iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049692

Ensembl Protein ID

ENSLACP00000021144.1

UniProt Accession

H3BGX3; H3BGX3_LATCH

Genbank Protein ID

ENSLACP00000021144

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01007138

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000018575.1	ENSLACT00000021284.1	ENSLACP00000021144.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-59	201.7	141	628

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +Gl+N+gNtC++ +v+Q+L+++pe+r+l+ +     +  e+++   +++++ +++++l++lf+ +  s++k v+p++ l+ lk++ ++ 
   Q: 141  VGLRNVGNTCWFSAVIQSLFHLPEFRRLVISyalpqSILESCRSH-SEKRNIAFMQELRTLFALMIGSNHKFVDPSAALELLKDAFRS- 227
           6******************************98776555555544.579999*******************************99998. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           ++ +qqD++Ef++ lld le++++                     + +++++k ++++++lF g++  + +    +++ s  e+f +++
   Q: 228  TEAQQQDVSEFTHKLLDWLEDAFQ------------------IAANVNHPTSKLENPMVQLFYGTFLAEGIH--DGKTFSNVETFGQYP 296
           79*********************2..................233556799999*************98887..45666889******* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  +   e+e+   +++++   + ++ +++++ klP+vL+++L+Rf+f+++ +++eki+kk+efp+ + l+
   Q: 297  LQVNGYN-----NLNECLEGAMVDGEIES---LHSDQ---SIRSGQEHWFAKLPPVLTFELSRFEFNQSLGRPEKIHKKLEFPELIYLD 374
           *******.....9*****99999999985...55555...556789******************************************* PP
   S: 263  pfcts.................................................................................pee 270
           +++++                                                                                 +  
   Q: 375  RYLHKnkeliqakreevkklkeqmtvlhqklerymsygsgpshfpladmlqyvlefastkpscvpptqdvqmsspsctpestsqsvT-- 461
           *****7788777777777777777777777777777777777777777777777777777777776666666666666655555550.. PP
   S: 271  kqke..................................................................................... 274
              +                                                                                     
   Q: 462  ---Qasvsdsdtsespesvaaspvsppsqrtpvhkpftqsrppvempthpaprfiteeefrfiesclqrwrsevehdvqernaplppyt 547
           ...05555555555556666666666666666666666666666666666667777777777777777777777777777777777777 PP
   S: 275  .............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                        k+ Y+L+av+vH+G+++ GHY+ay+++++++ Wl+++D  Vte+++ee ++++      ++aY+l+Y 
   Q: 548  gaerflrcrkeisKVPYRLHAVLVHEGQANAGHYWAYIYDHTRRmWLKYNDIAVTESSWEELERDSYgglknASAYCLMYI 628
           7777777777777***************************88889*******************8879************6 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

SVLINQLREI TGTQNIQLLQ EALKVSNQLF MKIPLLFEEH YLGNAETSFV FEKALNEDNK 60
MGFPLIKDVI DLTRDDKDDL QTAIALSLRE SQKAQTEERD LNRTLEANTV ESNPRTKRKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGTGCTAA TTAACCAGCT GAGAGAAATA ACGGGGACCC AGAATATCCA ACTGCTGCAG 60
GAAGCACTTA AGGTTAGTAA TCAACTCTTC ATGAAAATTC CCTTGTTGTA AGAGGAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	66.89	0.00e+00	1419.00
IUUC-Apl-004010	Anas platyrhynchos	63.81	0.00e+00	1355.00
IUUC-Acl-008164	Aspergillus clavatus	34.86	1.00e-11	65.90
IUUC-Afu-008871	Aspergillus fumigatus	35.78	3.00e-11	64.70
IUUC-Ani-009503	Aspergillus nidulans	36.70	2.00e-11	64.70
IUUC-Ang-009577	Aspergillus niger	41.03	5.00e-11	63.90
IUUC-Bta-013377	Bos taurus	64.69	0.00e+00	1397.00
IUUC-Cja-019977	Callithrix jacchus	66.92	0.00e+00	1411.00
IUUC-Cpo-021817	Cavia porcellus	65.88	0.00e+00	1390.00
IUUC-Cho-024717	Choloepus hoffmanni	58.28	0.00e+00	868.00
IUUC-Csv-025911	Ciona savignyi	33.96	1.00e-134	474.00
IUUC-Dre-028105	Danio rerio	61.52	0.00e+00	780.00
IUUC-Dno-029559	Dasypus novemcinctus	64.52	0.00e+00	1101.00
IUUC-Dor-030955	Dipodomys ordii	64.39	0.00e+00	1343.00
IUUC-Ete-032828	Echinops telfairi	59.90	0.00e+00	852.00
IUUC-Eca-034300	Equus caballus	66.29	0.00e+00	1377.00
IUUC-Eeu-034458	Erinaceus europaeus	64.71	0.00e+00	1222.00
IUUC-Fca-035753	Felis catus	66.85	0.00e+00	1429.00
IUUC-Gmo-039593	Gadus morhua	54.83	0.00e+00	1108.00
IUUC-Gga-040878	Gallus gallus	59.53	0.00e+00	1214.00
IUUC-Gac-041867	Gasterosteus aculeatus	58.09	0.00e+00	1192.00
IUUC-Ggo-045384	Gorilla gorilla	66.92	0.00e+00	1415.00
IUUC-Hsa-046277	Homo sapiens	66.98	0.00e+00	1420.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	60.17	0.00e+00	806.00
IUUC-Kpa-049349	Komagataella pastoris	36.23	3.00e-09	58.20
IUUC-Laf-053808	Loxodonta africana	62.06	0.00e+00	1288.00
IUUC-Meu-056416	Macropus eugenii	57.92	0.00e+00	1149.00
IUUC-Mga-060011	Meleagris gallopavo	61.74	0.00e+00	1283.00
IUUC-Mmr-060720	Microcebus murinus	64.66	0.00e+00	1338.00
IUUC-Mdo-061955	Monodelphis domestica	61.44	0.00e+00	1271.00
IUUC-Mmu-063870	Mus musculus	63.44	0.00e+00	1325.00
IUUC-Mlu-067487	Myotis lucifugus	63.64	0.00e+00	1331.00
IUUC-Nle-070044	Nomascus leucogenys	66.60	0.00e+00	1410.00
IUUC-Opr-070888	Ochotona princeps	77.62	2.00e-129	457.00
IUUC-Ocu-074523	Oryctolagus cuniculus	64.72	0.00e+00	1362.00
IUUC-Ola-086393	Oryzias latipes	58.09	0.00e+00	1170.00
IUUC-Oga-088618	Otolemur garnettii	66.79	0.00e+00	1399.00
IUUC-Ptr-091630	Pan troglodytes	67.87	0.00e+00	1124.00
IUUC-Psi-093422	Pelodiscus sinensis	60.04	0.00e+00	1288.00
IUUC-Pma-094250	Petromyzon marinus	49.43	4.00e-71	261.00
IUUC-Pno-095093	Phaeosphaeria nodorum	41.38	6.00e-13	69.70
IUUC-Pab-098337	Pongo abelii	66.60	0.00e+00	1409.00
IUUC-Pca-100901	Procavia capensis	58.12	0.00e+00	1174.00
IUUC-Pva-102226	Pteropus vampyrus	63.58	0.00e+00	1263.00
IUUC-Rno-105735	Rattus norvegicus	61.73	0.00e+00	1340.00
IUUC-Sha-107489	Sarcophilus harrisii	68.23	0.00e+00	1440.00
IUUC-Sja-107936	Schizosaccharomyces japonicus	42.50	7.00e-12	66.60
IUUC-Ssl-108532	Sclerotinia sclerotiorum	48.89	2.00e-09	58.50
IUUC-Tgu-116609	Taeniopygia guttata	62.23	0.00e+00	1263.00
IUUC-Tru-117807	Takifugu rubripes	57.88	0.00e+00	1168.00
IUUC-Tni-119983	Tetraodon nigroviridis	58.34	0.00e+00	1198.00
IUUC-Ttr-128887	Tursiops truncatus	61.90	0.00e+00	1270.00
IUUC-Vda-129742	Verticillium dahliae	24.70	1.00e-11	65.90
IUUC-Vpa-130614	Vicugna pacos	66.00	0.00e+00	1086.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence