iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093685

Ensembl Protein ID

ENSPSIP00000017243.1

UniProt Accession

K7GAD2; K7GAD2_PELSI

Genbank Protein ID

ENSPSIP00000017243

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGCU01106777

Gene Name

LYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000015116.1	ENSPSIT00000017321.1	ENSPSIP00000017243.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.20e-16	57.9	70	125

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +ly+y++ ++d+L++kkG++++v+   e+ ++W+++++  ++k+G++P+n+v+k++
   Q: 70   IVVALYPYDGIHEDDLSFKKGEKMKVL---EELGEWWRAKSLSTKKEGFIPSNYVAKVN 125
           799************************...8999***********************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MGCIKSKRKE TLPGDGLDLK NQPVRKTERT IYVRDPTSNK QQRPVRQMHL LPGQRFSNEE 60
LIEAKEHGDI VVALYPYDGI HEDDLSFKKG EKMKVLEELG EWWRAKSLST KKEGFIPSNY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGATGTA TAAAATCAAA AAGGAAAGAG ACTCTGCCTG GAGATGGGCT AGATTTGAAG 60
AACCAACCAG TACGTAAAAC TGAACGAACT ATTTATGTGA GGGATCCAAC GTCCAATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001782--P:B cell homeostasis
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0097028--P:dendritic cell differentiation
GO:0030218--P:erythrocyte differentiation
GO:0002774--P:Fc receptor mediated inhibitory signaling pathway
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043407--P:negative regulation of MAP kinase activity
GO:0070667--P:negative regulation of mast cell proliferation
GO:0002762--P:negative regulation of myeloid leukocyte differentiation
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144--P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175--P:neuron projection development
GO:0002576--P:platelet degranulation
GO:0050861--P:positive regulation of B cell receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0070668--P:positive regulation of mast cell proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304--P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0046777--P:protein autophosphorylation
GO:0002902--P:regulation of B cell apoptotic process
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0050707--P:regulation of cytokine secretion
GO:0045646--P:regulation of erythrocyte differentiation
GO:0050727--P:regulation of inflammatory response
GO:0043304--P:regulation of mast cell degranulation
GO:0090025--P:regulation of monocyte chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0009725--P:response to hormone
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	88.20	0.00e+00	950.00
IUUC-Apl-004139	Anas platyrhynchos	91.73	0.00e+00	982.00
IUUC-Aca-004333	Anolis carolinensis	88.80	0.00e+00	948.00
IUUC-Ame-011257	Astyanax mexicanus	77.84	0.00e+00	836.00
IUUC-Bta-013257	Bos taurus	87.62	0.00e+00	944.00
IUUC-Cja-018827	Callithrix jacchus	87.81	0.00e+00	947.00
IUUC-Cfa-020816	Canis familiaris	88.20	0.00e+00	951.00
IUUC-Cpo-021423	Cavia porcellus	87.81	0.00e+00	944.00
IUUC-Csa-024244	Chlorocebus sabaeus	87.43	0.00e+00	939.00
IUUC-Dre-028518	Danio rerio	76.88	0.00e+00	817.00
IUUC-Dno-029322	Dasypus novemcinctus	88.20	0.00e+00	945.00
IUUC-Dor-030706	Dipodomys ordii	78.14	0.00e+00	818.00
IUUC-Eca-034193	Equus caballus	88.59	0.00e+00	954.00
IUUC-Fca-035937	Felis catus	70.35	0.00e+00	719.00
IUUC-Fal-037273	Ficedula albicollis	91.89	0.00e+00	983.00
IUUC-Gmo-039677	Gadus morhua	76.12	0.00e+00	736.00
IUUC-Gga-040417	Gallus gallus	88.01	0.00e+00	935.00
IUUC-Gac-042490	Gasterosteus aculeatus	70.41	0.00e+00	783.00
IUUC-Ggo-045096	Gorilla gorilla	87.43	0.00e+00	941.00
IUUC-Hsa-046214	Homo sapiens	87.43	0.00e+00	941.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	88.20	0.00e+00	949.00
IUUC-Lch-049991	Latimeria chalumnae	80.73	0.00e+00	854.00
IUUC-Loc-052309	Lepisosteus oculatus	79.42	0.00e+00	854.00
IUUC-Laf-053568	Loxodonta africana	87.81	0.00e+00	945.00
IUUC-Mcc-054849	Macaca mulatta	87.43	0.00e+00	939.00
IUUC-Meu-056170	Macropus eugenii	73.31	0.00e+00	747.00
IUUC-Mga-060194	Meleagris gallopavo	71.21	0.00e+00	688.00
IUUC-Mmr-061519	Microcebus murinus	87.04	0.00e+00	939.00
IUUC-Mdo-062090	Monodelphis domestica	76.98	0.00e+00	838.00
IUUC-Mmu-063760	Mus musculus	88.20	0.00e+00	947.00
IUUC-Mpu-065677	Mustela putorius furo	88.01	0.00e+00	949.00
IUUC-Mlu-067386	Myotis lucifugus	87.81	0.00e+00	943.00
IUUC-Nle-069742	Nomascus leucogenys	87.62	0.00e+00	942.00
IUUC-Opr-070705	Ochotona princeps	70.08	0.00e+00	746.00
IUUC-Ont-071537	Oreochromis niloticus	74.13	0.00e+00	797.00
IUUC-Oan-073193	Ornithorhynchus anatinus	87.48	0.00e+00	941.00
IUUC-Ocu-074501	Oryctolagus cuniculus	88.01	0.00e+00	946.00
IUUC-Ola-086726	Oryzias latipes	70.99	0.00e+00	782.00
IUUC-Oga-088069	Otolemur garnettii	86.90	0.00e+00	939.00
IUUC-Oar-090091	Ovis aries	87.81	0.00e+00	948.00
IUUC-Ptr-091409	Pan troglodytes	87.43	0.00e+00	941.00
IUUC-Pan-092268	Papio anubis	87.43	0.00e+00	939.00
IUUC-Pma-094311	Petromyzon marinus	68.45	0.00e+00	673.00
IUUC-Pfo-096217	Poecilia formosa	73.55	0.00e+00	803.00
IUUC-Pab-098601	Pongo abelii	87.43	0.00e+00	941.00
IUUC-Pva-102160	Pteropus vampyrus	77.22	0.00e+00	806.00
IUUC-Rno-105557	Rattus norvegicus	88.39	0.00e+00	950.00
IUUC-Sha-106643	Sarcophilus harrisii	86.32	0.00e+00	933.00
IUUC-Ssc-116317	Sus scrofa	82.31	0.00e+00	876.00
IUUC-Tgu-116865	Taeniopygia guttata	91.70	0.00e+00	980.00
IUUC-Tru-118284	Takifugu rubripes	72.06	0.00e+00	783.00
IUUC-Tsy-119440	Tarsius syrichta	83.56	0.00e+00	886.00
IUUC-Tni-120005	Tetraodon nigroviridis	70.27	0.00e+00	768.00
IUUC-Tbe-128144	Tupaia belangeri	70.31	0.00e+00	649.00
IUUC-Xtr-131907	Xenopus tropicalis	76.05	0.00e+00	795.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence