iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000008240.1	ENSPSIT00000009130.1	ENSPSIP00000009084.1
ENSPSIG00000008240.1	ENSPSIT00000009147.1	ENSPSIP00000009101.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	9.10e-47	158.9	71	264

Active Site

Position(s)	Description	Evidence
78	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
81	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
258		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 71   YIRKTRPDGNCFYRAFGFShlealledskelqrfkeisakskedlvsqgfteftiedfhntxxxxxxxxxkqttvpeLLASFNDQSTSD 159
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqk...lvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpee 117
           +lv++Lr+lts ylq+es+ff++fie+++ +kefcq+   +vep++k +++ihi+aLaq+L+++i v+++d++e   gg ++p++fpe 
   Q: 160  YLVVYLRLLTSGYLQRESKFFEHFIEGGRSIKEFCQQpfqEVEPMCKeSDHIHIIALAQALNVSILVEYMDRGE---GGGTNPHVFPEG 245
           ***********************************9644488999****************************9...9*********** PP
   S: 118  klkkpivLlYrsgHYdaLva 137
           + +++++LlYr+gHYd+L++
   Q: 246  S-EPKVYLLYRPGHYDILYK 264
           *.****************96 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

AHSISSSLPG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSD RLELSVLYKE YAEDDHIYQQ 60
KIKDLLKKYS YIRKTRPDGN CFYRAFGFSH LEALLEDSKE LQRFKEISAK SKEDLVSQGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCATTCCA TCTCTTCTTC TCTTCCAGGA GTTAACTGTC TGGCATATGA TGAAGCCATC 60
ATGGCTCAGC AGGATCGCAT CCAGCAGGAG GTGAGCTTCC AGAGGGTTGT TGGGTGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	89.41	2.00e-133	468.00
IUUC-Apl-003233	Anas platyrhynchos	62.50	2.00e-16	76.30
IUUC-Aca-004648	Anolis carolinensis	87.40	2.00e-134	471.00
IUUC-Aly-005710	Arabidopsis lyrata	41.39	8.00e-46	176.00
IUUC-Ath-007112	Arabidopsis thaliana	41.24	9.00e-45	173.00
IUUC-Afl-008439	Aspergillus flavus	31.71	3.00e-06	45.10
IUUC-Ame-010662	Astyanax mexicanus	80.93	1.00e-120	425.00
IUUC-Bta-013533	Bos taurus	87.74	2.00e-133	467.00
IUUC-Bol-016100	Brassica oleracea	39.93	4.00e-44	171.00
IUUC-Bra-017705	Brassica rapa	38.13	6.00e-39	154.00
IUUC-Cel-018295	Caenorhabditis elegans	33.62	1.00e-34	139.00
IUUC-Cja-019190	Callithrix jacchus	87.74	6.00e-134	469.00
IUUC-Cfa-020430	Canis familiaris	89.49	8.00e-135	472.00
IUUC-Cpo-022355	Cavia porcellus	88.12	2.00e-134	471.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.00	1.00e-40	159.00
IUUC-Csa-023286	Chlorocebus sabaeus	84.81	1.00e-131	461.00
IUUC-Cho-024411	Choloepus hoffmanni	43.18	1.00e-25	108.00
IUUC-Cin-025507	Ciona intestinalis	44.21	1.00e-43	169.00
IUUC-Csv-026273	Ciona savignyi	49.19	4.00e-65	240.00
IUUC-Dre-028315	Danio rerio	79.13	7.00e-117	412.00
IUUC-Dno-029165	Dasypus novemcinctus	86.70	1.00e-102	365.00
IUUC-Dor-030943	Dipodomys ordii	88.12	2.00e-134	471.00
IUUC-Dme-031922	Drosophila melanogaster	53.36	3.00e-71	261.00
IUUC-Ete-032296	Echinops telfairi	83.95	3.00e-76	278.00
IUUC-Eca-033695	Equus caballus	88.33	3.00e-133	467.00
IUUC-Eeu-034775	Erinaceus europaeus	44.49	2.00e-53	201.00
IUUC-Fca-036441	Felis catus	87.69	2.00e-133	468.00
IUUC-Gmo-038908	Gadus morhua	78.60	3.00e-117	414.00
IUUC-Ggr-040020	Gaeumannomyces graminis	32.14	6.00e-30	125.00
IUUC-Gga-040460	Gallus gallus	82.75	4.00e-125	440.00
IUUC-Gac-042417	Gasterosteus aculeatus	76.68	4.00e-114	403.00
IUUC-Gma-043712	Glycine max	39.71	3.00e-45	174.00
IUUC-Ggo-044552	Gorilla gorilla	85.80	7.00e-79	286.00
IUUC-Hsa-046766	Homo sapiens	87.74	4.00e-134	470.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	88.12	2.00e-134	471.00
IUUC-Lch-050602	Latimeria chalumnae	76.47	1.00e-110	392.00
IUUC-Loc-052003	Lepisosteus oculatus	43.42	5.00e-49	187.00
IUUC-Laf-053705	Loxodonta africana	88.12	2.00e-134	471.00
IUUC-Mcc-055745	Macaca mulatta	82.08	1.00e-130	458.00
IUUC-Meu-056569	Macropus eugenii	77.78	2.00e-113	401.00
IUUC-Mtr-057712	Medicago truncatula	41.18	4.00e-43	167.00
IUUC-Mvi-060358	Microbotryum violaceum	32.73	1.00e-12	67.00
IUUC-Mmr-061123	Microcebus murinus	87.33	4.00e-110	390.00
IUUC-Mdo-062613	Monodelphis domestica	81.89	4.00e-104	370.00
IUUC-Mmu-063658	Mus musculus	88.12	2.00e-134	471.00
IUUC-Mac-065274	Musa acuminata	37.94	1.00e-38	153.00
IUUC-Mpu-066172	Mustela putorius furo	87.74	4.00e-134	470.00
IUUC-Mlu-066966	Myotis lucifugus	88.12	2.00e-134	471.00
IUUC-Nle-069519	Nomascus leucogenys	75.79	2.00e-79	288.00
IUUC-Opr-070761	Ochotona princeps	36.71	6.00e-26	109.00
IUUC-Ont-071901	Oreochromis niloticus	77.56	6.00e-116	409.00
IUUC-Oan-072922	Ornithorhynchus anatinus	44.93	8.00e-56	209.00
IUUC-Ocu-074643	Oryctolagus cuniculus	45.81	3.00e-55	207.00
IUUC-Oni-082026	Oryza nivara	26.74	1.00e-09	57.80
IUUC-Oru-084761	Oryza rufipogon	26.74	1.00e-09	57.80
IUUC-Ola-087331	Oryzias latipes	77.35	9.00e-80	289.00
IUUC-Oga-088064	Otolemur garnettii	87.74	4.00e-134	470.00
IUUC-Oar-089251	Ovis aries	89.37	1.00e-131	461.00
IUUC-Ptr-091430	Pan troglodytes	87.74	7.00e-134	469.00
IUUC-Pan-091969	Papio anubis	44.93	4.00e-54	203.00
IUUC-Pma-094366	Petromyzon marinus	70.52	4.00e-93	333.00
IUUC-Pfo-096734	Poecilia formosa	77.17	3.00e-107	380.00
IUUC-Pab-097919	Pongo abelii	86.88	2.00e-108	384.00
IUUC-Pop-099401	Populus trichocarpa	39.35	6.00e-43	167.00
IUUC-Pca-100252	Procavia capensis	41.05	9.00e-19	86.70
IUUC-Ppe-101977	Prunus persica	40.44	7.00e-46	177.00
IUUC-Pva-102499	Pteropus vampyrus	89.37	4.00e-133	466.00
IUUC-Pgr-103552	Puccinia graminis	30.67	2.20e-01	28.10
IUUC-Rno-105233	Rattus norvegicus	88.12	2.00e-134	471.00
IUUC-Sha-107081	Sarcophilus harrisii	90.20	1.00e-133	468.00
IUUC-Sly-111640	Solanum lycopersicum	41.18	9.00e-45	173.00
IUUC-Sar-113295	Sorex araneus	45.81	1.00e-53	202.00
IUUC-Ssc-116202	Sus scrofa	87.74	4.00e-134	470.00
IUUC-Tru-117664	Takifugu rubripes	74.81	2.00e-113	401.00
IUUC-Tni-120440	Tetraodon nigroviridis	34.78	2.00e-28	118.00
IUUC-Tca-121467	Theobroma cacao	40.36	4.00e-45	174.00
IUUC-Tbe-128116	Tupaia belangeri	84.76	6.00e-80	290.00
IUUC-Ttr-128622	Tursiops truncatus	86.97	1.00e-131	461.00
IUUC-Uma-129443	Ustilago maydis	29.91	3.00e-19	89.00
IUUC-Vvi-131389	Vitis vinifera	41.43	3.00e-48	184.00
IUUC-Xtr-131951	Xenopus tropicalis	39.91	7.00e-48	183.00
IUUC-Xma-134191	Xiphophorus maculatus	77.56	3.00e-108	384.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence