iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004434

UUCD1 version

UUC-AnC-00993

Ensembl Protein ID

ENSACAP00000013876.3

UniProt Accession

G1KPI7; G1KPI7_ANOCA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014125.3	ENSACAT00000014160.3	ENSACAP00000013876.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-97	327.0	270	677

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenp......................................... 42
           tGl+NlgNtCYmNS+LQ+Ls++  +re++l+      +         +                                         
   Q: 270  TGLRNLGNTCYMNSILQVLSHLLIFRECFLKldlnqtQ---------Ellaaaangktrssskhppspgsifhlnkshikgkesyarrt 349
           7******************************6553220.........222345567777888888999999999999999999999999 PP
   S: 43   ........................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeel 107
                                   +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el
   Q: 350  svasglsggasnrrnmeliqpkepSSKYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQEL 438
           99999999999999999988877777777************************************************************ PP
   S: 108  kkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slq 188
                    e+  ++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+
   Q: 439  ---------ETARTKCPALIPTSQRKLIKQVLNVVNTIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYHCNGKettcqypcMLT 518
           .........555566667888899**********************************************9999887799999999*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           ++L++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v+f + L+++p+c+
   Q: 519  EMLAKFTETEALEGKI-YACDQCNTKRRkfsskpvilseAQKQLMVCQLPQVLRLHLKRFRWSGR-NHREKIGVHVTFSQILNMEPYCC 605
           *************965.*******99999*********************************997.8889******************* PP
   S: 267  speekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++ k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + +++eev++   ++aY+lfY++
   Q: 606  RESLKSLVpdCFIYDLSAVVMHHGkGFGSGHYTAYCYNSDGGfWVHCNDSKLNMCTMEEVCK---AQAYILFYTQ 677
           *9988877779***************************9999********************...********98 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MDKCKHVGRL RLAQDHSIVN PQKWHCMVCN TTESVWACLS CSHVACGRYI EEHALKHFQE 60
SNHPVALEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIKSQNYDCT TRSGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACAATGC AAGAACTAGA AAACTGGTTT CTGTAGAATT TTGACAGCAT TGAAGTATTA 60
ACAATGGATA AGTGTAAGCA TGTAGGACGT CTTCGACTTG CCCAAGATCA TTCCATTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	72.07	0.00e+00	1020.00
IUUC-Apl-003673	Anas platyrhynchos	83.38	0.00e+00	1134.00
IUUC-Ame-010986	Astyanax mexicanus	68.66	0.00e+00	904.00
IUUC-Bta-012774	Bos taurus	72.77	0.00e+00	1034.00
IUUC-Cja-019619	Callithrix jacchus	70.57	0.00e+00	1018.00
IUUC-Cfa-020957	Canis familiaris	71.65	0.00e+00	1032.00
IUUC-Csa-023177	Chlorocebus sabaeus	73.76	0.00e+00	1010.00
IUUC-Cho-024877	Choloepus hoffmanni	68.54	8.00e-180	623.00
IUUC-Cin-025587	Ciona intestinalis	47.35	2.00e-110	393.00
IUUC-Csv-025814	Ciona savignyi	44.84	8.00e-154	537.00
IUUC-Dre-027878	Danio rerio	69.12	0.00e+00	881.00
IUUC-Dno-029832	Dasypus novemcinctus	71.97	0.00e+00	1023.00
IUUC-Ete-032627	Echinops telfairi	71.02	0.00e+00	996.00
IUUC-Eca-033863	Equus caballus	71.09	0.00e+00	1006.00
IUUC-Eeu-035225	Erinaceus europaeus	67.97	0.00e+00	954.00
IUUC-Fca-036288	Felis catus	71.79	0.00e+00	1016.00
IUUC-Fal-037207	Ficedula albicollis	80.53	0.00e+00	1111.00
IUUC-Gga-040457	Gallus gallus	81.84	0.00e+00	1094.00
IUUC-Ggo-044926	Gorilla gorilla	74.05	0.00e+00	1008.00
IUUC-Hsa-046079	Homo sapiens	74.20	0.00e+00	1008.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	73.47	0.00e+00	1007.00
IUUC-Lch-050260	Latimeria chalumnae	75.80	0.00e+00	975.00
IUUC-Loc-051981	Lepisosteus oculatus	81.06	0.00e+00	712.00
IUUC-Laf-054491	Loxodonta africana	73.25	0.00e+00	991.00
IUUC-Mcc-055694	Macaca mulatta	73.62	0.00e+00	1006.00
IUUC-Mga-059523	Meleagris gallopavo	83.24	0.00e+00	1118.00
IUUC-Mmr-060885	Microcebus murinus	75.04	0.00e+00	1033.00
IUUC-Mdo-063018	Monodelphis domestica	81.44	0.00e+00	1110.00
IUUC-Mmu-064012	Mus musculus	64.75	0.00e+00	891.00
IUUC-Mpu-066207	Mustela putorius furo	71.47	0.00e+00	1031.00
IUUC-Mlu-066929	Myotis lucifugus	70.81	0.00e+00	963.00
IUUC-Opr-070375	Ochotona princeps	69.39	0.00e+00	928.00
IUUC-Ont-071637	Oreochromis niloticus	68.92	0.00e+00	898.00
IUUC-Oan-073030	Ornithorhynchus anatinus	79.86	0.00e+00	872.00
IUUC-Ocu-074836	Oryctolagus cuniculus	70.80	0.00e+00	972.00
IUUC-Oga-088367	Otolemur garnettii	73.54	0.00e+00	1014.00
IUUC-Oar-089953	Ovis aries	72.80	0.00e+00	1034.00
IUUC-Ptr-090980	Pan troglodytes	74.20	0.00e+00	1008.00
IUUC-Pan-092748	Papio anubis	74.16	0.00e+00	1017.00
IUUC-Psi-094078	Pelodiscus sinensis	84.92	0.00e+00	947.00
IUUC-Pma-094155	Petromyzon marinus	71.22	2.00e-81	295.00
IUUC-Pab-098514	Pongo abelii	74.78	0.00e+00	1019.00
IUUC-Pva-102984	Pteropus vampyrus	73.39	0.00e+00	1041.00
IUUC-Rno-106019	Rattus norvegicus	66.11	0.00e+00	926.00
IUUC-Sha-106965	Sarcophilus harrisii	79.69	0.00e+00	1100.00
IUUC-Ssc-115299	Sus scrofa	72.87	0.00e+00	1037.00
IUUC-Tgu-117160	Taeniopygia guttata	83.02	0.00e+00	1111.00
IUUC-Tru-118156	Takifugu rubripes	67.05	0.00e+00	879.00
IUUC-Tni-119733	Tetraodon nigroviridis	64.76	0.00e+00	884.00
IUUC-Tbe-128084	Tupaia belangeri	69.18	0.00e+00	984.00
IUUC-Ttr-128928	Tursiops truncatus	72.44	0.00e+00	1041.00
IUUC-Vpa-130706	Vicugna pacos	72.29	0.00e+00	1031.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence