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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063184
UUCD1 version UUC-MuM-00946
Ensembl Protein ID ENSMUSP00000058251.1
UniProt Accession Q9D9R0; Q0VG32; Q52KL4; Q8C7F2; RN125_MOUSE
Genbank Protein ID BAB24656.1; BAC34234.1; AAH94290.1; AAI16884.1; AAI16888.1
Protein Name E3 ubiquitin-protein ligase RNF125; RING finger protein 125
Genbank Nucleotide ID AK006569; AK050395; AC138611; BC116883; BC116887
Gene Name Rnf125
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033107.5 ENSMUST00000050004.1 ENSMUSP00000058251.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 85.71 2.00e-57 218.00 IUUC-Hsa-046518
UBD/Alpha-Helix/UIM 85.71 2.00e-57 218.00 IUUC-Hsa-046518
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
Protein Sequence
(Fasta)
MKSEYQNCAE CGTLVCLSDM RAHIRTCEKY IDKYGPLLEL GDTTARCVCP FCQRELDEDC 60
LLDHCIIHHR SERRPVFCPL CHSRPDESPS TFNGSLIRHL QVSHTLFYDD FIDFDIIEEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063184|E3,RING;UBD,UIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCCTTTGGC TCAGAGACCC CTCTGCCCTG CTGCAGAGGA CTGAGATTTA AGGTGGTGGC 60
CAACATGGCC ACCTTTTACT CTTCCCCTCA CTGTCAAATG CCTCTGTCCA CTCCTTCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063184|E3,RING;UBD,UIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0391--Immunity
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0043231--C:intracellular membrane-bounded organelle
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:67664
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001992 Ailuropoda melanoleuca 81.43 6.00e-66 243.00
IUUC-Aca-004839 Anolis carolinensis 57.04 1.00e-44 171.00
IUUC-Bta-012827 Bos taurus 81.43 5.00e-65 240.00
IUUC-Bol-015340 Brassica oleracea 38.24 7.40e-01 26.20
IUUC-Cja-018794 Callithrix jacchus 84.29 1.00e-67 249.00
IUUC-Cfa-021234 Canis familiaris 82.86 4.00e-66 244.00
IUUC-Cpo-022412 Cavia porcellus 79.29 1.00e-63 236.00
IUUC-Csa-023406 Chlorocebus sabaeus 86.43 1.00e-68 252.00
IUUC-Cho-024427 Choloepus hoffmanni 67.86 1.00e-48 185.00
IUUC-Dno-030085 Dasypus novemcinctus 85.00 2.00e-68 251.00
IUUC-Dor-030911 Dipodomys ordii 84.13 2.00e-47 181.00
IUUC-Ete-032469 Echinops telfairi 80.71 2.00e-64 238.00
IUUC-Eca-034352 Equus caballus 82.14 8.00e-67 246.00
IUUC-Eeu-034889 Erinaceus europaeus 62.86 3.00e-44 171.00
IUUC-Fca-036116 Felis catus 82.86 3.00e-66 244.00
IUUC-Hsa-046518 Homo sapiens 85.71 1.00e-67 249.00
IUUC-Itr-048344 Ictidomys tridecemlineatus 86.43 4.00e-69 253.00
IUUC-Laf-053363 Loxodonta africana 82.39 1.00e-65 242.00
IUUC-Meu-056101 Macropus eugenii 70.71 6.00e-53 200.00
IUUC-Mdo-062046 Monodelphis domestica 70.71 1.00e-55 209.00
IUUC-Mpu-065708 Mustela putorius furo 82.14 1.00e-65 242.00
IUUC-Mlu-067561 Myotis lucifugus 82.86 1.00e-66 245.00
IUUC-Nle-069665 Nomascus leucogenys 81.15 4.00e-56 210.00
IUUC-Opr-070301 Ochotona princeps 65.71 1.00e-46 179.00
IUUC-Ocu-074562 Oryctolagus cuniculus 83.33 4.00e-59 219.00
IUUC-Oga-088958 Otolemur garnettii 86.43 5.00e-69 253.00
IUUC-Oar-089541 Ovis aries 82.86 1.00e-66 245.00
IUUC-Ptr-090989 Pan troglodytes 86.43 1.00e-68 252.00
IUUC-Pan-092372 Papio anubis 86.43 5.00e-69 253.00
IUUC-Pab-098718 Pongo abelii 64.29 5.00e-44 170.00
IUUC-Pca-100453 Procavia capensis 82.14 6.00e-65 240.00
IUUC-Pva-102931 Pteropus vampyrus 83.57 3.00e-66 244.00
IUUC-Rno-105771 Rattus norvegicus 95.71 1.00e-66 245.00
IUUC-Sha-107557 Sarcophilus harrisii 69.29 8.00e-57 213.00
IUUC-Sar-113435 Sorex araneus 81.75 1.00e-58 218.00
IUUC-Ssc-116388 Sus scrofa 82.14 2.00e-66 245.00
IUUC-Tsy-119439 Tarsius syrichta 85.00 1.00e-68 251.00
IUUC-Tbe-127417 Tupaia belangeri 59.82 7.00e-32 130.00
IUUC-Ttr-129212 Tursiops truncatus 82.86 7.00e-67 246.00
IUUC-Vpa-130153 Vicugna pacos 84.29 6.00e-67 246.00
Created Date 25-Jun-2017

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