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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063769
UUCD1 version UUC-MuM-00932
Ensembl Protein ID ENSMUSP00000001599.3
UniProt Accession Q9D5V2; Q8BVM3; Q9DA07; KLH10_MOUSE
Genbank Protein ID AAS91790.1; BAB24507.1; BAB29614.1; BAC36680.1
Protein Name Kelch-like protein 10
Genbank Nucleotide ID AY495337; AK006288; AK014906; AK077202
Gene Name Klhl10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000001558.5 ENSMUST00000001599.3 ENSMUSP00000001599.3
ENSMUSG00000001558.5 ENSMUST00000107395.2 ENSMUSP00000103018.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 5.10e-18 66.3 39 104
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.30e-11 43.5 138 169
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+++v+g ef+ahk +L+++Ss+F+alf++++++++ k+ ++i +++p+ ++ ++++ Yt ++++
   Q: 39   CDVVIKVNGFEFNAHKNILCSCSSYFRALFTSGWNNTE-KKVYNIPGISPDMMKLIIEYAYTRTVPI 104
           8**********************************998.***********************99986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+gi+ f d y cp+L+++a +fil++F+
   Q: 138  LDNCIGICKFTDYYYCPELRQKAYMFILHNFE 169
           69*****************************5 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility.
 May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility.
Protein Sequence
(Fasta)
MEMESTAAST RFHQPHMERK MSAMTCEIFN ELRLEGKLCD VVIKVNGFEF NAHKNILCSC 60
SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063769|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCCTATATG AAAGATGTAG TAGGGAAAAG GAGCGACAGC TGGCTAAAGG GGCCCCCCAT 60
AACCCTCCCC AACACCCCAG GAGAGCAGCC TCTCTCCCCT GGTCCCAAGG AGCCATGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063769|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0000902--P:cell morphogenesis
GO:0009566--P:fertilization
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0048808--P:male genitalia morphogenesis
GO:0008584--P:male gonad development
GO:0016567--P:protein ubiquitination
GO:0007286--P:spermatid development
KEGG mmu:66720
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001576 Ailuropoda melanoleuca 99.67 0.00e+00 1273.00
IUUC-Apl-003525 Anas platyrhynchos 82.49 0.00e+00 1052.00
IUUC-Aca-005295 Anolis carolinensis 88.12 0.00e+00 954.00
IUUC-Ang-009879 Aspergillus niger 26.92 1.00e-08 54.30
IUUC-Ame-010953 Astyanax mexicanus 48.25 1.00e-164 572.00
IUUC-Bta-013447 Bos taurus 99.67 0.00e+00 1272.00
IUUC-Cja-019472 Callithrix jacchus 98.95 0.00e+00 790.00
IUUC-Cfa-020332 Canis familiaris 99.84 0.00e+00 1274.00
IUUC-Cpo-021949 Cavia porcellus 98.03 0.00e+00 1253.00
IUUC-Csa-023573 Chlorocebus sabaeus 99.18 0.00e+00 1268.00
IUUC-Cho-024451 Choloepus hoffmanni 98.34 0.00e+00 1097.00
IUUC-Cin-025680 Ciona intestinalis 51.68 7.00e-173 600.00
IUUC-Csv-026085 Ciona savignyi 51.15 3.00e-172 598.00
IUUC-Dre-028799 Danio rerio 57.49 0.00e+00 690.00
IUUC-Dno-029608 Dasypus novemcinctus 100.00 0.00e+00 1278.00
IUUC-Dor-030200 Dipodomys ordii 100.00 0.00e+00 1140.00
IUUC-Dme-031964 Drosophila melanogaster 46.56 2.00e-153 536.00
IUUC-Ete-032475 Echinops telfairi 96.05 0.00e+00 1221.00
IUUC-Eca-034237 Equus caballus 99.84 0.00e+00 1274.00
IUUC-Eeu-035104 Erinaceus europaeus 88.99 8.00e-168 582.00
IUUC-Fca-036271 Felis catus 99.51 0.00e+00 1273.00
IUUC-Fal-037352 Ficedula albicollis 68.41 0.00e+00 852.00
IUUC-Ggr-040046 Gaeumannomyces graminis 29.73 4.00e-07 49.70
IUUC-Gga-040205 Gallus gallus 80.14 0.00e+00 1017.00
IUUC-Gac-041982 Gasterosteus aculeatus 54.20 0.00e+00 642.00
IUUC-Ggo-045241 Gorilla gorilla 98.85 0.00e+00 1264.00
IUUC-Hsa-047022 Homo sapiens 98.85 0.00e+00 1263.00
IUUC-Itr-048079 Ictidomys tridecemlineatus 100.00 0.00e+00 1276.00
IUUC-Lch-050637 Latimeria chalumnae 86.96 0.00e+00 1135.00
IUUC-Loc-052412 Lepisosteus oculatus 75.04 0.00e+00 962.00
IUUC-Laf-054118 Loxodonta africana 99.84 0.00e+00 1275.00
IUUC-Mcc-055476 Macaca mulatta 91.12 0.00e+00 1140.00
IUUC-Meu-056158 Macropus eugenii 100.00 0.00e+00 1276.00
IUUC-Mpo-057379 Magnaporthe poae 32.88 3.00e-07 48.90
IUUC-Mga-059634 Meleagris gallopavo 79.49 0.00e+00 1006.00
IUUC-Mmr-061217 Microcebus murinus 90.62 0.00e+00 1127.00
IUUC-Mdo-062138 Monodelphis domestica 100.00 0.00e+00 1275.00
IUUC-Mpu-066045 Mustela putorius furo 99.84 0.00e+00 1274.00
IUUC-Mlu-067348 Myotis lucifugus 99.34 0.00e+00 1269.00
IUUC-Nfi-068435 Neosartorya fischeri 30.65 8.00e-07 47.00
IUUC-Nle-069331 Nomascus leucogenys 98.52 0.00e+00 1258.00
IUUC-Opr-071203 Ochotona princeps 97.20 0.00e+00 1231.00
IUUC-Ont-071882 Oreochromis niloticus 49.66 3.00e-159 555.00
IUUC-Ocu-073757 Oryctolagus cuniculus 99.84 0.00e+00 1271.00
IUUC-Ola-086791 Oryzias latipes 49.08 5.00e-152 531.00
IUUC-Oga-088676 Otolemur garnettii 99.51 0.00e+00 1273.00
IUUC-Oar-089804 Ovis aries 99.51 0.00e+00 1269.00
IUUC-Ptr-090767 Pan troglodytes 98.52 0.00e+00 1259.00
IUUC-Pan-092856 Papio anubis 99.18 0.00e+00 1268.00
IUUC-Psi-094041 Pelodiscus sinensis 92.75 0.00e+00 1202.00
IUUC-Pfo-096673 Poecilia formosa 58.17 0.00e+00 664.00
IUUC-Pab-097694 Pongo abelii 98.52 0.00e+00 1259.00
IUUC-Pca-100693 Procavia capensis 92.27 0.00e+00 996.00
IUUC-Pva-102153 Pteropus vampyrus 100.00 0.00e+00 847.00
IUUC-Rno-105012 Rattus norvegicus 99.84 0.00e+00 1275.00
IUUC-Sha-106593 Sarcophilus harrisii 100.00 0.00e+00 1278.00
IUUC-Sar-113188 Sorex araneus 98.98 0.00e+00 1202.00
IUUC-Tgu-116852 Taeniopygia guttata 70.60 0.00e+00 843.00
IUUC-Tru-118098 Takifugu rubripes 48.82 4.00e-161 561.00
IUUC-Tsy-119581 Tarsius syrichta 85.86 0.00e+00 1063.00
IUUC-Tni-120002 Tetraodon nigroviridis 51.85 5.00e-163 567.00
IUUC-Tbe-127778 Tupaia belangeri 92.76 0.00e+00 1158.00
IUUC-Ttr-128966 Tursiops truncatus 93.09 0.00e+00 1165.00
IUUC-Vpa-130421 Vicugna pacos 99.74 0.00e+00 799.00
IUUC-Xtr-131853 Xenopus tropicalis 59.13 0.00e+00 685.00
IUUC-Xma-133112 Xiphophorus maculatus 58.53 0.00e+00 666.00
Created Date 25-Jun-2017

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