iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067473

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02041033

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000008847.2	ENSMLUT00000008919.2	ENSMLUP00000008127.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	2.40e-128	429.6	1010	1539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 66   LktynreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvves 152
           L    ++W+ freql++ +++f      y+ +           +++w+++i+ed +krll+l+ +l++ +R+++++++r+l++++++
   Q: 1010 LGPKPTFWPLFREQLCRRTCLF------YTIR-----------AQAWSRDIAED-RKRLLQLCPRLNKVLRHEQNFADRFLPDDEAA 1078
           5555689***************......9999...........***********.******************************** PP
   S: 153  lveLslnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhles 238
                   +a++k+++Ea++++ +q+++ ++++  ++  + + +Yl+++e++ n+ +++a+++++++++++Ll++ve+   +     
   Q: 1079 --------RALGKTCWEALVSPLVQNITCPDAEGASSLgWLLGQYLEQRESSRNPLSRAASFASRVRRLCHLLVHVEPPPGP----- 1152
           ........9*************************************************************************..... PP
   S: 239  llaelvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnnda 323
             ++ +++   +++++ ++ +   s vl+  +l+++++++ s+++eq++++l+a++++ d   +V+r++ l+++lq++ se+F+++a
   Q: 1153 --SPEPSTQPPSRNSKGQDRSPGPSPVLPssSLRNMTQCWLSVVQEQVSRFLAAAWRAPD---FVPRYCALYEHLQRAGSELFGPRA 1234
           ..***************************99*****************************...************************ PP
   S: 324  kFlkaldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLls 406
           +F+ al+++f+ +++++s+l+a++++E++Ar+iDq++++  ++g+ +++++ ql+++l+ ++++s++++   Fe++Y++++a+RLls
   Q: 1235 AFTLALHSGFSGALLQQSFLTATHMSEQFARHIDQQIQGClVGGTPGADMLGQLQRHLEPIMVLSGLELattFEHFYQHYMADRLLS 1321
           *************************************************************************************** PP
   S: 407  gksasseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk........................................ 452
               ss++E++v+e++    g +f+++L ++M+q+l++Se+l+ qF+                                        
   Q: 1322 --LGSSWLEGAVLEQI----GSCFPHRLpQQMLQSLSASERLQCQFHlfqlqqldrllleqedeeeqgleeeevrareesgrtgeee 1402
           ..**************....******************************************************************* PP
   S: 453  .....eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY......lekhsgRkLqWqhtlgraelka 524
                + ke   e++++++s+lvLs+++Wp++  +    ++ +LP+ l++++++f++fY        ++++R+LqW++ lgrael++
   Q: 1403 eeeaeSGKELFLEDPGPTVSILVLSPRCWPVSplCYLyhPRKCLPTGLCDALDRFSSFYsqsqnhPVRGPHRRLQWTW-LGRAELQF 1488
           999888889999********************9866567********************765544446689*******.******** PP
   S: 525  elkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk 579
               g ++l+Vst+Qm++LL fn++e+vsve+l k ++l +++L ++l +L+s +
   Q: 1489 ----GDQTLHVSTVQMWLLLNFNQTEEVSVETLLKNSDLTPQLLLQALLPLTSEN 1539
           ....************************************************976 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

RMVGERRTGD LMVPLGPRLQ AYPEELIRQR PGHDGRPEYL IRWSVLKCGE VGRVDVEEGK 60
AEHILMWLSA PEVYANCPRL LGEWALAKGP QREPAGGSGS FPRDPGGLDD VAMGEMEADV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATGGTGG GGGAACGGCG CACTGGGGAC CTCATGGTGC CCTTGGGGCC TCGGCTGCAG 60
GCATATCCCG AAGAACTTAT TCGACAGCGT CCTGGGCACG ACGGACGTCC TGAATACCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR011987--ATPase_V1-cplx_hsu_C
IPR021097--CPH_domain
IPR031222--CUL9
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0000226--P:microtubule cytoskeleton organization
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003458	Anas platyrhynchos	52.99	3.00e-95	344.00
IUUC-Aca-004815	Anolis carolinensis	60.50	0.00e+00	799.00
IUUC-Cpo-022473	Cavia porcellus	78.67	0.00e+00	1380.00
IUUC-Cho-024879	Choloepus hoffmanni	76.98	2.00e-174	607.00
IUUC-Cin-025402	Ciona intestinalis	34.92	1.00e-102	368.00
IUUC-Dno-028904	Dasypus novemcinctus	89.17	0.00e+00	1172.00
IUUC-Ete-032516	Echinops telfairi	74.45	0.00e+00	738.00
IUUC-Eeu-035166	Erinaceus europaeus	91.62	0.00e+00	803.00
IUUC-Fal-036672	Ficedula albicollis	59.31	0.00e+00	757.00
IUUC-Gga-040154	Gallus gallus	49.36	6.00e-98	353.00
IUUC-Lch-049956	Latimeria chalumnae	49.32	0.00e+00	879.00
IUUC-Loc-052706	Lepisosteus oculatus	58.50	0.00e+00	825.00
IUUC-Laf-054297	Loxodonta africana	82.67	0.00e+00	1915.00
IUUC-Meu-056198	Macropus eugenii	61.61	0.00e+00	1480.00
IUUC-Mga-059683	Meleagris gallopavo	50.68	3.00e-94	338.00
IUUC-Mdo-062018	Monodelphis domestica	67.18	0.00e+00	1602.00
IUUC-Nle-069292	Nomascus leucogenys	89.47	0.00e+00	1150.00
IUUC-Pma-094192	Petromyzon marinus	45.99	0.00e+00	790.00
IUUC-Pfo-096773	Poecilia formosa	46.75	1.00e-138	488.00
IUUC-Pca-100539	Procavia capensis	77.38	0.00e+00	960.00
IUUC-Sha-106896	Sarcophilus harrisii	74.94	7.00e-175	608.00
IUUC-Sar-113132	Sorex araneus	82.64	0.00e+00	691.00
IUUC-Tgu-116915	Taeniopygia guttata	62.12	1.00e-136	479.00
IUUC-Tru-118013	Takifugu rubripes	58.12	0.00e+00	743.00
IUUC-Tni-120062	Tetraodon nigroviridis	55.59	0.00e+00	768.00
IUUC-Ttr-128780	Tursiops truncatus	85.86	0.00e+00	1231.00
IUUC-Vpa-130086	Vicugna pacos	80.40	0.00e+00	629.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence