iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092093

Ensembl Protein ID

ENSPANP00000009962.1

UniProt Accession

A0A096NB45; A0A096NB45_PAPAN

Genbank Protein ID

ENSPANP00000009962

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01058459

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000019938.1	ENSPANT00000019962.1	ENSPANP00000009962.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.40e-13	48.5	167	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g  G fP+n+v++++
   Q: 167  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNG-TGWFPSNYVREVK 220
           78999*********************7..999*******..5666.7*********996 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
RSESECLSNI REFLRGCGAS LRLETFDAND LYQGQNFNKV LSSLVTLNKV TADIGLGSDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCTTCTC CTGGCGGTGA TGTCATTGGG CGACGGCGGC CGAGGCCGGG GGGCGGCGGC 60
GGGGGCGGCG GCGGGCGCCC GCAGGTTCCC GAGCCGCTCC TGAGAAAGCG CCTGACAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	81.42	0.00e+00	1146.00
IUUC-Aca-004591	Anolis carolinensis	83.29	0.00e+00	1258.00
IUUC-Ame-010759	Astyanax mexicanus	70.01	0.00e+00	1149.00
IUUC-Bta-013328	Bos taurus	83.45	0.00e+00	1348.00
IUUC-Bci-013864	Botrytis cinerea	44.07	7.00e-11	63.20
IUUC-Cja-018742	Callithrix jacchus	84.91	0.00e+00	1073.00
IUUC-Cfa-020756	Canis familiaris	80.91	0.00e+00	973.00
IUUC-Cpo-021284	Cavia porcellus	84.82	0.00e+00	1282.00
IUUC-Csa-023162	Chlorocebus sabaeus	88.85	0.00e+00	1431.00
IUUC-Cho-024736	Choloepus hoffmanni	73.73	2.00e-172	598.00
IUUC-Dre-028646	Danio rerio	69.64	0.00e+00	1142.00
IUUC-Dno-029461	Dasypus novemcinctus	86.68	0.00e+00	1380.00
IUUC-Dor-030623	Dipodomys ordii	74.93	0.00e+00	940.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	795.00
IUUC-Eca-034137	Equus caballus	85.28	0.00e+00	1199.00
IUUC-Fca-035742	Felis catus	78.62	0.00e+00	952.00
IUUC-Fal-037205	Ficedula albicollis	82.49	0.00e+00	1038.00
IUUC-Gmo-039475	Gadus morhua	62.96	0.00e+00	971.00
IUUC-Gga-040539	Gallus gallus	78.55	0.00e+00	821.00
IUUC-Gac-042615	Gasterosteus aculeatus	60.46	0.00e+00	842.00
IUUC-Ggo-044470	Gorilla gorilla	81.76	0.00e+00	1178.00
IUUC-Hsa-046398	Homo sapiens	84.64	0.00e+00	1236.00
IUUC-Loc-052146	Lepisosteus oculatus	78.74	0.00e+00	1244.00
IUUC-Laf-053891	Loxodonta africana	82.55	0.00e+00	1290.00
IUUC-Mcc-055483	Macaca mulatta	84.77	0.00e+00	1238.00
IUUC-Mga-059410	Meleagris gallopavo	82.38	0.00e+00	1192.00
IUUC-Mmr-060758	Microcebus murinus	84.11	0.00e+00	1165.00
IUUC-Mdo-061900	Monodelphis domestica	81.97	0.00e+00	1125.00
IUUC-Mmu-063849	Mus musculus	84.17	0.00e+00	1150.00
IUUC-Mpu-065876	Mustela putorius furo	79.91	0.00e+00	967.00
IUUC-Mlu-067970	Myotis lucifugus	85.03	0.00e+00	1201.00
IUUC-Nle-069685	Nomascus leucogenys	83.25	0.00e+00	885.00
IUUC-Opr-071132	Ochotona princeps	63.84	4.00e-152	531.00
IUUC-Ont-071815	Oreochromis niloticus	70.00	0.00e+00	1133.00
IUUC-Oan-073057	Ornithorhynchus anatinus	81.65	0.00e+00	1018.00
IUUC-Ola-086663	Oryzias latipes	68.90	0.00e+00	742.00
IUUC-Oga-088103	Otolemur garnettii	82.75	0.00e+00	1160.00
IUUC-Ptr-091162	Pan troglodytes	83.07	0.00e+00	1125.00
IUUC-Pma-094701	Petromyzon marinus	61.37	6.00e-119	420.00
IUUC-Pfo-096736	Poecilia formosa	62.39	0.00e+00	962.00
IUUC-Pab-097641	Pongo abelii	86.28	0.00e+00	1189.00
IUUC-Pva-102819	Pteropus vampyrus	81.67	0.00e+00	1125.00
IUUC-Rno-106099	Rattus norvegicus	85.71	0.00e+00	1323.00
IUUC-Sha-106845	Sarcophilus harrisii	79.41	0.00e+00	957.00
IUUC-Ssc-116036	Sus scrofa	80.19	0.00e+00	954.00
IUUC-Tgu-117498	Taeniopygia guttata	81.29	0.00e+00	1273.00
IUUC-Tru-118278	Takifugu rubripes	66.02	0.00e+00	961.00
IUUC-Tsy-118990	Tarsius syrichta	89.88	0.00e+00	902.00
IUUC-Tni-120852	Tetraodon nigroviridis	67.08	0.00e+00	877.00
IUUC-Ttr-128922	Tursiops truncatus	75.76	0.00e+00	972.00
IUUC-Xtr-132012	Xenopus tropicalis	77.32	0.00e+00	1092.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence