iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000066877.11	ENSMUST00000086421.8	ENSMUSP00000083611.5
ENSMUSG00000066877.11	ENSMUST00000114744.2	ENSMUSP00000110392.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-44	151.2	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELSFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Mus musculus

Functional Description
(View)

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling (By similarity).

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIRKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT RRKPSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGTAACAA AGATGAGGTC TGTAACAAAG AACGGATGAA GCTAGCATCT CCGACTGGAA 60
GAGACTGTTG GGTGTGCTGA TTTTGTACAG GATGCCTCCT AGTGCCCTCG TGTCAGGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0810--Translation regulation

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0014069--C:postsynaptic density
GO:0045202--C:synapse
GO:0012506--C:vesicle membrane
GO:0032403--F:protein complex binding
GO:0097110--F:scaffold protein binding
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0060996--P:dendritic spine development
GO:0048013--P:ephrin receptor signaling pathway
GO:0001771--P:immunological synapse formation
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

mmu:17974

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	94.74	0.00e+00	719.00
IUUC-Apl-003456	Anas platyrhynchos	89.47	0.00e+00	695.00
IUUC-Aca-005105	Anolis carolinensis	88.68	0.00e+00	691.00
IUUC-Ame-010966	Astyanax mexicanus	78.07	2.00e-173	601.00
IUUC-Bta-012424	Bos taurus	87.37	4.00e-180	624.00
IUUC-Cel-018144	Caenorhabditis elegans	41.77	6.00e-75	274.00
IUUC-Cja-019898	Callithrix jacchus	95.79	0.00e+00	724.00
IUUC-Cfa-020830	Canis familiaris	94.74	0.00e+00	717.00
IUUC-Cpo-021487	Cavia porcellus	88.68	0.00e+00	647.00
IUUC-Csa-023693	Chlorocebus sabaeus	95.79	0.00e+00	724.00
IUUC-Cin-025348	Ciona intestinalis	37.76	9.00e-68	250.00
IUUC-Dre-028334	Danio rerio	80.68	3.00e-175	607.00
IUUC-Dno-028973	Dasypus novemcinctus	92.63	0.00e+00	707.00
IUUC-Dor-031003	Dipodomys ordii	96.32	0.00e+00	707.00
IUUC-Ete-032792	Echinops telfairi	84.11	0.00e+00	635.00
IUUC-Eca-033656	Equus caballus	95.26	0.00e+00	721.00
IUUC-Fca-036347	Felis catus	94.74	0.00e+00	718.00
IUUC-Fal-037095	Ficedula albicollis	89.21	0.00e+00	696.00
IUUC-Gmo-039410	Gadus morhua	70.66	4.00e-158	550.00
IUUC-Gga-040155	Gallus gallus	89.47	0.00e+00	695.00
IUUC-Gac-041787	Gasterosteus aculeatus	72.59	6.00e-164	570.00
IUUC-Ggo-044805	Gorilla gorilla	96.05	0.00e+00	726.00
IUUC-Hsa-046585	Homo sapiens	96.05	0.00e+00	726.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	95.53	0.00e+00	717.00
IUUC-Lch-049795	Latimeria chalumnae	86.05	0.00e+00	667.00
IUUC-Loc-051985	Lepisosteus oculatus	86.05	0.00e+00	643.00
IUUC-Laf-054228	Loxodonta africana	92.89	0.00e+00	710.00
IUUC-Mcc-055402	Macaca mulatta	95.79	0.00e+00	724.00
IUUC-Mga-059374	Meleagris gallopavo	89.47	0.00e+00	695.00
IUUC-Mmr-061453	Microcebus murinus	95.53	0.00e+00	724.00
IUUC-Mdo-063080	Monodelphis domestica	88.68	0.00e+00	691.00
IUUC-Mpu-066815	Mustela putorius furo	94.74	0.00e+00	719.00
IUUC-Mlu-067132	Myotis lucifugus	92.79	8.00e-157	545.00
IUUC-Nle-069371	Nomascus leucogenys	96.05	0.00e+00	726.00
IUUC-Opr-070948	Ochotona princeps	94.69	0.00e+00	695.00
IUUC-Ont-071410	Oreochromis niloticus	74.44	1.00e-159	555.00
IUUC-Oan-073304	Ornithorhynchus anatinus	87.58	2.00e-155	541.00
IUUC-Ocu-074783	Oryctolagus cuniculus	95.26	0.00e+00	716.00
IUUC-Ola-086808	Oryzias latipes	72.84	1.00e-157	549.00
IUUC-Oga-088391	Otolemur garnettii	96.05	0.00e+00	720.00
IUUC-Oar-090025	Ovis aries	80.79	4.00e-166	577.00
IUUC-Ptr-090975	Pan troglodytes	96.05	0.00e+00	726.00
IUUC-Pan-092287	Papio anubis	95.79	0.00e+00	724.00
IUUC-Psi-093413	Pelodiscus sinensis	89.74	0.00e+00	697.00
IUUC-Pfo-097129	Poecilia formosa	75.95	5.00e-165	573.00
IUUC-Pab-098756	Pongo abelii	96.05	0.00e+00	726.00
IUUC-Pca-100235	Procavia capensis	79.47	2.00e-178	618.00
IUUC-Pva-102294	Pteropus vampyrus	91.58	0.00e+00	684.00
IUUC-Rno-105090	Rattus norvegicus	99.74	0.00e+00	739.00
IUUC-Sha-107521	Sarcophilus harrisii	89.21	0.00e+00	694.00
IUUC-Sar-113697	Sorex araneus	88.54	0.00e+00	661.00
IUUC-Ssc-115958	Sus scrofa	87.03	6.00e-160	556.00
IUUC-Tgu-116559	Taeniopygia guttata	87.37	0.00e+00	670.00
IUUC-Tru-117677	Takifugu rubripes	75.95	3.00e-163	568.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.23	2.00e-163	568.00
IUUC-Tbe-127931	Tupaia belangeri	93.99	1.00e-174	605.00
IUUC-Ttr-128993	Tursiops truncatus	87.63	0.00e+00	642.00
IUUC-Xtr-132543	Xenopus tropicalis	82.94	0.00e+00	653.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence