iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065868

Ensembl Protein ID

ENSMPUP00000016608.1

UniProt Accession

M3YZ48; M3YZ48_MUSPF

Genbank Protein ID

ENSMPUP00000016608

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01066299

Gene Name

USP15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000016712.1	ENSMPUT00000016855.1	ENSMPUP00000016608.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.50e-118	394.6	289	953
ULD/UDP/UBQ/UBQ_Other	3.00e-10	39.8	147	217

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS++QcLsn+p+l+e++l+ k++e+ln +np ++ ge++ks+++l++++w++k ++v+pr+++++++++a++fsgy+
   Q: 289  CGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNdKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQ 377
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ ++kp+ +++++d   ++d+     a+e++ k+n+s+i+d+F+g +ks+++c+ec+++s++++pf++l
   Q: 378  QQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDAD--GRPDKivaeeAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYL 464
           ******************************9999..5555566777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p+k+e+ +e                                                                            
   Q: 465  TLPLPMKKERTLEvylvrmdpltkpmqykvvvpkignildlctalsalsgvpadkmivtdiynhrfhrifamdenlssimerddiyvfe 553
           *********9999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 554  ininrtedtehviipvclrekfrhssythhtgsslfgqpflmavprnntedklynllllrmcryvkisteteetegslhcckdqningn 642
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 643  gpngiheegspsemetdepddessqdqelpsenensqsedsvggdndsenglcteeickgqitghkkrlftfqfnnlgntdinyikddt 731
           ***************************************************************************************** PP
   S: 186  .......................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                  +l+dc+e ft++e+l  e+ +yc++ck++q+a+k
   Q: 732  rhirfderqlrldersflaldwdpdlkkryfdenaaedfekhesveykppkkpfvKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATK 820
           ***************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.W 306
           kl+l++lP+vL++hLkRfs+s+  ++r k+++ v+fp++ Ld+s+f+++p+ +   +++Y+Liav +H+G++++GHY+a++kn++++ W
   Q: 821  KLDLWSLPPVLVVHLKRFSYSR--YMRDKLDTLVDFPINdLDMSEFLINPNAG---PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGkW 904
           ******************9977..6999*********************9988...8**************************65555* PP
   S: 307  llfdDskVtevkeeevleetg.................staYvlfYkrr 338
           ++fdDs+V++ +e++++ ++                  + aYvlfY+r+
   Q: 905  YYFDDSSVSTASEDQIVISQPkhpeitysddtscsqqsKAAYVLFYQRQ 953
           ***************99966699************************96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
           + t++++++dt+ ++ ++i+k ++ip + + rL++k      ++L ++d t++d gl++g+++++++k+++
   Q: 147  VVTRRFSKADTIDTIEKEIRKIFNIPdEKETRLWNKymsntFEPLnKPDSTIQDAGLYQGQVLVIEQKNED 217
           77899*********************999*****998875544569*********************9986 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAEGGAADLD IQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 60
YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG GCGGAGCGGC AGATCTGGAC ATCCAGCGGT CTGACATCGC GACGCTGCTC 60
AAAACCTCGC TCCGGAAAGG AGACACCTGG TGAGAGAAAG AGCTTGAGAT GGTCGCGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR013792--RNA3'P_cycl/enolpyr_Trfase_a/b
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030509--P:BMP signaling pathway
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0060389--P:pathway-restricted SMAD protein phosphorylation
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	38.59	6.00e-116	411.00
IUUC-Aml-001852	Ailuropoda melanoleuca	97.60	0.00e+00	1893.00
IUUC-Apl-003249	Anas platyrhynchos	92.60	0.00e+00	1704.00
IUUC-Aca-004261	Anolis carolinensis	91.26	0.00e+00	1719.00
IUUC-Aly-005644	Arabidopsis lyrata	35.34	1.00e-135	477.00
IUUC-Ath-006782	Arabidopsis thaliana	35.04	5.00e-135	475.00
IUUC-Acl-008284	Aspergillus clavatus	35.27	2.00e-55	211.00
IUUC-Ani-009479	Aspergillus nidulans	42.81	1.00e-51	199.00
IUUC-Ame-010757	Astyanax mexicanus	78.09	0.00e+00	1249.00
IUUC-Bgr-012277	Blumeria graminis	43.11	1.00e-63	239.00
IUUC-Bta-013128	Bos taurus	93.71	0.00e+00	1848.00
IUUC-Bci-013993	Botrytis cinerea	43.49	2.00e-64	241.00
IUUC-Bol-015570	Brassica oleracea	37.11	2.00e-150	526.00
IUUC-Bra-017029	Brassica rapa	36.73	3.00e-138	486.00
IUUC-Cja-019222	Callithrix jacchus	96.80	0.00e+00	1882.00
IUUC-Cfa-020035	Canis familiaris	97.60	0.00e+00	1892.00
IUUC-Cpo-022071	Cavia porcellus	98.59	0.00e+00	1806.00
IUUC-Csa-023882	Chlorocebus sabaeus	97.00	0.00e+00	1887.00
IUUC-Csv-026109	Ciona savignyi	43.26	0.00e+00	693.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	36.41	2.00e-61	231.00
IUUC-Cme-027338	Cyanidioschyzon merolae	56.36	4.00e-68	253.00
IUUC-Dno-029025	Dasypus novemcinctus	90.66	0.00e+00	1759.00
IUUC-Dor-030956	Dipodomys ordii	87.88	0.00e+00	1610.00
IUUC-Dse-031432	Dothistroma septosporum	40.79	2.00e-58	221.00
IUUC-Eca-034340	Equus caballus	97.12	0.00e+00	1829.00
IUUC-Eeu-034488	Erinaceus europaeus	88.83	0.00e+00	1262.00
IUUC-Fca-035552	Felis catus	94.41	0.00e+00	1850.00
IUUC-Fal-036618	Ficedula albicollis	92.50	0.00e+00	1697.00
IUUC-Ggr-039740	Gaeumannomyces graminis	43.59	7.00e-62	233.00
IUUC-Gga-041146	Gallus gallus	91.33	0.00e+00	1739.00
IUUC-Gac-041679	Gasterosteus aculeatus	76.19	0.00e+00	1456.00
IUUC-Gma-042669	Glycine max	39.58	1.00e-115	410.00
IUUC-Ggo-045002	Gorilla gorilla	96.81	0.00e+00	1821.00
IUUC-Hsa-046052	Homo sapiens	96.90	0.00e+00	1885.00
IUUC-Hvu-047108	Hordeum vulgare	39.21	3.00e-120	425.00
IUUC-Itr-048306	Ictidomys tridecemlineatus	93.82	0.00e+00	1845.00
IUUC-Lch-050107	Latimeria chalumnae	84.45	0.00e+00	1715.00
IUUC-Loc-052105	Lepisosteus oculatus	82.09	0.00e+00	1500.00
IUUC-Lma-052981	Leptosphaeria maculans	36.48	2.00e-65	245.00
IUUC-Laf-053645	Loxodonta africana	96.51	0.00e+00	1875.00
IUUC-Mcc-055586	Macaca mulatta	96.90	0.00e+00	1885.00
IUUC-Meu-056764	Macropus eugenii	86.86	0.00e+00	989.00
IUUC-Mga-060162	Meleagris gallopavo	91.63	0.00e+00	1743.00
IUUC-Mmr-061105	Microcebus murinus	97.00	0.00e+00	1882.00
IUUC-Mdo-062107	Monodelphis domestica	94.92	0.00e+00	1822.00
IUUC-Mmu-063662	Mus musculus	95.40	0.00e+00	1860.00
IUUC-Mlu-068000	Myotis lucifugus	90.09	0.00e+00	1666.00
IUUC-Nle-069874	Nomascus leucogenys	96.80	0.00e+00	1860.00
IUUC-Opr-071212	Ochotona princeps	91.14	0.00e+00	1761.00
IUUC-Ont-071834	Oreochromis niloticus	78.14	0.00e+00	1448.00
IUUC-Ocu-074573	Oryctolagus cuniculus	96.90	0.00e+00	1883.00
IUUC-Oga-089022	Otolemur garnettii	93.11	0.00e+00	1836.00
IUUC-Oar-089767	Ovis aries	96.60	0.00e+00	1877.00
IUUC-Ptr-091319	Pan troglodytes	94.21	0.00e+00	1855.00
IUUC-Pan-091968	Papio anubis	97.00	0.00e+00	1887.00
IUUC-Psi-093849	Pelodiscus sinensis	91.26	0.00e+00	1696.00
IUUC-Pma-094533	Petromyzon marinus	58.85	0.00e+00	1104.00
IUUC-Pno-094890	Phaeosphaeria nodorum	36.12	1.00e-59	226.00
IUUC-Pfo-097110	Poecilia formosa	76.88	0.00e+00	1446.00
IUUC-Pab-098664	Pongo abelii	97.00	0.00e+00	1887.00
IUUC-Pca-100359	Procavia capensis	80.70	0.00e+00	1332.00
IUUC-Pva-102394	Pteropus vampyrus	95.20	0.00e+00	1839.00
IUUC-Pgr-103546	Puccinia graminis	30.08	2.00e-68	254.00
IUUC-Pte-104102	Pyrenophora teres	35.50	6.00e-57	217.00
IUUC-Pyt-104812	Pyrenophora triticirepentis	39.43	3.00e-56	214.00
IUUC-Rno-105383	Rattus norvegicus	93.11	0.00e+00	1839.00
IUUC-Sce-106170	Saccharomyces cerevisiae	36.97	2.00e-60	228.00
IUUC-Sha-107393	Sarcophilus harrisii	95.01	0.00e+00	1829.00
IUUC-Sja-107752	Schizosaccharomyces japonicus	34.48	1.00e-81	298.00
IUUC-Ssl-108461	Sclerotinia sclerotiorum	30.56	1.00e-13	71.60
IUUC-Sly-111726	Solanum lycopersicum	39.85	5.00e-93	335.00
IUUC-Sar-113498	Sorex araneus	96.40	0.00e+00	1873.00
IUUC-Sre-115130	Sporisorium reilianum	33.08	3.00e-88	320.00
IUUC-Ssc-115285	Sus scrofa	97.11	0.00e+00	1884.00
IUUC-Tgu-116529	Taeniopygia guttata	92.02	0.00e+00	1754.00
IUUC-Tru-118298	Takifugu rubripes	77.31	0.00e+00	1456.00
IUUC-Tsy-119117	Tarsius syrichta	86.78	0.00e+00	1144.00
IUUC-Tni-120093	Tetraodon nigroviridis	74.24	0.00e+00	1390.00
IUUC-Tre-121888	Trichoderma reesei	42.81	6.00e-63	236.00
IUUC-Tur-126149	Triticum urartu	38.06	1.00e-102	367.00
IUUC-Tbe-127672	Tupaia belangeri	91.73	0.00e+00	1253.00
IUUC-Ttr-128441	Tursiops truncatus	94.63	0.00e+00	1157.00
IUUC-Vpa-130469	Vicugna pacos	96.70	0.00e+00	1810.00
IUUC-Xtr-132729	Xenopus tropicalis	81.95	0.00e+00	1606.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence