iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069465

Ensembl Protein ID

ENSNLEP00000016249.1

UniProt Accession

G1RSM6; G1RSM6_NOMLE

Genbank Protein ID

ENSNLEP00000016249

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01097685

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000013392.2	ENSNLET00000017082.1	ENSNLEP00000016249.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-11	43.6	812	863

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 812  ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 863
           67**********************************..9*************86 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGRVIS AVSRLSLHSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCAGT GGCGGCAGTG CGGCCGCTGG CTCATCGACT GCAAGGTCCT GCCGCCCAAC 60
CACCGGGTGG TGTGGCCCTC GGCCGTGGTC TTCGACCTGG CGCAGGCGCT GCGCGACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	85.46	0.00e+00	1325.00
IUUC-Apl-003262	Anas platyrhynchos	83.28	0.00e+00	1397.00
IUUC-Ath-007352	Arabidopsis thaliana	39.22	7.00e-04	39.30
IUUC-Ame-011608	Astyanax mexicanus	72.04	0.00e+00	1269.00
IUUC-Bta-013147	Bos taurus	85.08	0.00e+00	1180.00
IUUC-Cja-018877	Callithrix jacchus	86.30	0.00e+00	1281.00
IUUC-Cfa-020315	Canis familiaris	85.51	0.00e+00	1143.00
IUUC-Cpo-021543	Cavia porcellus	83.60	0.00e+00	1186.00
IUUC-Csa-024204	Chlorocebus sabaeus	88.96	0.00e+00	1495.00
IUUC-Dre-028308	Danio rerio	74.66	0.00e+00	1319.00
IUUC-Dno-029584	Dasypus novemcinctus	81.51	0.00e+00	1040.00
IUUC-Dor-031014	Dipodomys ordii	73.93	0.00e+00	1072.00
IUUC-Eca-033448	Equus caballus	84.76	0.00e+00	1431.00
IUUC-Eeu-035182	Erinaceus europaeus	73.88	5.00e-165	574.00
IUUC-Fca-035460	Felis catus	83.80	0.00e+00	1185.00
IUUC-Fal-036684	Ficedula albicollis	82.50	0.00e+00	1411.00
IUUC-Gmo-038816	Gadus morhua	68.03	0.00e+00	966.00
IUUC-Gga-040999	Gallus gallus	80.87	0.00e+00	1382.00
IUUC-Gac-041353	Gasterosteus aculeatus	69.34	0.00e+00	1016.00
IUUC-Ggo-044558	Gorilla gorilla	91.01	0.00e+00	1507.00
IUUC-Hsa-046208	Homo sapiens	90.90	0.00e+00	1505.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	84.33	0.00e+00	1097.00
IUUC-Loc-052827	Lepisosteus oculatus	75.42	0.00e+00	1328.00
IUUC-Laf-054009	Loxodonta africana	84.00	0.00e+00	1409.00
IUUC-Mcc-055054	Macaca mulatta	90.78	0.00e+00	1503.00
IUUC-Mga-060106	Meleagris gallopavo	83.98	0.00e+00	1414.00
IUUC-Mmr-061118	Microcebus murinus	87.06	0.00e+00	1463.00
IUUC-Mdo-062380	Monodelphis domestica	79.48	0.00e+00	1142.00
IUUC-Mmu-063135	Mus musculus	88.09	0.00e+00	1500.00
IUUC-Mpu-066135	Mustela putorius furo	82.38	0.00e+00	1284.00
IUUC-Ont-071945	Oreochromis niloticus	75.31	0.00e+00	1273.00
IUUC-Oan-073384	Ornithorhynchus anatinus	79.40	0.00e+00	1080.00
IUUC-Ola-087499	Oryzias latipes	68.78	0.00e+00	952.00
IUUC-Oga-088444	Otolemur garnettii	83.53	0.00e+00	1163.00
IUUC-Oar-089576	Ovis aries	80.05	0.00e+00	1077.00
IUUC-Ptr-090507	Pan troglodytes	91.94	0.00e+00	1511.00
IUUC-Pan-092325	Papio anubis	88.26	0.00e+00	1448.00
IUUC-Psi-094021	Pelodiscus sinensis	81.08	0.00e+00	1377.00
IUUC-Pfo-096732	Poecilia formosa	75.11	0.00e+00	1287.00
IUUC-Pab-098426	Pongo abelii	76.08	0.00e+00	1085.00
IUUC-Pca-100295	Procavia capensis	84.98	0.00e+00	1340.00
IUUC-Rno-105332	Rattus norvegicus	87.29	0.00e+00	1427.00
IUUC-Sha-106529	Sarcophilus harrisii	86.93	0.00e+00	1163.00
IUUC-Ssc-116176	Sus scrofa	85.59	0.00e+00	1313.00
IUUC-Tgu-116917	Taeniopygia guttata	83.00	0.00e+00	1273.00
IUUC-Tru-118398	Takifugu rubripes	74.84	0.00e+00	891.00
IUUC-Tni-120819	Tetraodon nigroviridis	72.89	0.00e+00	1078.00
IUUC-Xtr-132747	Xenopus tropicalis	72.71	0.00e+00	1223.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence