iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028829

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU929100

Gene Name

HERC4; herc4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000059936.5	ENSDART00000083883.5	ENSDARP00000078318.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.30e-103	345.9	728	1051

Active Site

Position(s)	Description	Evidence
1020	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l++kel +p++g+f+++e+++  ++  ++      e ++lF+++G+++g+a+++  +++l
   Q: 728  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLHPKYGMFRFHEESRLIWFACKTF-----EDIDLFHLIGVVCGLAIYNLTIVEL 809
           78999*********************************************9987766.....79*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+k  +ledl+e++p++ +sl++++++ e+d+ee+ ++l+f+++e+++g t+++eL+p+G +i+V+++N++e+v+++
   Q: 810  NFPLALYKKLLKKTPTLEDLKELMPDVGRSLQQLLDYTEDDLEET-FCLNFTITEDNFGATEVVELIPNGTDISVNKSNRQEFVNAY 895
           *************************************99999987.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++++++ q+ af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k t+ykg+y +d+p+i+ Fwev++e+  e++k+f
   Q: 896  VDYIFNKSVAPQFSAFYAGFHKVCGGKVLELFQPSELQAMVIGNTNYDWKELEKSTEYKGEYWADHPTIKIFWEVFHELPLEKKKQF 982
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++l     vi+  ++ ++ +P ++TCfn+L+LP+Y+sk++++ekLl Aie+++gF+l
   Q: 983  LLFLTGSDRIPILGMKSLA---LVIQPtAGGEQYFPVAHTCFNLLDLPKYTSKNTMQEKLLHAIEHNQGFNL 1051
           *******************...6666659999**************************************87 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE VLLEPRRCEF FEGKRVRDVG CGRRHTVFLL EDGTVYTCGC 60
NDLGQLGHEK ARKKPEQVVS LDAQNIVAVS CGEAHTLALN DKGQVFAWGL GSDGQLGLSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAAAATACA AAACTTGGGA TTTTCATAGA AAAAACAACG TCTCCCGCAG CTGTATCTCT 60
TCTTGCTGCA GGAACTCTGC GTGAGTCGTC ACATCCGGTC CCCAGAAATG CTCTAGAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:557513

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	74.62	0.00e+00	1541.00
IUUC-Apl-003295	Anas platyrhynchos	74.65	0.00e+00	1566.00
IUUC-Aca-004336	Anolis carolinensis	74.69	0.00e+00	1571.00
IUUC-Ame-010768	Astyanax mexicanus	80.78	0.00e+00	1736.00
IUUC-Bta-013279	Bos taurus	74.62	0.00e+00	1538.00
IUUC-Cja-019023	Callithrix jacchus	74.62	0.00e+00	1540.00
IUUC-Cfa-021074	Canis familiaris	74.72	0.00e+00	1542.00
IUUC-Cpo-021461	Cavia porcellus	73.35	0.00e+00	1505.00
IUUC-Csa-024261	Chlorocebus sabaeus	74.81	0.00e+00	1542.00
IUUC-Cin-025232	Ciona intestinalis	44.20	0.00e+00	843.00
IUUC-Dno-029445	Dasypus novemcinctus	71.46	0.00e+00	1213.00
IUUC-Dor-030158	Dipodomys ordii	77.68	0.00e+00	715.00
IUUC-Dme-032103	Drosophila melanogaster	44.85	0.00e+00	888.00
IUUC-Ete-033072	Echinops telfairi	67.68	0.00e+00	1352.00
IUUC-Eca-033317	Equus caballus	74.25	0.00e+00	1531.00
IUUC-Fca-035682	Felis catus	75.29	0.00e+00	1549.00
IUUC-Fal-036969	Ficedula albicollis	74.06	0.00e+00	1555.00
IUUC-Gmo-038671	Gadus morhua	77.33	0.00e+00	1664.00
IUUC-Gga-041174	Gallus gallus	74.25	0.00e+00	1562.00
IUUC-Gac-042600	Gasterosteus aculeatus	78.38	0.00e+00	1608.00
IUUC-Ggo-044589	Gorilla gorilla	74.72	0.00e+00	1561.00
IUUC-Hsa-046772	Homo sapiens	74.72	0.00e+00	1560.00
IUUC-Lch-050147	Latimeria chalumnae	73.22	0.00e+00	1283.00
IUUC-Loc-052684	Lepisosteus oculatus	78.00	0.00e+00	1642.00
IUUC-Laf-053844	Loxodonta africana	73.96	0.00e+00	1528.00
IUUC-Mcc-055531	Macaca mulatta	73.06	0.00e+00	1527.00
IUUC-Mga-060151	Meleagris gallopavo	72.07	0.00e+00	1261.00
IUUC-Mmr-060954	Microcebus murinus	74.72	0.00e+00	1541.00
IUUC-Mdo-062246	Monodelphis domestica	73.49	0.00e+00	1414.00
IUUC-Mmu-063369	Mus musculus	75.00	0.00e+00	1561.00
IUUC-Mpu-065936	Mustela putorius furo	73.81	0.00e+00	1404.00
IUUC-Mlu-067326	Myotis lucifugus	74.53	0.00e+00	1509.00
IUUC-Nle-069453	Nomascus leucogenys	75.29	0.00e+00	1547.00
IUUC-Ont-071720	Oreochromis niloticus	80.42	0.00e+00	1673.00
IUUC-Oan-073464	Ornithorhynchus anatinus	73.45	0.00e+00	1410.00
IUUC-Ocu-074207	Oryctolagus cuniculus	71.92	0.00e+00	1385.00
IUUC-Ola-086762	Oryzias latipes	78.79	0.00e+00	1612.00
IUUC-Oga-088435	Otolemur garnettii	75.00	0.00e+00	1546.00
IUUC-Oar-089233	Ovis aries	74.72	0.00e+00	1539.00
IUUC-Ptr-091368	Pan troglodytes	74.81	0.00e+00	1560.00
IUUC-Pan-092300	Papio anubis	74.81	0.00e+00	1542.00
IUUC-Psi-093406	Pelodiscus sinensis	74.48	0.00e+00	1565.00
IUUC-Pma-094113	Petromyzon marinus	66.47	0.00e+00	1041.00
IUUC-Ppa-095354	Physcomitrella patens	33.59	9.00e-138	484.00
IUUC-Pfo-097021	Poecilia formosa	77.76	0.00e+00	1692.00
IUUC-Pab-098327	Pongo abelii	74.72	0.00e+00	1558.00
IUUC-Pva-102909	Pteropus vampyrus	65.85	0.00e+00	1283.00
IUUC-Rno-105457	Rattus norvegicus	74.62	0.00e+00	1558.00
IUUC-Sha-106632	Sarcophilus harrisii	74.43	0.00e+00	1563.00
IUUC-Sar-113679	Sorex araneus	64.59	0.00e+00	826.00
IUUC-Tgu-116849	Taeniopygia guttata	70.19	0.00e+00	1456.00
IUUC-Tru-118206	Takifugu rubripes	77.04	0.00e+00	1572.00
IUUC-Tsy-119521	Tarsius syrichta	61.98	0.00e+00	1199.00
IUUC-Tni-120233	Tetraodon nigroviridis	77.04	0.00e+00	1573.00
IUUC-Vpa-130448	Vicugna pacos	74.43	0.00e+00	1535.00
IUUC-Xtr-132719	Xenopus tropicalis	65.38	0.00e+00	1267.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence