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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045929
UUCD1 version UUC-HoS-00674
Ensembl Protein ID ENSP00000385957.1
UniProt Accession Q3ZCT8; B5MCC6; Q6ZRK1; KBTBC_HUMAN
Genbank Protein ID BAC87309.1; AAH41365.1
Protein Name Kelch repeat and BTB domain-containing protein 12; Kelch domain-containing protein 6
Genbank Nucleotide ID AK128176; AC011311
Gene Name KBTBD12; KLHDC6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000187715.13 ENST00000405109.5 ENSP00000385957.1
ENSG00000187715.13 ENST00000343941.4 ENSP00000345478.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACRepTarmiRcode
RAID2
Protein-protein Interaction
IID
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 8.60e-15 56.5 32 97
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           Dv+l  +ge+f++h++vLaa S++F+a+f+ +l e + + +v + d+ +e++++ll+++Y   l++n
   Q: 32   DVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECN-QREVILYDITAESVSVLLNYMYNAALEIN 97
           9***********************************9.99999999**************9999877 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MECKIEGKEK YQHSLNLLNK IQNMKELAEM IDVVLTAEGE KFPCHRLVLA AFSPYFKAMF 60
TCGLLECNQR EVILYDITAE SVSVLLNYMY NAALEINNAN VQTVAMAAYF MQMEEVFSVC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045929|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTAGGGTAC GGGACGCGCG CGGGGAGACC CTGTGCAGCG ACACCGGGGC TGTAGTCGCC 60
GTCTGGAACC AGCGCGGGAA TAGGTGCGCA GGCGCACAGT GGCTGGAGGG CAGCGGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045929|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR030583--KBTBD12
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination
KEGG hsa:166348
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001776 Ailuropoda melanoleuca 94.06 0.00e+00 1251.00
IUUC-Atr-002689 Amborella trichopoda 26.70 2.00e-12 68.20
IUUC-Apl-003332 Anas platyrhynchos 60.60 3.00e-163 568.00
IUUC-Aca-004623 Anolis carolinensis 74.47 0.00e+00 975.00
IUUC-Ame-011728 Astyanax mexicanus 52.80 3.00e-163 568.00
IUUC-Bta-012317 Bos taurus 88.57 0.00e+00 1181.00
IUUC-Cja-019290 Callithrix jacchus 97.43 0.00e+00 1274.00
IUUC-Cfa-021266 Canis familiaris 94.06 0.00e+00 1251.00
IUUC-Cpo-021772 Cavia porcellus 82.23 0.00e+00 833.00
IUUC-Csa-023664 Chlorocebus sabaeus 98.23 0.00e+00 1283.00
IUUC-Cho-024591 Choloepus hoffmanni 93.90 0.00e+00 1236.00
IUUC-Cne-026897 Cryptococcus neoformans 28.38 2.00e-05 43.10
IUUC-Dre-027589 Danio rerio 56.45 0.00e+00 758.00
IUUC-Dno-029391 Dasypus novemcinctus 92.44 0.00e+00 1117.00
IUUC-Eca-033880 Equus caballus 94.77 0.00e+00 1230.00
IUUC-Fca-035817 Felis catus 92.77 0.00e+00 975.00
IUUC-Fal-036724 Ficedula albicollis 74.15 0.00e+00 980.00
IUUC-Gmo-039367 Gadus morhua 56.28 0.00e+00 724.00
IUUC-Gga-040614 Gallus gallus 75.44 0.00e+00 995.00
IUUC-Gac-042556 Gasterosteus aculeatus 55.92 0.00e+00 751.00
IUUC-Ggo-045033 Gorilla gorilla 99.52 0.00e+00 1297.00
IUUC-Itr-048905 Ictidomys tridecemlineatus 74.80 0.00e+00 1031.00
IUUC-Lch-049468 Latimeria chalumnae 71.97 0.00e+00 959.00
IUUC-Loc-051833 Lepisosteus oculatus 66.77 0.00e+00 846.00
IUUC-Laf-054398 Loxodonta africana 93.42 0.00e+00 1229.00
IUUC-Mcc-055291 Macaca mulatta 98.23 0.00e+00 1283.00
IUUC-Meu-056489 Macropus eugenii 87.02 3.00e-147 515.00
IUUC-Mga-059993 Meleagris gallopavo 75.77 0.00e+00 994.00
IUUC-Mdo-062319 Monodelphis domestica 85.61 0.00e+00 983.00
IUUC-Mmu-063448 Mus musculus 91.81 0.00e+00 1207.00
IUUC-Mpu-066103 Mustela putorius furo 94.22 0.00e+00 1248.00
IUUC-Mlu-067022 Myotis lucifugus 91.33 0.00e+00 1215.00
IUUC-Nle-070134 Nomascus leucogenys 98.88 0.00e+00 1286.00
IUUC-Ont-071709 Oreochromis niloticus 57.33 0.00e+00 771.00
IUUC-Oan-073552 Ornithorhynchus anatinus 82.07 1.00e-178 619.00
IUUC-Ocu-074816 Oryctolagus cuniculus 90.35 0.00e+00 1201.00
IUUC-Ogl-077188 Oryza glaberrima 25.14 3.00e-12 67.40
IUUC-Ogu-078976 Oryza glumaepatula 25.14 4.00e-12 67.40
IUUC-Oin-079187 Oryza indica 25.14 4.00e-12 67.40
IUUC-Ome-081730 Oryza meridionalis 25.14 2.00e-12 67.80
IUUC-Opu-084126 Oryza punctata 25.14 1.00e-12 68.90
IUUC-Oru-084212 Oryza rufipogon 25.14 4.00e-12 67.00
IUUC-Osa-086263 Oryza sativa 25.14 4.00e-12 67.00
IUUC-Ola-086547 Oryzias latipes 56.68 0.00e+00 760.00
IUUC-Oga-088839 Otolemur garnettii 92.78 0.00e+00 1193.00
IUUC-Oar-089437 Ovis aries 86.63 0.00e+00 1139.00
IUUC-Ptr-091376 Pan troglodytes 99.36 0.00e+00 1296.00
IUUC-Pan-091712 Papio anubis 98.23 0.00e+00 1281.00
IUUC-Psi-093561 Pelodiscus sinensis 77.22 0.00e+00 1026.00
IUUC-Pfo-097373 Poecilia formosa 56.84 0.00e+00 773.00
IUUC-Ppe-101749 Prunus persica 27.27 1.00e-10 62.40
IUUC-Pva-102970 Pteropus vampyrus 93.20 0.00e+00 1221.00
IUUC-Pte-104106 Pyrenophora teres 28.75 1.00e-08 53.90
IUUC-Rno-105313 Rattus norvegicus 89.96 0.00e+00 944.00
IUUC-Sha-107452 Sarcophilus harrisii 85.28 0.00e+00 1088.00
IUUC-Sbi-114832 Sorghum bicolor 24.57 2.00e-12 67.80
IUUC-Ssc-115267 Sus scrofa 92.13 0.00e+00 1218.00
IUUC-Tgu-116756 Taeniopygia guttata 73.53 0.00e+00 869.00
IUUC-Tru-118549 Takifugu rubripes 56.08 0.00e+00 750.00
IUUC-Tsy-119476 Tarsius syrichta 91.01 0.00e+00 1187.00
IUUC-Tni-119910 Tetraodon nigroviridis 56.89 0.00e+00 733.00
IUUC-Ttr-128579 Tursiops truncatus 93.26 0.00e+00 1232.00
IUUC-Vpa-130107 Vicugna pacos 87.93 0.00e+00 905.00
IUUC-Xtr-132794 Xenopus tropicalis 68.41 0.00e+00 906.00
IUUC-Xma-133374 Xiphophorus maculatus 57.82 0.00e+00 777.00
Created Date 25-Jun-2017

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