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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047034
UUCD1 version UUC-HoS-00217
Ensembl Protein ID ENSP00000343273.4
UniProt Accession Q8IXQ5; A4D144; B7Z5I9; G5E9G3; Q7Z765; Q96MV2; Q9BQF8; Q9UDQ9; KLHL7_HUMAN
Genbank Protein ID AAF27196.1; CAB66532.1; BAB71175.1; BAH12925.1; ABQ59041.1; AAO21916.1; EAL24261.1; EAW93770.1; EAW93773.1; EAW93774.1; AAH09555.1; AAH39585.1
Protein Name Kelch-like protein 7
Genbank Nucleotide ID AF111113; AL136597; AK056390; AK299006; EF560731; AC005082; AC073992; CH471073; CH471073; CH471073; BC009555; BC039585
Gene Name KLHL7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122550.17 ENST00000339077.9 ENSP00000343273.4
ENSG00000122550.17 ENST00000322275.9 ENSP00000323270.5
ENSG00000122550.17 ENST00000410047.1 ENSP00000386999.1
ENSG00000122550.17 ENST00000414163.1 ENSP00000404181.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 19520207
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.80e-18 67.3 44 110
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.70e-14 51.6 144 174
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dvil v++++++ah++vLaa+S++F+ +f++++ esk + +ve+kd +p+  ++l++F Yt +++ n
   Q: 44   CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESK-SFEVELKDAEPDIIEQLVEFAYTARISVN 110
           9*************************************.*************************9876 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           +Nclgi  +A+++dcp+Lk  a+dfi++hF+
   Q: 144  SNCLGISVLAECLDCPELKATADDFIHQHFT 174
           8*****************************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
Protein Sequence
(Fasta)
MAASGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ KTLCDVILMV QERKIPAHRV 60
VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047034|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGTGCGCAG GCTCCTGGGC AGGGCTCGGG TTCTGCCCGG GGACGCAGCC CAGTTGGTAG 60
CGTCGCTCCC TGAGCGTTTC TAAGGGGGCC GCCCGGCCTT GTCTTTCGGC AGTGGCCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047034|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0682--Retinitis pigmentosa
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030599--KLHL7
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0016567--P:protein ubiquitination
KEGG hsa:55975
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001981 Ailuropoda melanoleuca 99.83 0.00e+00 1175.00
IUUC-Apl-003183 Anas platyrhynchos 98.56 0.00e+00 1160.00
IUUC-Aca-004273 Anolis carolinensis 98.20 0.00e+00 1161.00
IUUC-Ame-011343 Astyanax mexicanus 83.36 0.00e+00 969.00
IUUC-Bta-012785 Bos taurus 99.66 0.00e+00 1172.00
IUUC-Cja-019038 Callithrix jacchus 99.83 0.00e+00 1199.00
IUUC-Cfa-020774 Canis familiaris 99.82 0.00e+00 1147.00
IUUC-Cpo-021716 Cavia porcellus 99.66 0.00e+00 1169.00
IUUC-Csa-023029 Chlorocebus sabaeus 100.00 0.00e+00 1177.00
IUUC-Cho-024947 Choloepus hoffmanni 76.96 0.00e+00 849.00
IUUC-Dre-028014 Danio rerio 83.40 0.00e+00 878.00
IUUC-Dno-029946 Dasypus novemcinctus 99.66 0.00e+00 1174.00
IUUC-Dor-030916 Dipodomys ordii 83.20 7.00e-177 613.00
IUUC-Dse-031294 Dothistroma septosporum 32.95 3.00e-06 44.30
IUUC-Ete-032454 Echinops telfairi 94.01 0.00e+00 638.00
IUUC-Eca-034041 Equus caballus 99.49 0.00e+00 1173.00
IUUC-Eeu-034627 Erinaceus europaeus 98.98 0.00e+00 972.00
IUUC-Fca-035854 Felis catus 99.83 0.00e+00 1175.00
IUUC-Fal-036883 Ficedula albicollis 98.12 0.00e+00 1160.00
IUUC-Gmo-038902 Gadus morhua 78.74 0.00e+00 898.00
IUUC-Gga-040866 Gallus gallus 98.29 0.00e+00 1167.00
IUUC-Gac-041428 Gasterosteus aculeatus 78.14 0.00e+00 940.00
IUUC-Ggo-044846 Gorilla gorilla 93.86 0.00e+00 1082.00
IUUC-Itr-048807 Ictidomys tridecemlineatus 99.62 6.00e-141 493.00
IUUC-Lch-049815 Latimeria chalumnae 89.84 0.00e+00 1055.00
IUUC-Loc-052232 Lepisosteus oculatus 84.76 0.00e+00 914.00
IUUC-Laf-053520 Loxodonta africana 99.49 0.00e+00 1171.00
IUUC-Mcc-055237 Macaca mulatta 99.83 0.00e+00 1177.00
IUUC-Meu-056095 Macropus eugenii 92.90 1.00e-175 608.00
IUUC-Mga-059927 Meleagris gallopavo 98.29 0.00e+00 1167.00
IUUC-Mvi-060550 Microbotryum violaceum 39.02 9.20e-01 29.60
IUUC-Mmr-060974 Microcebus murinus 98.57 0.00e+00 1155.00
IUUC-Mdo-062729 Monodelphis domestica 92.01 0.00e+00 1117.00
IUUC-Mmu-063841 Mus musculus 97.78 0.00e+00 1156.00
IUUC-Mpu-066524 Mustela putorius furo 97.01 0.00e+00 1165.00
IUUC-Mlu-067215 Myotis lucifugus 99.82 0.00e+00 1174.00
IUUC-Ncr-068856 Neurospora crassa 28.71 3.00e-04 39.30
IUUC-Nle-069341 Nomascus leucogenys 100.00 0.00e+00 1177.00
IUUC-Opr-070269 Ochotona princeps 99.49 0.00e+00 1172.00
IUUC-Ont-071551 Oreochromis niloticus 79.79 0.00e+00 944.00
IUUC-Oan-072718 Ornithorhynchus anatinus 99.27 0.00e+00 1150.00
IUUC-Ocu-074287 Oryctolagus cuniculus 100.00 0.00e+00 1177.00
IUUC-Ola-086718 Oryzias latipes 78.37 0.00e+00 955.00
IUUC-Oga-088757 Otolemur garnettii 99.49 0.00e+00 1174.00
IUUC-Oar-090309 Ovis aries 99.66 0.00e+00 1172.00
IUUC-Ptr-090509 Pan troglodytes 100.00 0.00e+00 1177.00
IUUC-Pan-092929 Papio anubis 100.00 0.00e+00 1177.00
IUUC-Psi-092941 Pelodiscus sinensis 98.74 0.00e+00 1162.00
IUUC-Pfo-097421 Poecilia formosa 79.39 0.00e+00 931.00
IUUC-Pab-097792 Pongo abelii 100.00 0.00e+00 1177.00
IUUC-Pca-101033 Procavia capensis 90.04 0.00e+00 856.00
IUUC-Pva-102364 Pteropus vampyrus 89.42 0.00e+00 1030.00
IUUC-Rno-105596 Rattus norvegicus 97.95 0.00e+00 1158.00
IUUC-Sha-106815 Sarcophilus harrisii 99.26 0.00e+00 1127.00
IUUC-Smo-109320 Selaginella moellendorffii 26.72 1.00e-15 79.00
IUUC-Sar-113305 Sorex araneus 99.15 0.00e+00 1170.00
IUUC-Ssc-115871 Sus scrofa 95.86 2.00e-168 584.00
IUUC-Tgu-116940 Taeniopygia guttata 97.78 0.00e+00 1156.00
IUUC-Tru-118682 Takifugu rubripes 78.69 0.00e+00 958.00
IUUC-Tsy-118787 Tarsius syrichta 99.21 0.00e+00 803.00
IUUC-Tni-120224 Tetraodon nigroviridis 79.26 0.00e+00 961.00
IUUC-Tbe-127633 Tupaia belangeri 57.05 7.00e-88 317.00
IUUC-Ttr-128500 Tursiops truncatus 98.39 0.00e+00 1157.00
IUUC-Vpa-130512 Vicugna pacos 97.26 0.00e+00 1118.00
IUUC-Xtr-131983 Xenopus tropicalis 96.95 0.00e+00 1146.00
Created Date 25-Jun-2017

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