iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021378

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02049846

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000004507.3	ENSCPOT00000004556.2	ENSCPOP00000004067.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.40e-07	29.9	68	129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 68   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 129
           5689*****************************999999*****************999977 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC TAMASSCSTA AKDDSVSGMT STSTGTLSGS FMEEIQGYDV 60
EFDPPLESKY ECPICLMALR EAVQTPCGHR FCKACIIKSI RDAGHKCPVD NEILLENQLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGT TAAACTGTGA AAACAGCTGT GGATCCAGCC AGTCTGAGAG TGACTGCTGC 60
ACTGCCATGG CCAGCTCCTG CAGCACTGCA GCAAAGGATG ACAGTGTGAG CGGGATGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	92.27	0.00e+00	982.00
IUUC-Apl-004062	Anas platyrhynchos	73.45	0.00e+00	835.00
IUUC-Aca-004636	Anolis carolinensis	70.86	0.00e+00	768.00
IUUC-Ame-011682	Astyanax mexicanus	53.35	9.00e-167	580.00
IUUC-Bta-012692	Bos taurus	89.34	0.00e+00	979.00
IUUC-Cja-019426	Callithrix jacchus	88.40	0.00e+00	960.00
IUUC-Cfa-020948	Canis familiaris	91.85	0.00e+00	872.00
IUUC-Csa-024045	Chlorocebus sabaeus	89.32	0.00e+00	972.00
IUUC-Cho-024973	Choloepus hoffmanni	74.02	5.00e-105	374.00
IUUC-Csv-026300	Ciona savignyi	39.43	2.00e-47	182.00
IUUC-Dre-027557	Danio rerio	56.54	2.00e-177	615.00
IUUC-Dno-030032	Dasypus novemcinctus	89.94	6.00e-155	540.00
IUUC-Dor-030790	Dipodomys ordii	88.95	0.00e+00	962.00
IUUC-Dse-031478	Dothistroma septosporum	24.30	5.00e-10	59.30
IUUC-Dme-031921	Drosophila melanogaster	27.61	2.00e-40	159.00
IUUC-Ete-032952	Echinops telfairi	83.19	4.00e-166	577.00
IUUC-Eca-033924	Equus caballus	86.97	0.00e+00	896.00
IUUC-Eeu-034734	Erinaceus europaeus	81.25	0.00e+00	850.00
IUUC-Fca-036222	Felis catus	84.38	0.00e+00	865.00
IUUC-Fal-036834	Ficedula albicollis	75.21	0.00e+00	742.00
IUUC-Fox-037935	Fusarium oxysporum	28.84	2.00e-21	96.70
IUUC-Gmo-039061	Gadus morhua	61.22	3.00e-89	322.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.23	1.00e-11	65.10
IUUC-Gga-040599	Gallus gallus	74.08	0.00e+00	845.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.28	8.00e-170	590.00
IUUC-Ggo-044508	Gorilla gorilla	83.49	0.00e+00	889.00
IUUC-Hsa-046349	Homo sapiens	89.13	0.00e+00	998.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	90.24	0.00e+00	996.00
IUUC-Lch-049821	Latimeria chalumnae	66.91	0.00e+00	757.00
IUUC-Loc-051995	Lepisosteus oculatus	58.45	0.00e+00	642.00
IUUC-Laf-054115	Loxodonta africana	86.37	0.00e+00	961.00
IUUC-Mcc-055298	Macaca mulatta	88.95	0.00e+00	966.00
IUUC-Mor-057263	Magnaporthe oryzae	28.24	3.00e-16	79.70
IUUC-Mpo-057517	Magnaporthe poae	28.77	4.00e-14	73.20
IUUC-Mga-059340	Meleagris gallopavo	73.71	0.00e+00	820.00
IUUC-Mvi-060553	Microbotryum violaceum	27.68	1.00e-14	74.30
IUUC-Mmr-061063	Microcebus murinus	90.98	0.00e+00	978.00
IUUC-Mdo-062075	Monodelphis domestica	79.63	0.00e+00	899.00
IUUC-Mmu-063780	Mus musculus	87.11	0.00e+00	919.00
IUUC-Mpu-065748	Mustela putorius furo	91.71	0.00e+00	981.00
IUUC-Mlu-067888	Myotis lucifugus	88.95	0.00e+00	967.00
IUUC-Ncr-068632	Neurospora crassa	27.50	2.00e-15	77.80
IUUC-Nle-069234	Nomascus leucogenys	89.13	0.00e+00	971.00
IUUC-Opr-070393	Ochotona princeps	94.84	5.00e-121	427.00
IUUC-Ont-072459	Oreochromis niloticus	54.14	3.00e-176	611.00
IUUC-Oan-073578	Ornithorhynchus anatinus	83.33	0.00e+00	931.00
IUUC-Ocu-074201	Oryctolagus cuniculus	91.71	0.00e+00	990.00
IUUC-Ola-087319	Oryzias latipes	57.36	2.00e-89	323.00
IUUC-Olu-087748	Ostreococcus lucimarinus	24.30	3.00e-09	55.80
IUUC-Oga-087936	Otolemur garnettii	88.21	0.00e+00	960.00
IUUC-Oar-089379	Ovis aries	89.34	0.00e+00	986.00
IUUC-Ptr-090758	Pan troglodytes	89.50	0.00e+00	971.00
IUUC-Pan-092590	Papio anubis	89.13	0.00e+00	967.00
IUUC-Psi-093948	Pelodiscus sinensis	71.85	0.00e+00	813.00
IUUC-Pma-094434	Petromyzon marinus	44.44	4.00e-129	454.00
IUUC-Pfo-096912	Poecilia formosa	53.72	1.00e-168	586.00
IUUC-Pab-097651	Pongo abelii	89.50	0.00e+00	973.00
IUUC-Pop-099898	Populus trichocarpa	26.45	2.00e-08	53.90
IUUC-Pca-100958	Procavia capensis	83.42	0.00e+00	695.00
IUUC-Pva-103247	Pteropus vampyrus	89.76	1.00e-126	446.00
IUUC-Rno-104994	Rattus norvegicus	85.45	0.00e+00	924.00
IUUC-Sha-106494	Sarcophilus harrisii	80.88	0.00e+00	922.00
IUUC-Sar-113375	Sorex araneus	85.66	0.00e+00	924.00
IUUC-Sre-115218	Sporisorium reilianum	28.19	3.00e-17	83.60
IUUC-Ssc-115417	Sus scrofa	90.62	0.00e+00	998.00
IUUC-Tgu-117232	Taeniopygia guttata	72.43	0.00e+00	802.00
IUUC-Tru-118321	Takifugu rubripes	55.85	5.00e-169	587.00
IUUC-Tni-120475	Tetraodon nigroviridis	53.44	1.00e-163	569.00
IUUC-Tbe-127719	Tupaia belangeri	78.35	0.00e+00	817.00
IUUC-Ttr-129264	Tursiops truncatus	88.24	3.00e-123	435.00
IUUC-Uma-129620	Ustilago maydis	27.51	9.00e-19	88.60
IUUC-Vpa-130244	Vicugna pacos	87.84	2.00e-125	442.00
IUUC-Xtr-131948	Xenopus tropicalis	64.99	0.00e+00	756.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence