iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118328

Ensembl Protein ID

ENSTRUP00000039006.1

UniProt Accession

H2UPY5; H2UPY5_TAKRU

Protein Name

Histone-lysine N-methyltransferase

Gene Name

kmt2a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000015266.1	ENSTRUT00000039146.1	ENSTRUP00000039006.1
ENSTRUG00000015266.1	ENSTRUT00000039147.1	ENSTRUP00000039007.1
ENSTRUG00000015266.1	ENSTRUT00000039148.1	ENSTRUP00000039008.1
ENSTRUG00000015266.1	ENSTRUT00000039149.1	ENSTRUP00000039009.1
ENSTRUG00000015266.1	ENSTRUT00000039150.1	ENSTRUP00000039010.1
ENSTRUG00000015266.1	ENSTRUT00000039151.1	ENSTRUP00000039011.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.30e-18	66.8	1804	1863

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek...slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrs 53
           ++C +C +++ed++   ++veC +C++ +H++C kl+       ++lp+s +++C+kC++
   Q: 1804 NICVLCNKCYEDDEadgKMVECGRCHHRVHAKCEKLTddmyeLLSKLPESVAYTCTKCTE 1863
           79***********8999************************99***************86 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAHSCRWRFP ARPGGSSNSG TGRRAGRIRV TASLRSVPGA HPNAAGLGPG FDAALQVSSV 60
IESNLQKFRD VLGESSDSSS AEEEAFGGFR TVAEQKRIQS PSTTCSETPS PQEKKPRGRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCACA GCTGTCGGTG GCGGTTCCCT GCTCGGCCCG GAGGGAGCAG CAACTCCGGC 60
ACCGGGAGGA GAGCGGGCCG AATCAGGGTT ACTGCGTCTC TGCGGAGCGT CCCGGGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017956--AT_hook_DNA-bd_motif
IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00384--AT_hook
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0021782--P:glial cell development
GO:0048823--P:nucleate erythrocyte development
GO:0048339--P:paraxial mesoderm development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002274	Ailuropoda melanoleuca	45.59	0.00e+00	849.00
IUUC-Apl-003478	Anas platyrhynchos	45.26	0.00e+00	865.00
IUUC-Aca-005086	Anolis carolinensis	63.68	0.00e+00	1106.00
IUUC-Ath-006690	Arabidopsis thaliana	46.75	4.00e-36	147.00
IUUC-Ame-011195	Astyanax mexicanus	49.67	0.00e+00	1129.00
IUUC-Bta-012974	Bos taurus	43.99	0.00e+00	853.00
IUUC-Bol-016540	Brassica oleracea	46.10	2.00e-36	147.00
IUUC-Cja-019226	Callithrix jacchus	44.08	0.00e+00	869.00
IUUC-Cfa-021049	Canis familiaris	45.48	0.00e+00	863.00
IUUC-Cpo-021459	Cavia porcellus	43.95	0.00e+00	835.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	51.56	4.00e-38	154.00
IUUC-Csa-023434	Chlorocebus sabaeus	45.03	0.00e+00	870.00
IUUC-Cme-027224	Cyanidioschyzon merolae	36.71	1.00e-12	68.60
IUUC-Dre-028180	Danio rerio	52.18	0.00e+00	1309.00
IUUC-Dno-029068	Dasypus novemcinctus	58.58	0.00e+00	942.00
IUUC-Dor-030550	Dipodomys ordii	66.42	1.00e-163	572.00
IUUC-Ete-032834	Echinops telfairi	72.79	0.00e+00	696.00
IUUC-Eca-033615	Equus caballus	66.75	0.00e+00	1070.00
IUUC-Eeu-035136	Erinaceus europaeus	58.11	0.00e+00	698.00
IUUC-Fal-037256	Ficedula albicollis	67.04	0.00e+00	1124.00
IUUC-Gmo-038641	Gadus morhua	62.88	0.00e+00	2955.00
IUUC-Gga-040828	Gallus gallus	67.42	0.00e+00	1100.00
IUUC-Gac-041452	Gasterosteus aculeatus	74.60	0.00e+00	4565.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	62.67	0.00e+00	1006.00
IUUC-Lch-049704	Latimeria chalumnae	65.02	0.00e+00	1081.00
IUUC-Loc-052181	Lepisosteus oculatus	72.60	0.00e+00	1219.00
IUUC-Meu-056485	Macropus eugenii	44.60	0.00e+00	835.00
IUUC-Mtr-058327	Medicago truncatula	40.08	2.00e-37	151.00
IUUC-Mga-059943	Meleagris gallopavo	68.57	0.00e+00	1092.00
IUUC-Mmr-061178	Microcebus murinus	45.59	0.00e+00	870.00
IUUC-Mdo-063031	Monodelphis domestica	44.54	0.00e+00	842.00
IUUC-Opr-071043	Ochotona princeps	63.18	0.00e+00	970.00
IUUC-Ont-072556	Oreochromis niloticus	71.82	0.00e+00	2038.00
IUUC-Oan-073324	Ornithorhynchus anatinus	65.63	0.00e+00	1017.00
IUUC-Ocu-074190	Oryctolagus cuniculus	66.46	0.00e+00	1079.00
IUUC-Oba-075647	Oryza barthii	50.33	2.00e-38	154.00
IUUC-Olo-080577	Oryza longistaminata	47.06	8.00e-35	142.00
IUUC-Ome-081214	Oryza meridionalis	50.33	2.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	50.33	2.00e-38	154.00
IUUC-Opu-083842	Oryza punctata	50.33	2.00e-38	154.00
IUUC-Oru-084361	Oryza rufipogon	50.33	2.00e-38	154.00
IUUC-Ola-087176	Oryzias latipes	72.18	0.00e+00	1637.00
IUUC-Oar-090152	Ovis aries	44.50	0.00e+00	858.00
IUUC-Psi-094059	Pelodiscus sinensis	45.00	0.00e+00	890.00
IUUC-Pma-094258	Petromyzon marinus	51.42	1.00e-161	562.00
IUUC-Pfo-096536	Poecilia formosa	70.64	0.00e+00	4228.00
IUUC-Pca-100358	Procavia capensis	61.97	0.00e+00	926.00
IUUC-Pva-102522	Pteropus vampyrus	66.59	1.00e-177	619.00
IUUC-Sha-107174	Sarcophilus harrisii	65.61	0.00e+00	1112.00
IUUC-Smo-109164	Selaginella moellendorffii	50.65	3.00e-40	160.00
IUUC-Sly-111176	Solanum lycopersicum	46.41	2.00e-34	140.00
IUUC-Tgu-117047	Taeniopygia guttata	67.21	0.00e+00	1125.00
IUUC-Tsy-118953	Tarsius syrichta	69.18	8.00e-129	456.00
IUUC-Tni-120837	Tetraodon nigroviridis	88.88	0.00e+00	4313.00
IUUC-Tbe-127950	Tupaia belangeri	63.74	2.00e-180	628.00
IUUC-Ttr-128643	Tursiops truncatus	44.40	0.00e+00	842.00
IUUC-Vpa-130660	Vicugna pacos	66.07	0.00e+00	634.00
IUUC-Xtr-132869	Xenopus tropicalis	57.99	0.00e+00	1020.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence