iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089576

Ensembl Protein ID

ENSOARP00000002905.1

UniProt Accession

W5NXK8; W5NXK8_SHEEP

Genbank Protein ID

ENSOARP00000002905

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01074260

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000002720.1	ENSOART00000002963.1	ENSOARP00000002905.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-18	66.2	672	723

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 672  ARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRVGWFPSTYVEE 723
           67**********************************..9*************86 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

EHGVGEDIYD CVPCEDDGDD IYEDIIRVEV QQPMKMGMTE DDKRNCCLLE IQETEAKYYR 60
TLEDIEKVGV AAGAARRPPA PRGPLPRQGL GAIAFRLAWG FKVHHSFLRA IDVSMMAGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCACGGCG TGGGCGAGGA CATCTACGAC TGCGTCCCGT GCGAGGATGA CGGGGACGAC 60
ATCTATGAGG ACATCATCAG GGTGGAGGTG CAGCAGCCCA TGGTGAGCCC CGCCCGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	87.92	0.00e+00	1190.00
IUUC-Apl-003262	Anas platyrhynchos	84.59	0.00e+00	1173.00
IUUC-Aca-004628	Anolis carolinensis	62.13	0.00e+00	792.00
IUUC-Ath-007352	Arabidopsis thaliana	37.10	2.00e-04	40.80
IUUC-Ame-011608	Astyanax mexicanus	74.22	0.00e+00	1087.00
IUUC-Bta-013147	Bos taurus	92.57	0.00e+00	1295.00
IUUC-Cja-018877	Callithrix jacchus	86.04	0.00e+00	1187.00
IUUC-Cfa-020315	Canis familiaris	88.47	0.00e+00	1202.00
IUUC-Cpo-021543	Cavia porcellus	86.71	0.00e+00	1194.00
IUUC-Csa-024204	Chlorocebus sabaeus	85.30	0.00e+00	1200.00
IUUC-Dre-028308	Danio rerio	74.53	0.00e+00	1072.00
IUUC-Dno-029584	Dasypus novemcinctus	84.71	0.00e+00	1095.00
IUUC-Dor-031014	Dipodomys ordii	76.36	0.00e+00	993.00
IUUC-Eca-033448	Equus caballus	85.75	0.00e+00	1184.00
IUUC-Eeu-035182	Erinaceus europaeus	76.15	5.00e-136	478.00
IUUC-Fca-035460	Felis catus	88.72	0.00e+00	1233.00
IUUC-Fal-036684	Ficedula albicollis	83.58	0.00e+00	1170.00
IUUC-Gmo-038816	Gadus morhua	72.64	0.00e+00	1021.00
IUUC-Gga-040999	Gallus gallus	83.36	0.00e+00	1171.00
IUUC-Gac-041353	Gasterosteus aculeatus	73.87	0.00e+00	1050.00
IUUC-Ggo-044558	Gorilla gorilla	87.38	0.00e+00	1209.00
IUUC-Hsa-046208	Homo sapiens	87.38	0.00e+00	1209.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	84.70	0.00e+00	1136.00
IUUC-Loc-052827	Lepisosteus oculatus	75.91	0.00e+00	1098.00
IUUC-Laf-054009	Loxodonta africana	83.63	0.00e+00	1161.00
IUUC-Mcc-055054	Macaca mulatta	87.38	0.00e+00	1208.00
IUUC-Meu-056269	Macropus eugenii	82.18	0.00e+00	735.00
IUUC-Mga-060106	Meleagris gallopavo	84.59	0.00e+00	1170.00
IUUC-Mmr-061118	Microcebus murinus	86.80	0.00e+00	1199.00
IUUC-Mdo-062380	Monodelphis domestica	83.78	0.00e+00	1190.00
IUUC-Mmu-063135	Mus musculus	88.03	0.00e+00	1232.00
IUUC-Mpu-066135	Mustela putorius furo	86.93	0.00e+00	1221.00
IUUC-Nle-069465	Nomascus leucogenys	80.05	0.00e+00	1081.00
IUUC-Ont-071945	Oreochromis niloticus	74.59	0.00e+00	1040.00
IUUC-Oan-073384	Ornithorhynchus anatinus	82.47	0.00e+00	1134.00
IUUC-Ola-087499	Oryzias latipes	73.35	0.00e+00	1037.00
IUUC-Oga-088444	Otolemur garnettii	87.35	0.00e+00	1202.00
IUUC-Ptr-090507	Pan troglodytes	88.58	0.00e+00	1216.00
IUUC-Pan-092325	Papio anubis	86.52	0.00e+00	1191.00
IUUC-Psi-094021	Pelodiscus sinensis	83.47	0.00e+00	1163.00
IUUC-Pma-094372	Petromyzon marinus	50.00	0.00e+00	660.00
IUUC-Pfo-096732	Poecilia formosa	74.66	0.00e+00	1055.00
IUUC-Pab-098426	Pongo abelii	73.67	0.00e+00	963.00
IUUC-Pca-100295	Procavia capensis	86.63	0.00e+00	1217.00
IUUC-Rno-105332	Rattus norvegicus	87.35	0.00e+00	1169.00
IUUC-Sha-106529	Sarcophilus harrisii	87.57	0.00e+00	1196.00
IUUC-Ssc-116176	Sus scrofa	89.32	0.00e+00	1233.00
IUUC-Tgu-116917	Taeniopygia guttata	85.01	0.00e+00	1169.00
IUUC-Tru-118398	Takifugu rubripes	76.59	0.00e+00	968.00
IUUC-Tni-120819	Tetraodon nigroviridis	74.56	0.00e+00	1065.00
IUUC-Xtr-132747	Xenopus tropicalis	73.80	0.00e+00	1040.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence