iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013097

Ensembl Protein ID

ENSBTAP00000017565.5

UniProt Accession

Q9XT96; Q2KI10; PSN2_BOVIN

Genbank Protein ID

AAD39024.1; AAI12812.1

Protein Name

Presenilin-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit

Genbank Nucleotide ID

AF038937; BC112811

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013197.5	ENSBTAT00000017565.5	ENSBTAP00000017565.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.50e-08	33.5	279	317

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 279  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 317
           89********************************99986 PP

Organism

Bos taurus

Functional Description
(View)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity).

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRS CQDGRQGLED GESAAQWRSQ ESEEDHEEED 60
PDRYVCSGVP GRPPGLEEEL TLKYGAKHVI MLFVPVTLCM IVVVATIKSV RFYTEKNGQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGAGCTG CGCGGCGGAG CAGGTGAGCC GGCTGGATGG GGCGCGCGGA TGGGGGCCCG 60
ATCGCCCGGC GTTCGAAGGG CGCGAGGTGG AGCTGCACTC CGCAGGCGGG GCCTTGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

bta:282010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	88.64	0.00e+00	627.00
IUUC-Apl-003959	Anas platyrhynchos	77.85	3.00e-164	571.00
IUUC-Aca-005160	Anolis carolinensis	75.63	3.00e-158	551.00
IUUC-Ang-009768	Aspergillus niger	54.55	1.10e+00	28.50
IUUC-Ame-010686	Astyanax mexicanus	78.65	9.00e-147	513.00
IUUC-Bra-017580	Brassica rapa	57.47	3.00e-17	82.80
IUUC-Cja-018824	Callithrix jacchus	94.88	0.00e+00	707.00
IUUC-Cfa-020253	Canis familiaris	95.55	0.00e+00	721.00
IUUC-Cpo-021401	Cavia porcellus	95.32	0.00e+00	714.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	4.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	96.44	0.00e+00	728.00
IUUC-Dre-028526	Danio rerio	69.54	2.00e-144	505.00
IUUC-Dor-031127	Dipodomys ordii	90.65	0.00e+00	668.00
IUUC-Ete-033081	Echinops telfairi	84.40	5.00e-94	338.00
IUUC-Eca-034387	Equus caballus	95.32	0.00e+00	697.00
IUUC-Eeu-034846	Erinaceus europaeus	80.35	6.00e-149	520.00
IUUC-Fca-035396	Felis catus	94.42	0.00e+00	756.00
IUUC-Fal-037457	Ficedula albicollis	76.74	3.00e-162	564.00
IUUC-Gmo-038550	Gadus morhua	82.76	9.00e-106	376.00
IUUC-Gga-040706	Gallus gallus	77.63	2.00e-158	552.00
IUUC-Gac-042511	Gasterosteus aculeatus	65.12	1.00e-128	452.00
IUUC-Ggo-045338	Gorilla gorilla	96.66	0.00e+00	728.00
IUUC-Hsa-046455	Homo sapiens	96.66	0.00e+00	728.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.99	0.00e+00	724.00
IUUC-Lch-049638	Latimeria chalumnae	67.88	1.00e-144	506.00
IUUC-Loc-052427	Lepisosteus oculatus	74.28	1.00e-154	539.00
IUUC-Laf-053758	Loxodonta africana	89.18	0.00e+00	700.00
IUUC-Mcc-054755	Macaca mulatta	96.66	0.00e+00	728.00
IUUC-Mmr-060890	Microcebus murinus	94.65	0.00e+00	708.00
IUUC-Mdo-062197	Monodelphis domestica	80.13	4.00e-175	607.00
IUUC-Mmu-063823	Mus musculus	94.65	0.00e+00	714.00
IUUC-Mac-064858	Musa acuminata	43.86	8.00e-23	100.00
IUUC-Mpu-066181	Mustela putorius furo	95.55	0.00e+00	721.00
IUUC-Nle-069596	Nomascus leucogenys	96.21	0.00e+00	677.00
IUUC-Opr-070344	Ochotona princeps	94.43	0.00e+00	741.00
IUUC-Ont-071867	Oreochromis niloticus	70.40	2.00e-133	469.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.70	2.00e-153	535.00
IUUC-Ocu-074652	Oryctolagus cuniculus	93.99	0.00e+00	701.00
IUUC-Obr-076302	Oryza brachyantha	36.96	8.00e-17	81.60
IUUC-Oin-079244	Oryza indica	37.68	9.00e-17	81.60
IUUC-Oni-082057	Oryza nivara	37.68	9.00e-17	81.30
IUUC-Ola-086707	Oryzias latipes	66.67	1.00e-104	372.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.22	5.00e-47	181.00
IUUC-Oga-088560	Otolemur garnettii	94.47	0.00e+00	701.00
IUUC-Oar-089200	Ovis aries	98.66	0.00e+00	715.00
IUUC-Ptr-090569	Pan troglodytes	96.44	0.00e+00	726.00
IUUC-Pan-091742	Papio anubis	96.66	0.00e+00	727.00
IUUC-Psi-093297	Pelodiscus sinensis	77.62	3.00e-133	468.00
IUUC-Pma-094612	Petromyzon marinus	77.57	5.00e-128	450.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	1.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	96.44	0.00e+00	728.00
IUUC-Pca-101120	Procavia capensis	92.20	0.00e+00	690.00
IUUC-Pva-102934	Pteropus vampyrus	86.41	0.00e+00	674.00
IUUC-Rno-106052	Rattus norvegicus	93.54	0.00e+00	724.00
IUUC-Sha-106876	Sarcophilus harrisii	79.96	9.00e-174	602.00
IUUC-Ssc-115380	Sus scrofa	97.77	0.00e+00	756.00
IUUC-Tgu-117280	Taeniopygia guttata	77.39	6.00e-163	566.00
IUUC-Tbe-127632	Tupaia belangeri	94.43	6.00e-180	623.00
IUUC-Ttr-129008	Tursiops truncatus	95.32	0.00e+00	710.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence