus harrisii	65.78	0.00e+00	1181.00
IUUC-Sar-113665	Sorex araneus	69.00	0.00e+00	1304.00
IUUC-Ssc-115793	Sus scrofa	69.92	0.00e+00	1269.00
IUUC-Tgu-117487	Taeniopygia guttata	70.63	0.00e+00	1241.00
IUUC-Tru-117694	Takifugu rubripes	85.36	0.00e+00	1633.00
IUUC-Tsy-119598	Tarsius syrichta	62.22	0.00e+00	1066.00
IUUC-Tni-120189	Tetraodon nigroviridis	82.96	0.00e+00	1544.00
IUUC-Tbe-128125	Tupaia belangeri	72.67	5.00e-77	282.00
IUUC-Ttr-128269	Tursiops truncatus	69.17	0.00e+00	1234.00
IUUC-Vpa-130598	Vicugna pacos	68.95	0.00e+00	1269.00
IUUC-Xtr-132044	Xenopus tropicalis	68.51	0.00e+00	1230.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence