iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067511

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AAPE02052700

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000000359.2	ENSMLUT00000000361.2	ENSMLUP00000000329.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-96	321.8	195	824

Active Site

Position(s)	Description	Evidence
204	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
760	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp............kepkgellkslqklfeelwkskkkav 68
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                  +p             ep g+l+ ++ ++++e+++++k+ v
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkI--------EPpdlaltepleihLEPPGPLTLAMSQFLSEMQETSKGIV 275
           5******************************7544444441........3356666666777789999********************* PP
   S: 69   sprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlks 152
           +p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk  +s+++++F+g+l+s
   Q: 276  TPKELFSQVCKKAVRFRGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKAVPSFVDRIFGGELTS 364
           ************************************************************9999999999******************* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke........................................................ 185
           +i+c ec++vs  +e+fldlslpv ++++ kk+                                                        
   Q: 365  TIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmenedkdseeekdndtyikerndipsgiskhlqkkakkqakkqaknq 453
           ****************************99999******************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  rrqqkiqgkvlhlndvcaldhlednecetemsvegevdiksdhisqeevinkeycvnqndlngqekmienvtdnqkftedvdvtsvsvd 542
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 543  ddlevlpssptdcpgslngacldaggggevdisrgfrnlhldaalhpddihleilngspapgttlyecvgqdpetafctlanrdassad 631
           ***************************************************************************************** PP
   S: 186  ..slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
             s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +kink+++f
   Q: 632  ecSIQHCLYQFTQNEKLRDANKLLCEVCTRRQCgapkanlkgekkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKINKHIKF 718
           *****************************888899999999999999999*********************..9999************ PP
   S: 256  pleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtev 317
           p+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++Ds+V++v
   Q: 719  PEILDLAPFCTAKCKNVAEestRVLYSLYGVVEHSGTMRSGHYTAYAKArmansrlsdlvlrgdvpqdfemesTKGQWFHISDSHVQAV 807
           ************9999988888999************************9999999999999999999999888999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 808  PTAKVLN---SQAYLLFYER 824
           *******...********98 PP

Organism

Myotis lucifugus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRIKGKI VPVDDSSESL EPVCRHIRKG LERSILKKAL VSVEWNICQD CKTDNKVKDT 60
SEEETEENPS VWLCLKCGHQ GCSRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAAGA AACGGATAAA GGGAAAAATT GTTCCAGTTG ATGATTCTTC TGAATCTTTA 60
GGTATATTTC ACCAATTGAA CCTTTAAAGT GATTTTATGT CTGTAAATGG ACATTTTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.23	1.00e-28	122.00
IUUC-Aml-001931	Ailuropoda melanoleuca	85.96	0.00e+00	1332.00
IUUC-Atr-003015	Amborella trichopoda	30.94	5.00e-35	143.00
IUUC-Apl-004145	Anas platyrhynchos	61.61	0.00e+00	893.00
IUUC-Aca-004314	Anolis carolinensis	58.14	0.00e+00	865.00
IUUC-Aly-006422	Arabidopsis lyrata	28.66	4.00e-29	123.00
IUUC-Ath-006732	Arabidopsis thaliana	30.23	2.00e-32	134.00
IUUC-Ame-011659	Astyanax mexicanus	46.67	3.00e-109	389.00
IUUC-Bta-013362	Bos taurus	86.34	0.00e+00	1333.00
IUUC-Bdi-014465	Brachypodium distachyon	31.12	8.00e-29	122.00
IUUC-Bol-015941	Brassica oleracea	30.00	4.00e-32	133.00
IUUC-Bra-016751	Brassica rapa	29.36	5.00e-30	127.00
IUUC-Cja-019177	Callithrix jacchus	85.97	0.00e+00	1364.00
IUUC-Cfa-020051	Canis familiaris	85.97	0.00e+00	1340.00
IUUC-Cpo-021886	Cavia porcellus	75.90	0.00e+00	1213.00
IUUC-Csa-024103	Chlorocebus sabaeus	86.22	0.00e+00	1374.00
IUUC-Cho-024315	Choloepus hoffmanni	70.14	1.00e-114	407.00
IUUC-Cin-025775	Ciona intestinalis	49.65	2.00e-40	157.00
IUUC-Csv-026075	Ciona savignyi	50.95	4.00e-59	222.00
IUUC-Cme-027348	Cyanidioschyzon merolae	39.19	3.00e-20	93.60
IUUC-Dre-028388	Danio rerio	46.73	0.00e+00	642.00
IUUC-Dno-029409	Dasypus novemcinctus	83.07	0.00e+00	1316.00
IUUC-Dor-030443	Dipodomys ordii	76.75	0.00e+00	637.00
IUUC-Ete-032807	Echinops telfairi	83.01	0.00e+00	670.00
IUUC-Eca-033479	Equus caballus	85.85	0.00e+00	1352.00
IUUC-Eeu-034835	Erinaceus europaeus	69.88	0.00e+00	769.00
IUUC-Fca-036320	Felis catus	86.82	0.00e+00	1385.00
IUUC-Fal-037029	Ficedula albicollis	60.17	0.00e+00	837.00
IUUC-Gmo-039480	Gadus morhua	51.72	6.00e-113	401.00
IUUC-Gga-040527	Gallus gallus	62.17	0.00e+00	888.00
IUUC-Gac-042343	Gasterosteus aculeatus	48.16	1.00e-112	400.00
IUUC-Gma-044402	Glycine max	28.94	1.00e-33	138.00
IUUC-Ggo-045598	Gorilla gorilla	86.22	0.00e+00	1369.00
IUUC-Hsa-046598	Homo sapiens	85.85	0.00e+00	1359.00
IUUC-Hvu-047146	Hordeum vulgare	28.83	7.00e-28	119.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	84.99	0.00e+00	1349.00
IUUC-Lch-050536	Latimeria chalumnae	55.53	2.00e-126	446.00
IUUC-Lpe-050703	Leersia perrieri	30.03	8.00e-29	122.00
IUUC-Laf-053732	Loxodonta africana	82.05	0.00e+00	1323.00
IUUC-Mcc-054661	Macaca mulatta	86.46	0.00e+00	1375.00
IUUC-Meu-055967	Macropus eugenii	71.75	1.00e-152	533.00
IUUC-Mtr-057945	Medicago truncatula	29.62	9.00e-34	139.00
IUUC-Mga-059551	Meleagris gallopavo	62.01	0.00e+00	897.00
IUUC-Mmr-061747	Microcebus murinus	86.49	0.00e+00	1338.00
IUUC-Mdo-062220	Monodelphis domestica	66.99	0.00e+00	1006.00
IUUC-Mmu-063582	Mus musculus	78.29	0.00e+00	1186.00
IUUC-Mac-064941	Musa acuminata	33.23	9.00e-37	148.00
IUUC-Mpu-066339	Mustela putorius furo	85.61	0.00e+00	1359.00
IUUC-Nle-069252	Nomascus leucogenys	86.58	0.00e+00	1377.00
IUUC-Opr-070969	Ochotona princeps	81.49	0.00e+00	1239.00
IUUC-Ont-071786	Oreochromis niloticus	49.53	6.00e-115	408.00
IUUC-Ocu-074704	Oryctolagus cuniculus	85.66	0.00e+00	1325.00
IUUC-Oba-075094	Oryza barthii	29.05	2.00e-29	125.00
IUUC-Obr-076743	Oryza brachyantha	31.58	6.00e-31	129.00
IUUC-Ogl-077739	Oryza glaberrima	29.05	1.00e-29	125.00
IUUC-Ogu-078851	Oryza glumaepatula	29.05	2.00e-29	125.00
IUUC-Oin-079402	Oryza indica	29.05	2.00e-29	125.00
IUUC-Olo-080431	Oryza longistaminata	29.05	2.00e-29	125.00
IUUC-Ome-081580	Oryza meridionalis	29.05	3.00e-29	124.00
IUUC-Oni-082644	Oryza nivara	29.05	2.00e-29	125.00
IUUC-Osa-085858	Oryza sativa	29.05	2.00e-29	125.00
IUUC-Ola-086795	Oryzias latipes	48.21	8.00e-110	391.00
IUUC-Oga-088713	Otolemur garnettii	85.13	0.00e+00	1341.00
IUUC-Oar-089887	Ovis aries	86.82	0.00e+00	1350.00
IUUC-Ptr-091670	Pan troglodytes	85.97	0.00e+00	1369.00
IUUC-Pan-092293	Papio anubis	86.46	0.00e+00	1375.00
IUUC-Psi-093101	Pelodiscus sinensis	63.29	0.00e+00	903.00
IUUC-Ppa-095622	Physcomitrella patens	31.78	8.00e-34	139.00
IUUC-Pfo-097202	Poecilia formosa	48.16	8.00e-116	411.00
IUUC-Pab-098773	Pongo abelii	85.49	0.00e+00	1061.00
IUUC-Pop-099136	Populus trichocarpa	30.41	7.00e-39	155.00
IUUC-Pca-101069	Procavia capensis	66.99	0.00e+00	814.00
IUUC-Ppe-101794	Prunus persica	30.99	4.00e-35	143.00
IUUC-Pva-103092	Pteropus vampyrus	80.27	0.00e+00	630.00
IUUC-Rno-105237	Rattus norvegicus	79.18	0.00e+00	1196.00
IUUC-Sha-106889	Sarcophilus harrisii	69.93	0.00e+00	1063.00
IUUC-Spo-108149	Schizosaccharomyces pombe	36.10	2.00e-22	101.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	26.42	4.00e-14	73.60
IUUC-Sit-110283	Setaria italica	31.21	3.00e-29	124.00
IUUC-Sly-111487	Solanum lycopersicum	30.59	6.00e-38	152.00
IUUC-Stu-112820	Solanum tuberosum	29.74	5.00e-38	153.00
IUUC-Sar-113530	Sorex araneus	79.95	0.00e+00	1250.00
IUUC-Sbi-113785	Sorghum bicolor	38.06	7.00e-25	109.00
IUUC-Ssc-116091	Sus scrofa	86.40	0.00e+00	1324.00
IUUC-Tgu-117478	Taeniopygia guttata	59.17	0.00e+00	857.00
IUUC-Tru-118640	Takifugu rubripes	51.97	8.00e-117	414.00
IUUC-Tsy-119042	Tarsius syrichta	73.55	0.00e+00	865.00
IUUC-Tca-121701	Theobroma cacao	29.55	6.00e-38	152.00
IUUC-Tae-125305	Triticum aestivum	29.45	2.00e-26	114.00
IUUC-Tur-126788	Triticum urartu	29.14	1.00e-26	115.00
IUUC-Tbe-127309	Tupaia belangeri	73.20	0.00e+00	1039.00
IUUC-Ttr-128271	Tursiops truncatus	86.34	0.00e+00	1358.00
IUUC-Vpa-130674	Vicugna pacos	85.97	0.00e+00	1248.00
IUUC-Xtr-131869	Xenopus tropicalis	51.93	0.00e+00	790.00
IUUC-Xma-134195	Xiphophorus maculatus	48.81	8.00e-116	411.00
IUUC-Zma-135157	Zea mays	31.27	3.00e-27	117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence