iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087438

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

BAAF04086680

Gene Name

wwp1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000005146.1	ENSORLT00000006491.1	ENSORLP00000006490.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-134	448.5	592	924

Active Site

Position(s)	Description	Evidence
893	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 592  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASAI-NPDHLSYFCFIGRFIAMALFHGKFIDT 679
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lkp+G+ni+Vt+eNkeeY+++++e
   Q: 680  GFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDN---NIEECGLEMFFSVDMEILGKITSHDLKPDGANIQVTEENKEEYISQMAE 765
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 766  WRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 853
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 854  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 924
           *********************************************************************96 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MATASSRAET SHNHRQTSQL HAIVSCAKLK RKKSLFGTTI YVEVTADGES HRTTKSHSSS 60
NPKWDETLIL NVTPHTQVEF KVWSHHTLKA DALLGKAKLD LIQALEQHDR KLENVKEVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGAGCCGT AGTAGACTGC GAGGCCTGTA CGGTTCCCGA CAACCGCTAC GTGACGAGCA 60
GGGATTGTAA ATGGAGGAGC GAACAAGGTA AAAACAACAC CGCCCGTGTT CTTTCTTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	72.13	0.00e+00	1312.00
IUUC-Apl-003310	Anas platyrhynchos	89.98	0.00e+00	1154.00
IUUC-Aca-005388	Anolis carolinensis	69.69	0.00e+00	1294.00
IUUC-Bta-012857	Bos taurus	73.31	0.00e+00	1315.00
IUUC-Cel-018299	Caenorhabditis elegans	67.07	0.00e+00	835.00
IUUC-Cja-019448	Callithrix jacchus	72.45	0.00e+00	1327.00
IUUC-Cfa-020728	Canis familiaris	72.23	0.00e+00	1324.00
IUUC-Cpo-021635	Cavia porcellus	69.72	0.00e+00	1303.00
IUUC-Csa-023805	Chlorocebus sabaeus	89.14	0.00e+00	1125.00
IUUC-Cin-025212	Ciona intestinalis	73.58	0.00e+00	912.00
IUUC-Csv-026256	Ciona savignyi	72.84	0.00e+00	907.00
IUUC-Dre-028245	Danio rerio	75.03	0.00e+00	1264.00
IUUC-Dno-029618	Dasypus novemcinctus	69.87	0.00e+00	1313.00
IUUC-Dme-032041	Drosophila melanogaster	70.88	0.00e+00	896.00
IUUC-Ete-032779	Echinops telfairi	89.08	0.00e+00	1055.00
IUUC-Eca-033313	Equus caballus	91.19	0.00e+00	1125.00
IUUC-Eeu-035259	Erinaceus europaeus	65.47	0.00e+00	1149.00
IUUC-Fca-035420	Felis catus	72.16	0.00e+00	1318.00
IUUC-Fal-037335	Ficedula albicollis	73.17	0.00e+00	1362.00
IUUC-Gmo-039172	Gadus morhua	89.77	0.00e+00	1086.00
IUUC-Gga-040246	Gallus gallus	73.75	0.00e+00	1354.00
IUUC-Gac-042211	Gasterosteus aculeatus	96.58	0.00e+00	1221.00
IUUC-Ggo-045001	Gorilla gorilla	72.16	0.00e+00	1181.00
IUUC-Hsa-046544	Homo sapiens	71.52	0.00e+00	1324.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	72.23	0.00e+00	1301.00
IUUC-Lch-050398	Latimeria chalumnae	91.49	0.00e+00	1157.00
IUUC-Loc-052116	Lepisosteus oculatus	95.09	0.00e+00	1202.00
IUUC-Laf-053551	Loxodonta africana	70.37	0.00e+00	1311.00
IUUC-Mga-059986	Meleagris gallopavo	72.95	0.00e+00	1353.00
IUUC-Mmr-060945	Microcebus murinus	69.51	0.00e+00	1260.00
IUUC-Mdo-063024	Monodelphis domestica	92.99	0.00e+00	1077.00
IUUC-Mmu-063202	Mus musculus	91.65	0.00e+00	1135.00
IUUC-Mpu-065773	Mustela putorius furo	72.40	0.00e+00	1315.00
IUUC-Nle-069188	Nomascus leucogenys	72.45	0.00e+00	1330.00
IUUC-Opr-070965	Ochotona princeps	70.76	0.00e+00	1279.00
IUUC-Ont-072226	Oreochromis niloticus	97.64	0.00e+00	1249.00
IUUC-Oan-073497	Ornithorhynchus anatinus	92.59	0.00e+00	1150.00
IUUC-Ocu-073891	Oryctolagus cuniculus	68.54	0.00e+00	1224.00
IUUC-Oga-087922	Otolemur garnettii	72.82	0.00e+00	1324.00
IUUC-Oar-089429	Ovis aries	72.58	0.00e+00	1258.00
IUUC-Ptr-090484	Pan troglodytes	71.41	0.00e+00	1323.00
IUUC-Pan-092117	Papio anubis	72.13	0.00e+00	1324.00
IUUC-Psi-093338	Pelodiscus sinensis	73.32	0.00e+00	1359.00
IUUC-Pma-094279	Petromyzon marinus	72.82	0.00e+00	834.00
IUUC-Pfo-096171	Poecilia formosa	97.79	0.00e+00	1240.00
IUUC-Pab-098654	Pongo abelii	86.80	0.00e+00	1088.00
IUUC-Pva-102811	Pteropus vampyrus	91.67	0.00e+00	1128.00
IUUC-Rno-106125	Rattus norvegicus	71.70	0.00e+00	1330.00
IUUC-Sha-107243	Sarcophilus harrisii	70.89	0.00e+00	1320.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	49.21	1.00e-157	550.00
IUUC-Ssc-115368	Sus scrofa	91.39	0.00e+00	1134.00
IUUC-Tgu-117079	Taeniopygia guttata	73.11	0.00e+00	1355.00
IUUC-Tru-118062	Takifugu rubripes	96.60	0.00e+00	1228.00
IUUC-Tsy-119507	Tarsius syrichta	67.55	0.00e+00	1210.00
IUUC-Tni-120151	Tetraodon nigroviridis	96.43	0.00e+00	1212.00
IUUC-Xtr-132877	Xenopus tropicalis	64.43	0.00e+00	1122.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence