iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008816

Ensembl Protein ID

CADAFUAP00007967

UniProt Accession

Q4WQI1; CREB_ASPFU

Genbank Protein ID

EAL89503.2

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase creB; Carbon catabolite repression protein B; Deubiquitinating enzyme creB; Ubiquitin thioesterase creB; Ubiquitin-hydrolyzing enzyme creB; Ubiquitin-specific-processing protease creB

Genbank Nucleotide ID

AAHF01000005

Gene Name

AFUA_4G12910; creB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00007967	CADAFUAT00007967	CADAFUAP00007967

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-88	296.3	56	467

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
419	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.................................................... 42
           G++N+    Y+NS+LQcL+   ++re++ + ++ +++ e+                                                     
   Q: 56   GMENVRWLSYCNSILQCLYYSVPFREAVIN-YPTRTPIESLeaalakslrypnpnaqleaeaqaekqkaanaqrpgmppnpqqkpedkdspey 147
           899999999*********************.54444444334555666666667777777888889999999999********9999999999 PP
   S: 43   ....................kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk..ek 111
                                +++++l +sl+++fe+++  +s+ + + p+++l++l++ +e+f++ ++qDa+Efl+ ll+++  +++   +k
   Q: 148  kkkmalqtlplletqnnassYGMSESLFTSLKDIFESVVgsQSRIGIIRPQQFLEVLRRDHEMFRTAMHQDAHEFLNLLLNEVVANVEAeaSK 240
           9999999999999999999889999*************99999999*****************************************774444 PP
   S: 112  nkpkeeeeeedkselsde...aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeele 201
           + p+e++  + +++ s +   +  +k+  ++ ++++lF+g l+s+++cl+c++vs+r+e fldls+++++++     s+++cL++f++ee+l+
   Q: 241  QPPIEKSLPAPETADSVDqssSTGSKTPNTTRWVHELFEGLLTSETQCLTCEKVSQRDEVFLDLSVDLEQHS-----SVTSCLRKFSAEEMLC 328
           44444444444444444422244455555559****************************************.....9*************** PP
   S: 202  genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssG 293
           ++nk++c++c ++qeaek++k+k+lP++L lhLkRf+++e+ ++ +k++ +v +p +L l  f+t+++ ++  ++ YeL+avvvH G ++ +G
   Q: 329  ERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRL--FNTTDDAED-PDRLYELYAVVVHIGgGPYHG 418
           *******************************************************88887..566645544.49******************* PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetg.....staYvlfYkr 337
           HYva++k e+++WllfdD+ V++v+++ v+++ g     + aYvlfY++
   Q: 419  HYVAIIKTEDRGWLLFDDEMVEPVDKNYVKNFFGdkpglACAYVLFYQE 467
           *******************************999*************97 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).

Protein Sequence
(Fasta)

MGSFLRSFRH NGGSTAPSVG AVPAKKEPQP PPMTPLEKRL LDMGPIREDG SDKFYGMENV 60
RWLSYCNSIL QCLYYSVPFR EAVINYPTRT PIESLEAALA KSLRYPNPNA QLEAEAQAEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTCGT TCCTGAGGAG TTTTCGCCAT AATGGGGTAT GTCCTTTAAC CCGTCCCTGT 60
GCCTACCGGT CAGGCTTTCT AGGCCGGAGG GCTTTCCCTT TGCCTGGCGC CATGTTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0045013--P:carbon catabolite repression of transcription
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

afm:AFUA_4G12910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	46.65	2.00e-83	300.00
IUUC-Aml-001964	Ailuropoda melanoleuca	50.50	2.00e-85	306.00
IUUC-Atr-002650	Amborella trichopoda	48.10	4.00e-83	299.00
IUUC-Apl-003411	Anas platyrhynchos	49.50	2.00e-84	304.00
IUUC-Aca-005212	Anolis carolinensis	50.84	3.00e-85	306.00
IUUC-Aly-005830	Arabidopsis lyrata	47.92	7.00e-78	282.00
IUUC-Ath-006663	Arabidopsis thaliana	47.00	1.00e-80	291.00
IUUC-Ago-007871	Ashbya gossypii	40.73	3.00e-63	234.00
IUUC-Acl-008239	Aspergillus clavatus	83.40	0.00e+00	1028.00
IUUC-Afl-008602	Aspergillus flavus	85.64	0.00e+00	891.00
IUUC-Ani-009137	Aspergillus nidulans	82.50	0.00e+00	812.00
IUUC-Ang-009703	Aspergillus niger	79.12	0.00e+00	801.00
IUUC-Aor-009901	Aspergillus oryzae	83.73	0.00e+00	796.00
IUUC-Ate-010431	Aspergillus terreus	85.87	0.00e+00	843.00
IUUC-Ame-011015	Astyanax mexicanus	50.50	8.00e-86	308.00
IUUC-Bgr-012071	Blumeria graminis	55.86	1.00e-160	558.00
IUUC-Bta-012981	Bos taurus	50.84	9.00e-86	308.00
IUUC-Bci-013837	Botrytis cinerea	60.96	7.00e-171	592.00
IUUC-Bdi-014008	Brachypodium distachyon	47.10	1.00e-82	298.00
IUUC-Bol-015138	Brassica oleracea	48.00	2.00e-78	284.00
IUUC-Bra-016956	Brassica rapa	47.44	2.00e-79	287.00
IUUC-Cel-018379	Caenorhabditis elegans	42.26	2.00e-74	271.00
IUUC-Cja-018831	Callithrix jacchus	50.50	1.00e-85	308.00
IUUC-Cfa-020534	Canis familiaris	50.17	6.00e-85	305.00
IUUC-Cpo-021703	Cavia porcellus	50.17	3.00e-85	306.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	47.02	3.00e-66	243.00
IUUC-Csa-023841	Chlorocebus sabaeus	47.83	3.00e-79	286.00
IUUC-Cho-024902	Choloepus hoffmanni	40.13	1.00e-57	215.00
IUUC-Cin-025659	Ciona intestinalis	39.39	7.00e-70	256.00
IUUC-Csv-025828	Ciona savignyi	39.24	2.00e-70	258.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	54.93	2.00e-172	597.00
IUUC-Cne-026900	Cryptococcus neoformans	39.13	2.00e-65	242.00
IUUC-Cme-027339	Cyanidioschyzon merolae	30.90	2.00e-37	148.00
IUUC-Dre-027845	Danio rerio	51.51	8.00e-87	311.00
IUUC-Dno-029460	Dasypus novemcinctus	49.50	7.00e-85	305.00
IUUC-Dor-030972	Dipodomys ordii	52.49	1.00e-75	275.00
IUUC-Dse-031470	Dothistroma septosporum	51.85	5.00e-175	606.00
IUUC-Dme-032038	Drosophila melanogaster	56.57	2.00e-68	251.00
IUUC-Ete-032659	Echinops telfairi	54.24	1.00e-54	205.00
IUUC-Eca-033439	Equus caballus	50.50	1.00e-85	307.00
IUUC-Eeu-034916	Erinaceus europaeus	50.21	4.00e-65	239.00
IUUC-Fca-035524	Felis catus	50.50	5.00e-85	306.00
IUUC-Fal-036833	Ficedula albicollis	50.50	6.00e-85	305.00
IUUC-Fox-037682	Fusarium oxysporum	56.72	1.00e-163	568.00
IUUC-Fso-038299	Fusarium solani	56.44	3.00e-154	537.00
IUUC-Gmo-038763	Gadus morhua	50.33	2.00e-85	307.00
IUUC-Ggr-039806	Gaeumannomyces graminis	57.31	3.00e-172	597.00
IUUC-Gga-041151	Gallus gallus	49.50	2.00e-84	303.00
IUUC-Gac-041967	Gasterosteus aculeatus	51.51	6.00e-86	308.00
IUUC-Gma-043101	Glycine max	48.22	3.00e-84	303.00
IUUC-Ggo-044659	Gorilla gorilla	47.83	6.00e-79	285.00
IUUC-Hsa-045700	Homo sapiens	50.50	1.00e-85	308.00
IUUC-Hvu-047692	Hordeum vulgare	46.60	1.00e-81	295.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	50.50	1.00e-85	307.00
IUUC-Kpa-049250	Komagataella pastoris	50.78	3.00e-94	337.00
IUUC-Lch-050435	Latimeria chalumnae	50.17	3.00e-84	303.00
IUUC-Lpe-051368	Leersia perrieri	45.40	2.00e-79	287.00
IUUC-Loc-051968	Lepisosteus oculatus	49.50	7.00e-84	301.00
IUUC-Lma-053300	Leptosphaeria maculans	57.31	0.00e+00	631.00
IUUC-Laf-053887	Loxodonta africana	50.50	2.00e-85	307.00
IUUC-Mcc-055701	Macaca mulatta	50.50	1.00e-85	308.00
IUUC-Mor-057072	Magnaporthe oryzae	62.31	9.00e-169	585.00
IUUC-Mpo-057424	Magnaporthe poae	59.76	2.00e-171	594.00
IUUC-Mtr-057715	Medicago truncatula	48.10	2.00e-83	300.00
IUUC-Mla-059142	Melampsora laricipopulina	54.52	3.00e-101	361.00
IUUC-Mga-059195	Meleagris gallopavo	49.50	3.00e-84	303.00
IUUC-Mvi-060357	Microbotryum violaceum	55.63	8.00e-86	310.00
IUUC-Mmr-060751	Microcebus murinus	50.50	2.00e-85	307.00
IUUC-Mdo-062735	Monodelphis domestica	50.50	2.00e-85	307.00
IUUC-Mmu-063263	Mus musculus	50.50	1.00e-84	304.00
IUUC-Mac-065323	Musa acuminata	47.40	8.00e-79	285.00
IUUC-Mpu-066038	Mustela putorius furo	47.83	1.00e-79	288.00
IUUC-Mlu-068128	Myotis lucifugus	50.50	1.00e-85	307.00
IUUC-Nfi-068611	Neosartorya fischeri	92.60	0.00e+00	1154.00
IUUC-Ncr-068699	Neurospora crassa	58.32	2.00e-170	590.00
IUUC-Nle-069767	Nomascus leucogenys	50.50	1.00e-85	308.00
IUUC-Opr-070980	Ochotona princeps	48.16	1.00e-79	287.00
IUUC-Ont-072658	Oreochromis niloticus	51.51	7.00e-86	308.00
IUUC-Oan-073372	Ornithorhynchus anatinus	49.50	5.00e-84	302.00
IUUC-Ocu-074322	Oryctolagus cuniculus	50.84	3.00e-85	306.00
IUUC-Oba-075220	Oryza barthii	45.95	2.00e-79	287.00
IUUC-Obr-076208	Oryza brachyantha	46.43	3.00e-76	276.00
IUUC-Ogl-077216	Oryza glaberrima	45.95	2.00e-79	287.00
IUUC-Ogu-078836	Oryza glumaepatula	45.95	2.00e-79	287.00
IUUC-Oin-079522	Oryza indica	45.95	2.00e-79	287.00
IUUC-Olo-080882	Oryza longistaminata	45.95	2.00e-79	287.00
IUUC-Ome-081549	Oryza meridionalis	45.95	2.00e-79	287.00
IUUC-Oni-082982	Oryza nivara	45.95	2.00e-79	287.00
IUUC-Opu-083532	Oryza punctata	46.28	4.00e-80	289.00
IUUC-Oru-084568	Oryza rufipogon	45.95	2.00e-79	287.00
IUUC-Osa-085299	Oryza sativa	45.95	2.00e-79	287.00
IUUC-Ola-087418	Oryzias latipes	51.51	4.00e-86	309.00
IUUC-Olu-087809	Ostreococcus lucimarinus	43.81	1.00e-65	241.00
IUUC-Oga-088298	Otolemur garnettii	50.50	3.00e-85	306.00
IUUC-Oar-090269	Ovis aries	50.84	3.00e-85	306.00
IUUC-Ptr-090467	Pan troglodytes	50.50	1.00e-85	308.00
IUUC-Pan-092437	Papio anubis	50.33	2.00e-84	304.00
IUUC-Psi-092993	Pelodiscus sinensis	50.17	3.00e-85	306.00
IUUC-Pma-094388	Petromyzon marinus	48.50	6.00e-81	292.00
IUUC-Pno-095044	Phaeosphaeria nodorum	60.46	3.00e-179	620.00
IUUC-Ppa-095415	Physcomitrella patens	49.34	9.00e-83	298.00
IUUC-Pfo-097052	Poecilia formosa	51.51	1.00e-85	308.00
IUUC-Pab-097797	Pongo abelii	50.50	1.00e-85	308.00
IUUC-Pop-099798	Populus trichocarpa	49.05	4.00e-84	303.00
IUUC-Pca-100835	Procavia capensis	52.28	2.00e-69	254.00
IUUC-Ppe-101474	Prunus persica	47.62	4.00e-83	299.00
IUUC-Pva-102878	Pteropus vampyrus	50.51	2.00e-85	307.00
IUUC-Pgr-103306	Puccinia graminis	54.40	3.00e-103	368.00
IUUC-Pte-104356	Pyrenophora teres	56.74	0.00e+00	625.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	55.96	4.00e-160	556.00
IUUC-Rno-106060	Rattus norvegicus	51.17	2.00e-85	307.00
IUUC-Sce-106367	Saccharomyces cerevisiae	41.64	9.00e-73	266.00
IUUC-Sha-107087	Sarcophilus harrisii	50.50	2.00e-85	307.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	40.59	8.00e-93	332.00
IUUC-Spo-108095	Schizosaccharomyces pombe	43.78	6.00e-105	372.00
IUUC-Smo-108674	Selaginella moellendorffii	50.50	4.00e-86	309.00
IUUC-Sit-110819	Setaria italica	45.93	1.00e-81	295.00
IUUC-Sly-111210	Solanum lycopersicum	48.87	9.00e-84	301.00
IUUC-Stu-112398	Solanum tuberosum	47.08	6.00e-81	292.00
IUUC-Sar-113216	Sorex araneus	49.50	2.00e-82	297.00
IUUC-Sbi-114724	Sorghum bicolor	46.77	4.00e-83	299.00
IUUC-Sre-115197	Sporisorium reilianum	55.12	3.00e-93	335.00
IUUC-Ssc-116321	Sus scrofa	50.50	1.00e-85	307.00
IUUC-Tgu-117482	Taeniopygia guttata	50.17	2.00e-83	300.00
IUUC-Tru-118613	Takifugu rubripes	51.51	5.00e-86	309.00
IUUC-Tsy-119520	Tarsius syrichta	54.68	7.00e-60	221.00
IUUC-Tni-120293	Tetraodon nigroviridis	51.51	5.00e-86	309.00
IUUC-Tca-121329	Theobroma cacao	48.67	7.00e-83	298.00
IUUC-Tre-122226	Trichoderma reesei	54.17	3.00e-166	577.00
IUUC-Tvi-122330	Trichoderma virens	55.09	8.00e-166	575.00
IUUC-Tae-124807	Triticum aestivum	47.91	8.00e-84	301.00
IUUC-Tur-126563	Triticum urartu	47.91	5.00e-84	302.00
IUUC-Tme-126890	Tuber melanosporum	66.07	6.00e-136	476.00
IUUC-Tbe-127783	Tupaia belangeri	50.50	1.00e-85	307.00
IUUC-Ttr-129083	Tursiops truncatus	50.84	6.00e-86	308.00
IUUC-Uma-129409	Ustilago maydis	55.59	2.00e-93	335.00
IUUC-Vda-129736	Verticillium dahliae	50.17	1.00e-152	531.00
IUUC-Vpa-130391	Vicugna pacos	47.49	3.00e-76	276.00
IUUC-Vvi-131371	Vitis vinifera	49.03	2.00e-84	303.00
IUUC-Xtr-132464	Xenopus tropicalis	49.67	3.00e-83	300.00
IUUC-Xma-133475	Xiphophorus maculatus	51.51	1.00e-85	308.00
IUUC-Yli-134632	Yarrowia lipolytica	59.78	4.00e-126	443.00
IUUC-Zma-134951	Zea mays	46.10	1.00e-81	295.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence