iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120910

UUCD1 version

UUC-TeN-01034

Ensembl Protein ID

ENSTNIP00000013938.1

UniProt Accession

H3D0A2; H3D0A2_TETNG

Protein Name

Apoptotic protease-activating factor 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000011007.1	ENSTNIT00000014133.1	ENSTNIP00000013938.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.90e-50	165.8	663	692
UBD/Beta-Prp	1.90e-86	290.2	966	1210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H d+v c+af +d +ll+++s D ++kvW+
   Q: 663  HDDEVLCCAFsPDdRLLATCSSDRKVKVWN 692
           9**********777***************9 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           ++++s+i++ +  ++ s ++ g ++gt++v ++ tgk+l++l gh+++v  ++fs+ g++l t+seD ti+vw  ++g+c  tl gh
   Q: 966  EEKSSRIRSTCLCRNPSAVVIGQENGTVQVLELPTGKVLATLLGHTKTVFWCQFSQCGETLFTSSEDTTIRVWRWRSGECK-TLLGH 1051
           5667788888888899****************************************************************6.6667* PP
   S: 94   edsvls...lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
            ++v+    ls+sps+ +l+s s d t+++wd+e+g++l+   + h+g++ + +v+pdg+ +++ s+Drt +lW  ++ ++++tl+g
   Q: 1052 REQVRHfslLSSSPSDTRLLSWSFDGTVKMWDTESGEKLQ-DMEAHQGAILSCHVSPDGCFFATTSADRTAKLWHCESWQCVHTLKG 1137
           *****966688888**************************.8889999**************************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgssDg 244
            h++ v+s  f+ +++++++g+++g ++lw+ + g+ ++++              +v++++fs+++++lvs++  g
   Q: 1138 -HQECVRSCRFSWDSRRVATGDDNGEIRLWSAKDGSLLKICSREGkdgmdslhgGWVTDLHFSRDNTLLVSTG--G 1210
           .********************************999988887666678888888*****************98..4 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

LEERARSCLL RFRHQLEQDI KPSYLMDHMV SDGVLSIDEE DRIRTLPTRR DQAVALLELL 60
LKKDNRAYIS FYNSLVKVAY NDLATLLFEA LPRSASDGCT PYGNRLITSF AVCPTVQTVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGAGGAAA GAGCAAGGAG CTGCCTGTTG CGCTTTCGTC ACCAATTGGA GCAGGACATC 60
AAGCCGTCCT ACCTGATGGA TCACATGGTC AGTGATGGTG TGCTCAGCAT AGATGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00114--CARD
SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0097190--P:apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	52.46	0.00e+00	1306.00
IUUC-Apl-004201	Anas platyrhynchos	52.34	0.00e+00	1310.00
IUUC-Aca-004638	Anolis carolinensis	52.30	0.00e+00	1321.00
IUUC-Ani-009285	Aspergillus nidulans	26.13	2.00e-60	228.00
IUUC-Ame-011062	Astyanax mexicanus	69.55	0.00e+00	1729.00
IUUC-Bta-012865	Bos taurus	52.99	0.00e+00	1327.00
IUUC-Cja-018815	Callithrix jacchus	48.83	0.00e+00	1161.00
IUUC-Cfa-020222	Canis familiaris	49.72	0.00e+00	1208.00
IUUC-Cpo-021524	Cavia porcellus	52.47	0.00e+00	1318.00
IUUC-Cre-022958	Chlamydomonas reinhardtii	20.31	1.00e-28	122.00
IUUC-Csa-023861	Chlorocebus sabaeus	52.96	0.00e+00	1329.00
IUUC-Cho-024484	Choloepus hoffmanni	43.87	2.00e-172	600.00
IUUC-Dre-028006	Danio rerio	66.14	0.00e+00	1575.00
IUUC-Dno-029591	Dasypus novemcinctus	53.77	0.00e+00	1353.00
IUUC-Dor-030237	Dipodomys ordii	41.02	3.00e-143	503.00
IUUC-Ete-032620	Echinops telfairi	50.40	0.00e+00	636.00
IUUC-Eca-033569	Equus caballus	52.67	0.00e+00	1315.00
IUUC-Eeu-035354	Erinaceus europaeus	50.92	2.00e-86	313.00
IUUC-Fca-036337	Felis catus	52.71	0.00e+00	1328.00
IUUC-Fal-037077	Ficedula albicollis	52.47	0.00e+00	1296.00
IUUC-Gmo-039687	Gadus morhua	63.72	0.00e+00	1202.00
IUUC-Gga-040299	Gallus gallus	51.70	0.00e+00	1304.00
IUUC-Gac-041762	Gasterosteus aculeatus	76.41	0.00e+00	1862.00
IUUC-Ggo-045563	Gorilla gorilla	53.28	0.00e+00	1340.00
IUUC-Hsa-046771	Homo sapiens	53.12	0.00e+00	1337.00
IUUC-Lch-050200	Latimeria chalumnae	56.37	0.00e+00	1428.00
IUUC-Loc-052090	Lepisosteus oculatus	64.41	0.00e+00	1574.00
IUUC-Laf-053861	Loxodonta africana	53.19	0.00e+00	1327.00
IUUC-Mcc-055543	Macaca mulatta	53.28	0.00e+00	1335.00
IUUC-Meu-056688	Macropus eugenii	54.18	0.00e+00	1320.00
IUUC-Mga-059243	Meleagris gallopavo	52.03	0.00e+00	1314.00
IUUC-Mmr-061134	Microcebus murinus	50.36	0.00e+00	1120.00
IUUC-Mdo-062913	Monodelphis domestica	53.77	0.00e+00	1316.00
IUUC-Mmu-063811	Mus musculus	53.88	0.00e+00	1340.00
IUUC-Mpu-066780	Mustela putorius furo	52.23	0.00e+00	1311.00
IUUC-Mlu-067276	Myotis lucifugus	53.44	0.00e+00	1327.00
IUUC-Nle-069129	Nomascus leucogenys	52.96	0.00e+00	1332.00
IUUC-Opr-071007	Ochotona princeps	41.69	2.00e-167	583.00
IUUC-Ont-071348	Oreochromis niloticus	81.27	0.00e+00	2032.00
IUUC-Oan-072717	Ornithorhynchus anatinus	54.06	0.00e+00	1374.00
IUUC-Ocu-074286	Oryctolagus cuniculus	53.44	0.00e+00	1114.00
IUUC-Ola-086895	Oryzias latipes	68.36	0.00e+00	1708.00
IUUC-Oga-088678	Otolemur garnettii	53.37	0.00e+00	1337.00
IUUC-Oar-089359	Ovis aries	53.12	0.00e+00	1330.00
IUUC-Ptr-091062	Pan troglodytes	53.12	0.00e+00	1337.00
IUUC-Pan-092528	Papio anubis	57.12	0.00e+00	871.00
IUUC-Psi-093430	Pelodiscus sinensis	54.31	0.00e+00	1343.00
IUUC-Pma-094690	Petromyzon marinus	36.73	1.00e-129	456.00
IUUC-Pfo-097204	Poecilia formosa	76.46	0.00e+00	1933.00
IUUC-Pab-097690	Pongo abelii	53.20	0.00e+00	1336.00
IUUC-Pca-100778	Procavia capensis	41.95	1.00e-179	624.00
IUUC-Pva-102870	Pteropus vampyrus	52.28	0.00e+00	1188.00
IUUC-Rno-104889	Rattus norvegicus	52.95	0.00e+00	1307.00
IUUC-Sha-107465	Sarcophilus harrisii	52.99	0.00e+00	1326.00
IUUC-Sar-113268	Sorex araneus	50.85	9.00e-107	381.00
IUUC-Ssc-115654	Sus scrofa	53.12	0.00e+00	1338.00
IUUC-Tgu-117302	Taeniopygia guttata	52.31	0.00e+00	1303.00
IUUC-Tru-118363	Takifugu rubripes	88.73	0.00e+00	2201.00
IUUC-Tsy-119007	Tarsius syrichta	52.71	0.00e+00	1304.00
IUUC-Tbe-127413	Tupaia belangeri	43.26	0.00e+00	735.00
IUUC-Ttr-129213	Tursiops truncatus	51.54	0.00e+00	1209.00
IUUC-Vpa-130146	Vicugna pacos	48.18	0.00e+00	865.00
IUUC-Xtr-132559	Xenopus tropicalis	49.47	0.00e+00	1220.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence