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Tag Content
UUCD2 ID IUUC-Aml-001459
UUCD1 version UUC-AiM-00472
Ensembl Protein ID ENSAMEP00000007152.1
UniProt Accession G1LJP5; G1LJP5_AILME
Genbank Protein ID ENSAMEP00000007152
Protein Name Uncharacterized protein
Genbank Nucleotide ID ACTA01073277
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000006728.1 ENSAMET00000007454.1 ENSAMEP00000007152.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.10e-127 426.1 420 752
Active Site
Position(s) Description Evidence
721 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 420  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 507
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 508  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++idv+d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 593  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDVSDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 680
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 681  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 752
           ***************************99999**************************************76 PP
   
Organism Ailuropoda melanoleuca
Protein Sequence
(Fasta)
LAEIISRFFF PLQIQFSVLC AKNLAKKDFF RLPDPFAKIV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYVG KTDSITISVW NHKKIHKKQG AGFLGCARLL SNAISRLKDT GYQRLDLCKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-001459|E3,HECT|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGGCAGAGA TAATTTCTAG GTTTTTTTTC CCATTGCAAA TACAGACTTG TGTCTCAGTC 60
GTTTGTGCTG CTATAACAAA ATACCACAGA ATGCGTGGCT TAAATACATC TATTTCTCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-001459|E3,HECT|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004155 Anas platyrhynchos 89.00 0.00e+00 1395.00
IUUC-Aca-005238 Anolis carolinensis 90.41 0.00e+00 1402.00
IUUC-Ame-010901 Astyanax mexicanus 85.51 0.00e+00 1321.00
IUUC-Bta-013221 Bos taurus 92.33 0.00e+00 1350.00
IUUC-Cja-018985 Callithrix jacchus 89.96 0.00e+00 1425.00
IUUC-Cfa-020568 Canis familiaris 90.28 0.00e+00 1415.00
IUUC-Cpo-022531 Cavia porcellus 89.45 0.00e+00 1415.00
IUUC-Csa-024145 Chlorocebus sabaeus 93.18 0.00e+00 1442.00
IUUC-Cho-024963 Choloepus hoffmanni 72.73 0.00e+00 891.00
IUUC-Dre-028341 Danio rerio 85.66 0.00e+00 1328.00
IUUC-Dno-029705 Dasypus novemcinctus 89.88 0.00e+00 1387.00
IUUC-Eca-034125 Equus caballus 90.27 0.00e+00 1416.00
IUUC-Fca-035905 Felis catus 93.27 0.00e+00 1428.00
IUUC-Fal-037336 Ficedula albicollis 91.50 0.00e+00 1398.00
IUUC-Gmo-039486 Gadus morhua 79.17 0.00e+00 850.00
IUUC-Gga-040218 Gallus gallus 90.30 0.00e+00 1405.00
IUUC-Gac-041707 Gasterosteus aculeatus 79.31 0.00e+00 1218.00
IUUC-Ggo-045408 Gorilla gorilla 84.73 0.00e+00 1311.00
IUUC-Hsa-045878 Homo sapiens 89.83 0.00e+00 1424.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 90.26 0.00e+00 1415.00
IUUC-Loc-052628 Lepisosteus oculatus 84.66 0.00e+00 1332.00
IUUC-Laf-053644 Loxodonta africana 93.40 0.00e+00 1398.00
IUUC-Mcc-055479 Macaca mulatta 84.95 0.00e+00 1278.00
IUUC-Mga-059723 Meleagris gallopavo 91.83 0.00e+00 1397.00
IUUC-Mdo-063005 Monodelphis domestica 92.01 0.00e+00 1423.00
IUUC-Mmu-063634 Mus musculus 92.28 0.00e+00 1404.00
IUUC-Mpu-065898 Mustela putorius furo 92.97 0.00e+00 1426.00
IUUC-Mlu-067584 Myotis lucifugus 90.17 0.00e+00 1417.00
IUUC-Nle-069033 Nomascus leucogenys 90.40 0.00e+00 1419.00
IUUC-Ont-072265 Oreochromis niloticus 78.23 0.00e+00 1232.00
IUUC-Oan-073621 Ornithorhynchus anatinus 92.31 0.00e+00 1443.00
IUUC-Ocu-073960 Oryctolagus cuniculus 89.13 0.00e+00 1386.00
IUUC-Oga-088579 Otolemur garnettii 89.83 0.00e+00 1421.00
IUUC-Oar-090396 Ovis aries 88.26 0.00e+00 1318.00
IUUC-Ptr-091624 Pan troglodytes 89.83 0.00e+00 1424.00
IUUC-Pan-092479 Papio anubis 90.17 0.00e+00 1419.00
IUUC-Ppa-095250 Physcomitrella patens 44.57 6.00e-83 301.00
IUUC-Pfo-097203 Poecilia formosa 80.05 0.00e+00 1248.00
IUUC-Pab-097540 Pongo abelii 89.25 0.00e+00 1352.00
IUUC-Pca-100379 Procavia capensis 72.73 0.00e+00 639.00
IUUC-Rno-105396 Rattus norvegicus 92.28 0.00e+00 1404.00
IUUC-Sha-107216 Sarcophilus harrisii 88.52 0.00e+00 1409.00
IUUC-Ssc-116413 Sus scrofa 91.99 0.00e+00 1386.00
IUUC-Tgu-116723 Taeniopygia guttata 88.37 0.00e+00 1370.00
IUUC-Tru-117843 Takifugu rubripes 81.38 0.00e+00 1256.00
IUUC-Tsy-119455 Tarsius syrichta 88.52 0.00e+00 1323.00
IUUC-Tni-120829 Tetraodon nigroviridis 79.95 0.00e+00 1199.00
IUUC-Tbe-127879 Tupaia belangeri 77.19 0.00e+00 1154.00
IUUC-Ttr-128423 Tursiops truncatus 88.96 0.00e+00 1335.00
IUUC-Xtr-132237 Xenopus tropicalis 82.99 0.00e+00 1322.00
Created Date 25-Jun-2017

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