iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040939

Ensembl Protein ID

ENSGALP00000022287.4

UniProt Accession

Q90Z16; OPTN_CHICK

Genbank Protein ID

AAK69306.1; AAM73640.1

Protein Name

Optineurin; Ag9-C5; FIP-2

Genbank Nucleotide ID

AF380358; AF389351

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000013738.6	ENSGALT00000022327.6	ENSGALP00000022287.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	4.50e-22	78.1	433	492

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +ee+let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+ + l+d ++ s
   Q: 433  QEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLAVQLAYLLKEQQNLEDLGRSS 492
           79***************************************************9988765 PP

Organism

Gallus gallus

Functional Description
(View)

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.

Protein Sequence
(Fasta)

MSSKPQIRPA ENGEHCRSKM ENGMDSMAPP TLSTYTPEEM VQQMKELITE NNELKEAMKL 60
HNQAMKDRYE ELSIWREKQK EEREFYETKF KEAKQCLLAK CVENEQLQQQ LQSLKEREEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCGCGC CGTGAGCGGG GTGAGCGCTG CCCGGGGCCG GGATGGGGAA AAGCTGCGGG 60
GAGCGGCGGT CGCGGCCTCC GGTGGAGGCT GAGGCGGCGG CGGAGGGCCC GGCAGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005776--C:autophagosome
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

gga:374079

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	54.73	1.00e-140	492.00
IUUC-Apl-003812	Anas platyrhynchos	86.14	0.00e+00	911.00
IUUC-Aca-004625	Anolis carolinensis	63.17	6.00e-179	620.00
IUUC-Aly-005781	Arabidopsis lyrata	50.00	6.90e-02	31.60
IUUC-Ame-011116	Astyanax mexicanus	37.30	4.00e-65	241.00
IUUC-Bta-013240	Bos taurus	56.27	7.00e-158	550.00
IUUC-Bol-016499	Brassica oleracea	29.73	1.60e+00	27.30
IUUC-Cja-019911	Callithrix jacchus	57.51	5.00e-155	540.00
IUUC-Cfa-020330	Canis familiaris	56.00	3.00e-146	511.00
IUUC-Cpo-021753	Cavia porcellus	54.04	9.00e-145	506.00
IUUC-Csa-023662	Chlorocebus sabaeus	57.19	1.00e-154	539.00
IUUC-Cho-024574	Choloepus hoffmanni	47.98	2.00e-73	269.00
IUUC-Dre-027720	Danio rerio	43.26	1.00e-96	346.00
IUUC-Dno-029079	Dasypus novemcinctus	55.92	3.00e-135	475.00
IUUC-Dor-030890	Dipodomys ordii	55.36	2.00e-152	532.00
IUUC-Dme-032072	Drosophila melanogaster	30.34	1.00e-05	44.30
IUUC-Ete-032568	Echinops telfairi	56.21	4.00e-137	481.00
IUUC-Eca-033528	Equus caballus	55.80	4.00e-147	514.00
IUUC-Eeu-035219	Erinaceus europaeus	53.79	8.00e-141	493.00
IUUC-Fca-035852	Felis catus	55.03	2.00e-145	509.00
IUUC-Fal-036862	Ficedula albicollis	87.25	0.00e+00	866.00
IUUC-Gmo-038735	Gadus morhua	39.96	1.00e-75	276.00
IUUC-Gac-041580	Gasterosteus aculeatus	43.63	1.00e-94	340.00
IUUC-Ggo-045034	Gorilla gorilla	52.81	3.00e-137	481.00
IUUC-Hsa-046624	Homo sapiens	59.14	3.00e-158	551.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	51.29	3.00e-138	485.00
IUUC-Lch-049720	Latimeria chalumnae	47.93	2.00e-77	282.00
IUUC-Loc-052185	Lepisosteus oculatus	45.10	2.00e-108	385.00
IUUC-Laf-054079	Loxodonta africana	53.82	8.00e-142	496.00
IUUC-Mcc-055674	Macaca mulatta	57.62	1.00e-153	536.00
IUUC-Meu-056769	Macropus eugenii	71.95	5.00e-63	235.00
IUUC-Mga-060203	Meleagris gallopavo	95.70	0.00e+00	956.00
IUUC-Mmr-061492	Microcebus murinus	56.17	9.00e-146	509.00
IUUC-Mdo-063051	Monodelphis domestica	57.19	3.00e-165	574.00
IUUC-Mmu-063409	Mus musculus	53.86	1.00e-153	536.00
IUUC-Mpu-065907	Mustela putorius furo	51.78	2.00e-141	495.00
IUUC-Mlu-066957	Myotis lucifugus	57.12	3.00e-142	498.00
IUUC-Nle-069973	Nomascus leucogenys	57.29	7.00e-153	533.00
IUUC-Opr-071049	Ochotona princeps	52.78	4.00e-133	468.00
IUUC-Ont-071915	Oreochromis niloticus	43.09	3.00e-99	355.00
IUUC-Oan-072965	Ornithorhynchus anatinus	56.85	4.00e-160	557.00
IUUC-Ocu-074029	Oryctolagus cuniculus	53.41	2.00e-125	442.00
IUUC-Ola-087019	Oryzias latipes	40.07	4.00e-87	315.00
IUUC-Oga-088613	Otolemur garnettii	56.72	6.00e-153	533.00
IUUC-Oar-090386	Ovis aries	55.77	4.00e-159	554.00
IUUC-Ptr-091619	Pan troglodytes	58.78	2.00e-156	545.00
IUUC-Pan-092178	Papio anubis	57.34	3.00e-154	538.00
IUUC-Psi-093214	Pelodiscus sinensis	67.02	0.00e+00	658.00
IUUC-Pfo-096901	Poecilia formosa	42.34	6.00e-90	324.00
IUUC-Pab-097560	Pongo abelii	63.81	2.00e-113	402.00
IUUC-Pca-100853	Procavia capensis	47.29	4.00e-59	222.00
IUUC-Pva-102255	Pteropus vampyrus	53.48	1.00e-129	456.00
IUUC-Rno-105812	Rattus norvegicus	53.08	1.00e-153	536.00
IUUC-Sha-107225	Sarcophilus harrisii	62.60	1.00e-118	419.00
IUUC-Sar-113736	Sorex araneus	56.35	1.00e-89	323.00
IUUC-Ssc-115422	Sus scrofa	55.65	2.00e-152	532.00
IUUC-Tgu-116924	Taeniopygia guttata	78.98	0.00e+00	762.00
IUUC-Tru-117695	Takifugu rubripes	41.90	2.00e-86	312.00
IUUC-Tsy-119090	Tarsius syrichta	51.82	6.00e-77	281.00
IUUC-Tni-120645	Tetraodon nigroviridis	40.55	1.00e-87	317.00
IUUC-Tbe-127970	Tupaia belangeri	65.02	2.00e-94	339.00
IUUC-Ttr-129244	Tursiops truncatus	56.67	2.00e-148	518.00
IUUC-Vpa-130313	Vicugna pacos	56.45	2.00e-146	512.00
IUUC-Xtr-132115	Xenopus tropicalis	44.87	1.00e-104	373.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence