iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005364

Ensembl Protein ID

ENSACAP00000015233.2

UniProt Accession

H9GME8; H9GME8_ANOCA

Protein Name

Uncharacterized protein

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000015458.3	ENSACAT00000015541.3	ENSACAP00000015233.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.60e-21	75.5	872	923

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C++C+ ++ +e+ l++C++C++w+H+ C +l  eee+++  +  + C++C+
   Q: 872  TCPICQVKYVEEDLLIQCQHCERWMHAVCDNLFTEEEVEQAADegFDCTSCQ 923
           6*******************************9888888877778******7 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

DDLTLIGFAD GVSVREVFEL TGHFWAHHWC VVWSVGVLRP EGSWLSLVNK AVISGIAQKC 60
EHCNRWGATI PCHAEGCQRH YHFPCAAASG CFQSMKSLKL LCPEHLDQAV QMVPMCPSST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGACCTGA CCCTGATTGG CTTTGCAGAT GGGGTGTCAG TACGGGAAGT GTTTGAGCTA 60
ACAGGTGAGT ACTTGACACA GAAGAGCAGA ACCAGGCTTG GCAGGTTACT CCAGTGTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0008168--F:methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	92.57	0.00e+00	1114.00
IUUC-Ame-010612	Astyanax mexicanus	80.96	0.00e+00	1006.00
IUUC-Bta-013011	Bos taurus	52.28	0.00e+00	1315.00
IUUC-Cel-018354	Caenorhabditis elegans	36.75	2.00e-61	232.00
IUUC-Cja-019841	Callithrix jacchus	51.47	0.00e+00	1365.00
IUUC-Cfa-021131	Canis familiaris	53.12	0.00e+00	1181.00
IUUC-Cpo-021957	Cavia porcellus	53.08	0.00e+00	1310.00
IUUC-Csa-023722	Chlorocebus sabaeus	54.81	0.00e+00	1121.00
IUUC-Dno-029932	Dasypus novemcinctus	92.93	0.00e+00	1117.00
IUUC-Ete-032572	Echinops telfairi	94.19	0.00e+00	933.00
IUUC-Eeu-034848	Erinaceus europaeus	57.40	0.00e+00	830.00
IUUC-Fca-035424	Felis catus	53.36	0.00e+00	1152.00
IUUC-Fal-037179	Ficedula albicollis	96.34	0.00e+00	1125.00
IUUC-Gmo-038719	Gadus morhua	81.80	0.00e+00	897.00
IUUC-Gga-040815	Gallus gallus	57.55	0.00e+00	1586.00
IUUC-Gac-042436	Gasterosteus aculeatus	80.39	0.00e+00	991.00
IUUC-Ggo-044711	Gorilla gorilla	93.29	0.00e+00	1121.00
IUUC-Hsa-046567	Homo sapiens	93.29	0.00e+00	1121.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	52.87	0.00e+00	1342.00
IUUC-Loc-051979	Lepisosteus oculatus	82.74	0.00e+00	1060.00
IUUC-Laf-054377	Loxodonta africana	74.01	0.00e+00	1380.00
IUUC-Mcc-055577	Macaca mulatta	53.53	0.00e+00	1066.00
IUUC-Meu-055992	Macropus eugenii	93.98	0.00e+00	1068.00
IUUC-Mmr-061772	Microcebus murinus	53.24	0.00e+00	1352.00
IUUC-Mdo-062876	Monodelphis domestica	56.56	0.00e+00	684.00
IUUC-Mmu-063903	Mus musculus	54.60	0.00e+00	1123.00
IUUC-Mpu-066700	Mustela putorius furo	52.69	0.00e+00	1320.00
IUUC-Mlu-068180	Myotis lucifugus	50.81	0.00e+00	1375.00
IUUC-Nle-069362	Nomascus leucogenys	54.70	0.00e+00	1100.00
IUUC-Opr-070304	Ochotona princeps	80.70	0.00e+00	914.00
IUUC-Ont-071881	Oreochromis niloticus	56.89	0.00e+00	1215.00
IUUC-Ocu-074053	Oryctolagus cuniculus	53.19	0.00e+00	1154.00
IUUC-Ola-086384	Oryzias latipes	80.49	0.00e+00	1006.00
IUUC-Oga-088450	Otolemur garnettii	51.80	0.00e+00	1322.00
IUUC-Oar-089975	Ovis aries	91.42	0.00e+00	1126.00
IUUC-Ptr-091073	Pan troglodytes	54.97	0.00e+00	1102.00
IUUC-Pan-092871	Papio anubis	54.99	0.00e+00	1126.00
IUUC-Pfo-097525	Poecilia formosa	55.85	0.00e+00	1161.00
IUUC-Pab-097679	Pongo abelii	55.08	0.00e+00	1140.00
IUUC-Pca-100499	Procavia capensis	92.93	0.00e+00	1122.00
IUUC-Pva-102898	Pteropus vampyrus	49.96	0.00e+00	1327.00
IUUC-Rno-105660	Rattus norvegicus	50.83	0.00e+00	1642.00
IUUC-Sha-107431	Sarcophilus harrisii	93.61	0.00e+00	1083.00
IUUC-Sbi-113816	Sorghum bicolor	33.04	5.00e-13	70.10
IUUC-Ssc-115678	Sus scrofa	92.88	0.00e+00	1112.00
IUUC-Tru-117922	Takifugu rubripes	79.86	0.00e+00	995.00
IUUC-Tbe-127625	Tupaia belangeri	88.35	2.00e-132	469.00
IUUC-Ttr-129162	Tursiops truncatus	91.60	0.00e+00	1136.00
IUUC-Xtr-132455	Xenopus tropicalis	47.39	0.00e+00	1597.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence