iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063335

UUCD1 version

UUC-MuM-00168

Ensembl Protein ID

ENSMUSP00000099809.4

UniProt Accession

Q9WV66; MARH7_MOUSE

Genbank Protein ID

AAD38411.1; BAE38928.1; BAE39367.1; BAE40429.1; AAH25029.1

Protein Name

E3 ubiquitin-protein ligase MARCH7; Axotrophin; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; RING-type E3 ubiquitin transferase MARCH7

Genbank Nucleotide ID

AF155739; AK166666; AK167246; AK168555; BC025029

Gene Name

March7; Axot

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026977.17	ENSMUST00000102748.10	ENSMUSP00000099809.4
ENSMUSG00000026977.17	ENSMUST00000142485.1	ENSMUSP00000116925.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	83.72	0.00e+00	894.00	IUUC-Hsa-046883

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion.

Protein Sequence
(Fasta)

MESKPSRIPR RISVQPSGSL STRMVSGNRG TSLNDSYHSR DSSFRLDSEY QSASASACAS 60
PCQPAWYSES EIPQGARARA QTQQRDHDSK RPKLSCTNCA STSAGRNGGS GLNTVSDSSW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGAGGAG GAAGGGCGGG GCTGCCAACG GCGGCGGCCA CTTCTGCGGC GCATCCGGAG 60
GGGCGGCCGC CATTGTGCTT CGTCGCCGAC TTCTCTGCCG GTAGCCCGAG AGCCGAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0042130--P:negative regulation of T cell proliferation
GO:0016567--P:protein ubiquitination
GO:0002643--P:regulation of tolerance induction

KEGG

mmu:57438

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002345	Ailuropoda melanoleuca	45.93	9.00e-31	129.00
IUUC-Apl-003999	Anas platyrhynchos	62.10	2.00e-171	595.00
IUUC-Aca-005296	Anolis carolinensis	60.35	2.00e-148	520.00
IUUC-Ame-011193	Astyanax mexicanus	49.58	9.00e-65	241.00
IUUC-Bta-013333	Bos taurus	80.49	0.00e+00	907.00
IUUC-Bra-017315	Brassica rapa	28.85	9.00e-08	51.60
IUUC-Cja-019610	Callithrix jacchus	83.38	0.00e+00	832.00
IUUC-Cfa-021250	Canis familiaris	82.82	0.00e+00	865.00
IUUC-Cpo-022016	Cavia porcellus	82.03	0.00e+00	759.00
IUUC-Csa-023420	Chlorocebus sabaeus	84.52	0.00e+00	842.00
IUUC-Cho-024306	Choloepus hoffmanni	57.89	1.00e-26	115.00
IUUC-Dre-027865	Danio rerio	58.72	1.00e-58	221.00
IUUC-Dno-030094	Dasypus novemcinctus	83.26	0.00e+00	907.00
IUUC-Dor-030822	Dipodomys ordii	76.24	0.00e+00	857.00
IUUC-Ete-032649	Echinops telfairi	83.38	0.00e+00	912.00
IUUC-Eca-033241	Equus caballus	82.48	0.00e+00	858.00
IUUC-Eeu-035188	Erinaceus europaeus	77.69	5.00e-170	591.00
IUUC-Fca-035415	Felis catus	82.65	0.00e+00	866.00
IUUC-Fal-036666	Ficedula albicollis	55.29	3.00e-164	572.00
IUUC-Gac-041953	Gasterosteus aculeatus	40.38	6.00e-48	185.00
IUUC-Gma-043479	Glycine max	25.86	6.00e-07	48.90
IUUC-Ggo-045544	Gorilla gorilla	83.67	0.00e+00	803.00
IUUC-Hsa-046883	Homo sapiens	83.97	0.00e+00	809.00
IUUC-Itr-047989	Ictidomys tridecemlineatus	82.80	0.00e+00	695.00
IUUC-Lch-050154	Latimeria chalumnae	58.50	1.00e-35	144.00
IUUC-Loc-051840	Lepisosteus oculatus	69.59	2.00e-76	280.00
IUUC-Laf-054541	Loxodonta africana	82.17	0.00e+00	846.00
IUUC-Mcc-054882	Macaca mulatta	84.55	0.00e+00	801.00
IUUC-Meu-056145	Macropus eugenii	42.50	2.00e-08	55.10
IUUC-Mtr-058438	Medicago truncatula	29.17	3.00e-08	53.10
IUUC-Mga-059356	Meleagris gallopavo	60.03	2.00e-161	563.00
IUUC-Mmr-060788	Microcebus murinus	84.99	0.00e+00	869.00
IUUC-Mdo-062794	Monodelphis domestica	74.76	0.00e+00	740.00
IUUC-Mpu-066830	Mustela putorius furo	82.22	0.00e+00	869.00
IUUC-Mlu-067138	Myotis lucifugus	82.04	0.00e+00	889.00
IUUC-Nle-069584	Nomascus leucogenys	83.53	0.00e+00	803.00
IUUC-Opr-070434	Ochotona princeps	78.23	1.00e-106	380.00
IUUC-Ont-072653	Oreochromis niloticus	55.44	2.00e-50	193.00
IUUC-Ocu-074137	Oryctolagus cuniculus	83.70	0.00e+00	865.00
IUUC-Oga-088502	Otolemur garnettii	83.24	0.00e+00	838.00
IUUC-Oar-090338	Ovis aries	79.59	0.00e+00	895.00
IUUC-Ptr-090675	Pan troglodytes	83.97	0.00e+00	809.00
IUUC-Pan-092888	Papio anubis	84.26	0.00e+00	799.00
IUUC-Psi-094028	Pelodiscus sinensis	64.77	0.00e+00	630.00
IUUC-Pfo-096417	Poecilia formosa	61.71	5.00e-51	196.00
IUUC-Pab-097652	Pongo abelii	83.97	0.00e+00	806.00
IUUC-Pop-099336	Populus trichocarpa	40.62	7.00e-08	52.00
IUUC-Pca-100973	Procavia capensis	74.53	9.00e-122	431.00
IUUC-Ppe-101419	Prunus persica	30.17	4.00e-07	49.70
IUUC-Pva-103013	Pteropus vampyrus	81.51	0.00e+00	835.00
IUUC-Rno-105410	Rattus norvegicus	91.64	0.00e+00	1040.00
IUUC-Sha-107373	Sarcophilus harrisii	73.00	0.00e+00	746.00
IUUC-Sar-113462	Sorex araneus	77.34	0.00e+00	813.00
IUUC-Ssc-115620	Sus scrofa	55.14	2.00e-28	120.00
IUUC-Tgu-116487	Taeniopygia guttata	61.42	6.00e-171	594.00
IUUC-Tru-118111	Takifugu rubripes	60.56	3.00e-49	189.00
IUUC-Tni-120549	Tetraodon nigroviridis	60.58	6.00e-47	181.00
IUUC-Tae-124283	Triticum aestivum	37.70	2.00e-07	48.90
IUUC-Tbe-127282	Tupaia belangeri	76.22	0.00e+00	746.00
IUUC-Ttr-129177	Tursiops truncatus	79.48	0.00e+00	817.00
IUUC-Vpa-130101	Vicugna pacos	80.15	0.00e+00	744.00
IUUC-Vvi-131606	Vitis vinifera	36.07	1.00e-07	51.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence