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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064110
UUCD1 version UUC-MuM-01062
Ensembl Protein ID ENSMUSP00000037939.8
UniProt Accession Q7TSS2; Q29ST1; Q3UIY3; Q6P913; Q80UT5; Q8K2T0; Q9D7E1; UB2Q1_MOUSE
Genbank Protein ID AAY23286.1; AAM60815.1; BAB26217.2; BAE27373.1; AAH30044.2; AAH51487.1; AAH60966.1; AAH82275.1
Protein Name Ubiquitin-conjugating enzyme E2 Q1; E2 ubiquitin-conjugating enzyme Q1; Galactosyl transferase-associated protein; Ubiquitin carrier protein Q1; Ubiquitin-protein ligase Q1
Genbank Nucleotide ID AY945937; AY112699; AK009324; AK146707; BC030044; BC051487; BC060966; BC082275
Gene Name Ube2q1; Ube2q
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042572.12 ENSMUST00000038356.12 ENSMUSP00000037939.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 20682791
Classification
Family E-value Score Start End
E2/UBC 7.50e-19 69.0 314 406
Active Site
Position(s) Description Evidence
351 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388}
Domain Profile

   E2/UBC
   S: 46   vFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvllsiqsll..aepnpesplneeaaellkknre 131
           +  l+++f++++Pf+PP v+++++++++ +    G++C+++l +++ Ws+a+s+esv+++i ++l   +++++ ++n+++++l++++++
   Q: 314  FILLNFSFKDNFPFDPPFVRVVSPVLSGGYVLGgGAICMELL-TKQGWSSAYSIESVIMQISATLvkGKARVQFGANKSQYSLTRAQQS 401
           45689***********************999998********.59********************77789************9999998 PP
   S: 132  eykkkv 137
            yk+ v
   Q: 402  -YKSLV 406
           .99887 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Involved in female fertility and embryo implantation (PubMed:23108111). May be involved in hormonal homeostasis in females (Probable). Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (PubMed:18511602).
 Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Involved in female fertility and embryo implantation (PubMed:23108111). May be involved in hormonal homeostasis in females (Probable). Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (PubMed:18511602).
Protein Sequence
(Fasta)
MQQPQPQGQQ QPGPGQQLGV QGAAPGAGGG PGGGPGPGPC LRRELKLLES IFHRGHERFR 60
IASACLDELS CEFLLAGAGG AGAGAAPGPH LPSRGSVPGD PVRIHCNITE SYPAVPPIWS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064110|E2,E2/UBC|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGGATCAG GAAGTGCGGA CCGCGGCGGC GGCGGAGCCC GGAGCGGAGG CCGGAGGCTC 60
CCGGCCCGCC GGCCCCGGAG CGGAGCGGAG CGGAGGATGC AGCAGCCGCA GCCGCAGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064110|E2,E2/UBC|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005829--C:cytosol
GO:0030175--C:filopodium
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0007566--P:embryo implantation
GO:0009566--P:fertilization
GO:0007617--P:mating behavior
GO:0070459--P:prolactin secretion
GO:0061458--P:reproductive system development
GO:0001967--P:suckling behavior
KEGG mmu:70093
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001442 Ailuropoda melanoleuca 98.87 2.00e-179 621.00
IUUC-Apl-003281 Anas platyrhynchos 94.95 3.00e-153 534.00
IUUC-Aca-004783 Anolis carolinensis 56.21 5.00e-49 186.00
IUUC-Bta-012947 Bos taurus 99.48 0.00e+00 706.00
IUUC-Cja-019951 Callithrix jacchus 99.48 0.00e+00 707.00
IUUC-Cfa-020682 Canis familiaris 98.41 0.00e+00 662.00
IUUC-Cpo-022277 Cavia porcellus 99.48 0.00e+00 704.00
IUUC-Cre-022858 Chlamydomonas reinhardtii 31.52 1.00e-13 71.20
IUUC-Csa-023839 Chlorocebus sabaeus 99.48 0.00e+00 706.00
IUUC-Cho-024360 Choloepus hoffmanni 100.00 5.00e-74 270.00
IUUC-Csv-025853 Ciona savignyi 36.29 2.00e-20 92.80
IUUC-Dno-029771 Dasypus novemcinctus 97.52 1.00e-172 599.00
IUUC-Dor-030292 Dipodomys ordii 96.37 3.00e-146 511.00
IUUC-Eca-034172 Equus caballus 99.46 0.00e+00 673.00
IUUC-Eeu-034522 Erinaceus europaeus 97.39 0.00e+00 682.00
IUUC-Fca-036468 Felis catus 95.22 2.00e-151 528.00
IUUC-Fal-037276 Ficedula albicollis 95.22 3.00e-164 570.00
IUUC-Gga-041233 Gallus gallus 86.33 3.00e-171 594.00
IUUC-Ggo-044565 Gorilla gorilla 95.82 0.00e+00 699.00
IUUC-Hsa-046811 Homo sapiens 99.48 0.00e+00 706.00
IUUC-Itr-048119 Ictidomys tridecemlineatus 99.74 0.00e+00 706.00
IUUC-Lch-049417 Latimeria chalumnae 88.74 0.00e+00 647.00
IUUC-Laf-053736 Loxodonta africana 91.49 0.00e+00 642.00
IUUC-Mcc-055356 Macaca mulatta 99.48 0.00e+00 706.00
IUUC-Meu-056466 Macropus eugenii 76.76 7.00e-147 513.00
IUUC-Mga-059752 Meleagris gallopavo 90.13 3.00e-162 564.00
IUUC-Mvi-060299 Microbotryum violaceum 28.96 2.00e-13 72.40
IUUC-Mmr-061169 Microcebus murinus 99.22 0.00e+00 704.00
IUUC-Mdo-062451 Monodelphis domestica 99.69 5.00e-178 616.00
IUUC-Mpu-065975 Mustela putorius furo 98.61 0.00e+00 633.00
IUUC-Mlu-067549 Myotis lucifugus 98.96 0.00e+00 692.00
IUUC-Nle-069199 Nomascus leucogenys 99.48 0.00e+00 706.00
IUUC-Ocu-074575 Oryctolagus cuniculus 94.75 0.00e+00 642.00
IUUC-Oga-088404 Otolemur garnettii 98.66 0.00e+00 652.00
IUUC-Oar-089852 Ovis aries 99.22 0.00e+00 704.00
IUUC-Ptr-091578 Pan troglodytes 99.48 0.00e+00 706.00
IUUC-Pan-092384 Papio anubis 99.48 0.00e+00 706.00
IUUC-Psi-093619 Pelodiscus sinensis 89.24 3.00e-146 510.00
IUUC-Pma-094631 Petromyzon marinus 71.28 2.00e-137 481.00
IUUC-Ppa-095767 Physcomitrella patens 37.40 8.00e-17 83.20
IUUC-Pab-098221 Pongo abelii 99.48 0.00e+00 706.00
IUUC-Pca-100506 Procavia capensis 81.72 5.00e-155 540.00
IUUC-Pva-103011 Pteropus vampyrus 90.46 3.00e-174 604.00
IUUC-Rno-105296 Rattus norvegicus 100.00 0.00e+00 709.00
IUUC-Sha-107320 Sarcophilus harrisii 99.68 8.00e-172 595.00
IUUC-Ssc-115905 Sus scrofa 99.48 0.00e+00 706.00
IUUC-Tbe-127490 Tupaia belangeri 99.37 2.00e-173 601.00
Created Date 25-Jun-2017

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