iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062480

UUCD1 version

UUC-MoD-00292

Ensembl Protein ID

ENSMODP00000017047.3

UniProt Accession

F6UWQ9; F6UWQ9_MONDO

Protein Name

Nitric oxide synthase-interacting protein

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013629.3	ENSMODT00000017363.3	ENSMODP00000017047.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.70e-14	52.7	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G  y+r++I +++ ++++
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGFLYEREAILEYILHQKR 79
           567789*****************************98877 PP

Organism

Monodelphis domestica

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNVRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGFLYEREAI LEYILHQKRE IARQRKAYEK QRGAQKEERR ELSRAAAQDQ LRGFLEKEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGGGGG GCGTTTCCCA ACACTAATGG TTCCCGGGCC AGGGGAGGAA ATTGAGGCCG 60
GATTGGCCCC GGGCCCCTAG CTCAGCACCC GCTGCTCCCC CAGAGCTACA TGGGTCCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination

KEGG

mdo:100021844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	45.35	3.00e-16	80.10
IUUC-Aml-002069	Ailuropoda melanoleuca	80.70	3.00e-146	510.00
IUUC-Atr-002661	Amborella trichopoda	33.56	6.00e-31	127.00
IUUC-Aca-004630	Anolis carolinensis	74.09	4.00e-132	463.00
IUUC-Aly-006316	Arabidopsis lyrata	30.26	6.00e-30	124.00
IUUC-Ath-007000	Arabidopsis thaliana	28.85	1.00e-29	123.00
IUUC-Acl-008175	Aspergillus clavatus	32.76	1.00e-06	47.40
IUUC-Afl-008440	Aspergillus flavus	32.48	6.00e-06	45.10
IUUC-Afu-009012	Aspergillus fumigatus	33.33	8.00e-07	48.10
IUUC-Ang-009556	Aspergillus niger	34.19	5.00e-06	45.40
IUUC-Aor-009892	Aspergillus oryzae	32.48	6.00e-06	45.10
IUUC-Ame-011874	Astyanax mexicanus	64.94	6.00e-108	383.00
IUUC-Bgr-012090	Blumeria graminis	26.50	1.00e-07	50.40
IUUC-Bta-012956	Bos taurus	84.54	2.00e-152	531.00
IUUC-Bci-013897	Botrytis cinerea	41.25	2.00e-09	56.60
IUUC-Bdi-014968	Brachypodium distachyon	31.19	1.00e-35	143.00
IUUC-Bol-015578	Brassica oleracea	29.14	6.00e-35	140.00
IUUC-Bra-017234	Brassica rapa	29.14	6.00e-35	140.00
IUUC-Cel-018637	Caenorhabditis elegans	43.30	6.00e-59	220.00
IUUC-Cja-019632	Callithrix jacchus	83.50	7.00e-151	526.00
IUUC-Cfa-020192	Canis familiaris	83.17	4.00e-149	520.00
IUUC-Cpo-021939	Cavia porcellus	82.39	6.00e-145	506.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	35.10	3.00e-42	165.00
IUUC-Csa-023802	Chlorocebus sabaeus	83.50	1.00e-150	525.00
IUUC-Cho-024637	Choloepus hoffmanni	68.66	8.00e-73	266.00
IUUC-Cin-025180	Ciona intestinalis	49.67	5.00e-84	303.00
IUUC-Csv-026206	Ciona savignyi	47.87	6.00e-44	169.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	23.47	7.00e-14	71.60
IUUC-Cne-026827	Cryptococcus neoformans	36.36	3.00e-06	46.20
IUUC-Dre-028092	Danio rerio	66.23	2.00e-115	408.00
IUUC-Dno-029501	Dasypus novemcinctus	79.93	6.00e-129	453.00
IUUC-Dor-030542	Dipodomys ordii	83.17	3.00e-150	523.00
IUUC-Dse-031188	Dothistroma septosporum	23.81	4.00e-12	65.50
IUUC-Dme-031734	Drosophila melanogaster	47.73	1.00e-78	286.00
IUUC-Eca-033577	Equus caballus	85.15	2.00e-153	535.00
IUUC-Fca-035761	Felis catus	84.16	5.00e-151	526.00
IUUC-Fox-037703	Fusarium oxysporum	28.40	4.00e-10	58.90
IUUC-Fso-038208	Fusarium solani	28.42	8.00e-12	64.30
IUUC-Gmo-038523	Gadus morhua	56.35	2.00e-58	218.00
IUUC-Ggr-040087	Gaeumannomyces graminis	39.74	1.00e-09	57.00
IUUC-Gac-042621	Gasterosteus aculeatus	60.69	5.00e-106	377.00
IUUC-Gma-042698	Glycine max	30.58	7.00e-32	130.00
IUUC-Ggo-045357	Gorilla gorilla	83.83	3.00e-151	527.00
IUUC-Hsa-046195	Homo sapiens	83.83	3.00e-151	527.00
IUUC-Hvu-047174	Hordeum vulgare	31.53	1.00e-36	146.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	82.72	7.00e-146	509.00
IUUC-Lch-050569	Latimeria chalumnae	65.58	3.00e-111	394.00
IUUC-Lpe-050992	Leersia perrieri	35.15	3.00e-22	99.80
IUUC-Loc-052522	Lepisosteus oculatus	68.33	3.00e-114	404.00
IUUC-Lma-053254	Leptosphaeria maculans	23.65	1.00e-11	64.30
IUUC-Laf-053397	Loxodonta africana	84.49	6.00e-153	533.00
IUUC-Mcc-054681	Macaca mulatta	83.83	4.00e-151	527.00
IUUC-Meu-056723	Macropus eugenii	95.68	1.00e-168	584.00
IUUC-Mor-056961	Magnaporthe oryzae	39.29	6.00e-10	58.50
IUUC-Mpo-057359	Magnaporthe poae	27.89	2.00e-06	46.20
IUUC-Mtr-058063	Medicago truncatula	31.85	4.00e-33	134.00
IUUC-Mla-059004	Melampsora laricipopulina	30.28	1.00e-27	116.00
IUUC-Mvi-060460	Microbotryum violaceum	31.04	4.00e-26	112.00
IUUC-Mmr-060847	Microcebus murinus	84.16	3.00e-151	527.00
IUUC-Mmu-063809	Mus musculus	84.54	4.00e-150	523.00
IUUC-Mac-064870	Musa acuminata	30.58	1.00e-32	133.00
IUUC-Mpu-066322	Mustela putorius furo	85.15	4.00e-154	537.00
IUUC-Mlu-067556	Myotis lucifugus	81.25	8.00e-145	506.00
IUUC-Nfi-068440	Neosartorya fischeri	33.33	9.00e-07	48.10
IUUC-Ncr-068898	Neurospora crassa	37.18	2.00e-07	50.10
IUUC-Nle-070049	Nomascus leucogenys	83.83	4.00e-151	527.00
IUUC-Opr-070972	Ochotona princeps	82.57	1.00e-142	499.00
IUUC-Ont-071682	Oreochromis niloticus	64.80	5.00e-116	410.00
IUUC-Oan-073296	Ornithorhynchus anatinus	100.00	1.00e-32	132.00
IUUC-Ocu-074218	Oryctolagus cuniculus	82.62	1.00e-119	422.00
IUUC-Oba-075284	Oryza barthii	32.19	9.00e-37	147.00
IUUC-Obr-076651	Oryza brachyantha	31.51	2.00e-36	145.00
IUUC-Ogl-077899	Oryza glaberrima	32.19	9.00e-37	147.00
IUUC-Ogu-078477	Oryza glumaepatula	32.53	4.00e-37	148.00
IUUC-Oin-080011	Oryza indica	32.19	9.00e-37	147.00
IUUC-Olo-080545	Oryza longistaminata	31.58	5.00e-28	119.00
IUUC-Ome-081543	Oryza meridionalis	32.19	9.00e-37	147.00
IUUC-Oni-082955	Oryza nivara	32.19	9.00e-37	147.00
IUUC-Opu-083565	Oryza punctata	31.85	1.00e-35	143.00
IUUC-Oru-084474	Oryza rufipogon	32.19	9.00e-37	147.00
IUUC-Osa-085913	Oryza sativa	32.19	9.00e-37	147.00
IUUC-Ola-086851	Oryzias latipes	67.11	6.00e-120	423.00
IUUC-Olu-087724	Ostreococcus lucimarinus	38.83	4.00e-14	72.00
IUUC-Oga-087970	Otolemur garnettii	83.55	1.00e-149	521.00
IUUC-Oar-089756	Ovis aries	81.31	2.00e-141	494.00
IUUC-Ptr-091485	Pan troglodytes	82.84	1.00e-147	515.00
IUUC-Pan-091832	Papio anubis	83.83	2.00e-151	527.00
IUUC-Pma-094551	Petromyzon marinus	63.52	5.00e-108	383.00
IUUC-Pno-094830	Phaeosphaeria nodorum	26.61	6.00e-08	51.60
IUUC-Ppa-095255	Physcomitrella patens	32.11	4.00e-32	131.00
IUUC-Pfo-096373	Poecilia formosa	64.61	6.00e-116	410.00
IUUC-Pab-098247	Pongo abelii	83.83	5.00e-151	526.00
IUUC-Pop-099186	Populus trichocarpa	29.90	2.00e-30	125.00
IUUC-Pca-100677	Procavia capensis	80.14	8.00e-121	426.00
IUUC-Ppe-101403	Prunus persica	29.11	2.00e-31	129.00
IUUC-Pva-103000	Pteropus vampyrus	84.49	4.00e-152	530.00
IUUC-Pgr-103663	Puccinia graminis	30.03	3.00e-30	125.00
IUUC-Ptt-103712	Puccinia triticina	40.00	4.00e-09	55.10
IUUC-Pte-104287	Pyrenophora teres	26.06	1.00e-15	77.00
IUUC-Pyt-104579	Pyrenophora triticirepentis	25.62	1.00e-11	63.90
IUUC-Rno-106069	Rattus norvegicus	84.21	7.00e-150	522.00
IUUC-Sha-106553	Sarcophilus harrisii	93.36	3.00e-165	573.00
IUUC-Smo-108874	Selaginella moellendorffii	32.44	2.00e-39	156.00
IUUC-Sit-110307	Setaria italica	32.20	8.00e-36	144.00
IUUC-Sly-111094	Solanum lycopersicum	32.08	1.00e-32	133.00
IUUC-Stu-112363	Solanum tuberosum	32.19	2.00e-32	132.00
IUUC-Sar-113480	Sorex araneus	82.39	5.00e-142	496.00
IUUC-Sbi-113939	Sorghum bicolor	32.53	1.00e-36	146.00
IUUC-Ssc-115644	Sus scrofa	85.48	5.00e-154	536.00
IUUC-Tru-118781	Takifugu rubripes	63.19	2.00e-114	405.00
IUUC-Tni-119672	Tetraodon nigroviridis	72.41	3.00e-34	135.00
IUUC-Tca-121795	Theobroma cacao	31.27	4.00e-35	141.00
IUUC-Tre-122037	Trichoderma reesei	35.06	6.00e-08	52.00
IUUC-Tvi-122524	Trichoderma virens	26.64	2.00e-18	86.30
IUUC-Tae-122828	Triticum aestivum	31.86	8.00e-37	147.00
IUUC-Tur-126387	Triticum urartu	29.97	2.00e-28	120.00
IUUC-Tme-127111	Tuber melanosporum	37.80	3.00e-09	55.80
IUUC-Ttr-128227	Tursiops truncatus	84.49	5.00e-151	526.00
IUUC-Vda-129924	Verticillium dahliae	24.79	4.00e-13	68.90
IUUC-Vpa-130802	Vicugna pacos	83.15	8.00e-39	153.00
IUUC-Vvi-131105	Vitis vinifera	31.62	1.00e-34	139.00
IUUC-Xtr-132830	Xenopus tropicalis	64.81	3.00e-119	421.00
IUUC-Xma-133618	Xiphophorus maculatus	62.75	2.00e-109	388.00
IUUC-Zma-135389	Zea mays	31.51	8.00e-34	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence