iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000003046.1	ENSLACT00000003443.1	ENSLACP00000003413.1
ENSLACG00000003046.1	ENSLACT00000003444.1	ENSLACP00000003414.1
ENSLACG00000003046.1	ENSLACT00000003445.1	ENSLACP00000003415.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-135	452.3	589	921

Active Site

Position(s)	Description	Evidence
890	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 676
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++LkpgG n  Vt+eNkeeY+ l++e
   Q: 677  GFSLPFYKRMLNKKLTIKDLESIDPEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKPGGTNLLVTEENKEEYIGLMAE 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++ q+++f +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i wFw++++e+++e r ++LqFv
   Q: 763  WRFCRGVQDQTKSFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLSDWQRNTVYRH-YTRNSKQIAWFWQFVKEMDNEVRLRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 921
           *********************************************************************96 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MATASSRSDT SNNHNGRSQL HVVVSCARLK RKKNWFGATI FVELSADGIT KKTAKSNGSN 60
PKWEEHLNVN VTQHTKLEFK VWSHHTLKAD ALLGKATVDL SQALEVHSRR LDNVKEVLKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGACGGCGT GGCCCCGGAG TGCGGCTGTC AGGCTGCGTG TGTGAGATGG CAGTCGGGAG 60
CGAGGAGCGC TGGGCAGGGA TGAGGCGCTG AGAGGAAACA GAAAACCAGG GAGTGTGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

lcm:102360416

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	77.16	0.00e+00	1407.00
IUUC-Apl-003310	Anas platyrhynchos	78.54	0.00e+00	1438.00
IUUC-Aca-005388	Anolis carolinensis	76.13	0.00e+00	1375.00
IUUC-Bta-012857	Bos taurus	77.26	0.00e+00	1400.00
IUUC-Cel-018299	Caenorhabditis elegans	67.88	0.00e+00	848.00
IUUC-Cja-019448	Callithrix jacchus	78.17	0.00e+00	1424.00
IUUC-Cfa-020728	Canis familiaris	77.80	0.00e+00	1425.00
IUUC-Cpo-021635	Cavia porcellus	76.00	0.00e+00	1402.00
IUUC-Csa-023805	Chlorocebus sabaeus	84.64	0.00e+00	1159.00
IUUC-Cin-025212	Ciona intestinalis	73.75	0.00e+00	912.00
IUUC-Csv-026256	Ciona savignyi	73.01	0.00e+00	907.00
IUUC-Dre-028245	Danio rerio	72.93	0.00e+00	1253.00
IUUC-Dno-029618	Dasypus novemcinctus	77.07	0.00e+00	1402.00
IUUC-Dme-032041	Drosophila melanogaster	71.12	0.00e+00	908.00
IUUC-Ete-032779	Echinops telfairi	91.20	0.00e+00	1075.00
IUUC-Eca-033313	Equus caballus	77.49	0.00e+00	1395.00
IUUC-Eeu-035259	Erinaceus europaeus	70.44	0.00e+00	1236.00
IUUC-Fca-035420	Felis catus	77.55	0.00e+00	1420.00
IUUC-Fal-037335	Ficedula albicollis	79.20	0.00e+00	1436.00
IUUC-Gmo-039172	Gadus morhua	87.65	0.00e+00	1066.00
IUUC-Gga-040246	Gallus gallus	77.93	0.00e+00	1432.00
IUUC-Gac-042211	Gasterosteus aculeatus	93.33	0.00e+00	1189.00
IUUC-Ggo-045001	Gorilla gorilla	78.74	0.00e+00	1267.00
IUUC-Hsa-046544	Homo sapiens	77.93	0.00e+00	1419.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	77.63	0.00e+00	1379.00
IUUC-Loc-052116	Lepisosteus oculatus	93.52	0.00e+00	1203.00
IUUC-Laf-053551	Loxodonta africana	78.26	0.00e+00	1410.00
IUUC-Mga-059986	Meleagris gallopavo	78.97	0.00e+00	1432.00
IUUC-Mmr-060945	Microcebus murinus	75.59	0.00e+00	1351.00
IUUC-Mmu-063202	Mus musculus	77.32	0.00e+00	1381.00
IUUC-Mpu-065773	Mustela putorius furo	77.79	0.00e+00	1417.00
IUUC-Nle-069188	Nomascus leucogenys	78.47	0.00e+00	1427.00
IUUC-Opr-070965	Ochotona princeps	75.38	0.00e+00	1355.00
IUUC-Ont-072226	Oreochromis niloticus	92.49	0.00e+00	1201.00
IUUC-Oan-073497	Ornithorhynchus anatinus	79.23	0.00e+00	1415.00
IUUC-Ocu-073891	Oryctolagus cuniculus	74.22	0.00e+00	1310.00
IUUC-Ola-087438	Oryzias latipes	91.49	0.00e+00	1188.00
IUUC-Oga-087922	Otolemur garnettii	77.77	0.00e+00	1407.00
IUUC-Oar-089429	Ovis aries	77.77	0.00e+00	1332.00
IUUC-Ptr-090484	Pan troglodytes	77.93	0.00e+00	1419.00
IUUC-Pan-092117	Papio anubis	77.93	0.00e+00	1420.00
IUUC-Psi-093338	Pelodiscus sinensis	78.58	0.00e+00	1467.00
IUUC-Pma-094279	Petromyzon marinus	73.87	0.00e+00	846.00
IUUC-Pfo-096171	Poecilia formosa	92.49	0.00e+00	1201.00
IUUC-Pab-098654	Pongo abelii	82.32	0.00e+00	1121.00
IUUC-Pva-102811	Pteropus vampyrus	71.92	0.00e+00	1242.00
IUUC-Rno-106125	Rattus norvegicus	76.81	0.00e+00	1388.00
IUUC-Sha-107243	Sarcophilus harrisii	78.63	0.00e+00	1427.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	49.21	5.00e-158	551.00
IUUC-Sre-114929	Sporisorium reilianum	45.76	6.00e-152	531.00
IUUC-Ssc-115368	Sus scrofa	76.91	0.00e+00	1395.00
IUUC-Tgu-117079	Taeniopygia guttata	78.75	0.00e+00	1421.00
IUUC-Tru-118062	Takifugu rubripes	93.16	0.00e+00	1207.00
IUUC-Tsy-119507	Tarsius syrichta	72.80	0.00e+00	1297.00
IUUC-Tni-120151	Tetraodon nigroviridis	92.81	0.00e+00	1189.00
IUUC-Ttr-129260	Tursiops truncatus	66.92	0.00e+00	1151.00
IUUC-Xtr-132877	Xenopus tropicalis	67.86	0.00e+00	1195.00
IUUC-Xma-133778	Xiphophorus maculatus	92.32	0.00e+00	1199.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence