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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045742
UUCD1 version UUC-HoS-01019
Ensembl Protein ID ENSP00000403802.2
UniProt Accession Q9UK96; Q08AL3; Q08AL4; Q5JRT8; Q9UKC3; FBX10_HUMAN
Genbank Protein ID CAI16152.1; EAW58274.1; EAW58275.1; AAI25125.1; AAI25126.1; AAI40786.1; AAI71785.1; AAF03705.1; AAF04519.1
Protein Name F-box only protein 10
Genbank Nucleotide ID AL513165; CH471071; CH471071; BC125124; BC125125; BC140785; BC171785; AF176705; AF174598
Gene Name FBXO10; FBX10; PRMT11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000147912.12 ENST00000432825.6 ENSP00000403802.2
ENSG00000147912.12 ENST00000276960.7 ENSP00000276960.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 24008983
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.0068 18.1 6 47
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 106  lpeeilveilklldkeellraarvcrrwq.elas.qkalwkt 145
           lp+e++  il +l+ ++l+r+++vcr w+  + s +++ w++
   Q: 6    LPLELWRMILAYLHLPDLGRCSLVCRAWYeLILSlDSTRWRQ 47
           89***************************4444445666665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
Protein Sequence
(Fasta)
MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW 60
PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRRRERRTL SVGPGREFDS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045742|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCAGCTGTC CGCCCCCGGG CGGGGCTGGC CGCACGCCGC AATCCTACCG GCTGCTGCGG 60
CTCCAGCGGG GGCGGCGGGT GGCTTCCAGG GCACCGGCGG CCGCGGCCCG GACTCCGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045742|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR006633--Carb-bd_sugar_hydrolysis-dom
IPR001810--F-box_dom
IPR007742--NosD_dom
IPR022441--Para_beta_helix_rpt-2
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF05048--NosD
SMART

SM00722--CASH
SM00256--FBOX
SM00710--PbH1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042981--P:regulation of apoptotic process
KEGG hsa:26267
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001558 Ailuropoda melanoleuca 96.97 0.00e+00 1762.00
IUUC-Aca-004917 Anolis carolinensis 65.05 0.00e+00 1227.00
IUUC-Ame-011129 Astyanax mexicanus 51.21 0.00e+00 951.00
IUUC-Bta-012928 Bos taurus 89.02 0.00e+00 1630.00
IUUC-Cja-019383 Callithrix jacchus 96.73 0.00e+00 1158.00
IUUC-Cfa-020855 Canis familiaris 94.87 0.00e+00 1717.00
IUUC-Cpo-021873 Cavia porcellus 90.92 0.00e+00 1678.00
IUUC-Csa-024199 Chlorocebus sabaeus 99.27 0.00e+00 1818.00
IUUC-Dre-028495 Danio rerio 55.14 8.00e-171 594.00
IUUC-Dno-029707 Dasypus novemcinctus 94.56 0.00e+00 1728.00
IUUC-Dor-030668 Dipodomys ordii 90.61 0.00e+00 1665.00
IUUC-Ete-032489 Echinops telfairi 82.12 0.00e+00 918.00
IUUC-Eca-033534 Equus caballus 94.56 0.00e+00 1742.00
IUUC-Eeu-034536 Erinaceus europaeus 82.78 2.00e-158 553.00
IUUC-Fca-035906 Felis catus 96.34 0.00e+00 1751.00
IUUC-Gmo-039471 Gadus morhua 42.00 2.00e-168 586.00
IUUC-Ggr-039829 Gaeumannomyces graminis 42.50 1.30e-02 35.80
IUUC-Gac-041496 Gasterosteus aculeatus 45.08 8.00e-119 421.00
IUUC-Ggo-044503 Gorilla gorilla 99.90 0.00e+00 1827.00
IUUC-Itr-048727 Ictidomys tridecemlineatus 96.55 0.00e+00 1775.00
IUUC-Lch-049641 Latimeria chalumnae 64.92 0.00e+00 1229.00
IUUC-Loc-052060 Lepisosteus oculatus 53.89 0.00e+00 1000.00
IUUC-Laf-054216 Loxodonta africana 94.98 0.00e+00 1768.00
IUUC-Mcc-055122 Macaca mulatta 99.16 0.00e+00 1817.00
IUUC-Meu-056537 Macropus eugenii 64.21 0.00e+00 737.00
IUUC-Mpo-057323 Magnaporthe poae 42.50 3.40e-02 34.30
IUUC-Mmr-061489 Microcebus murinus 96.13 0.00e+00 1733.00
IUUC-Mdo-062954 Monodelphis domestica 67.39 0.00e+00 1282.00
IUUC-Mmu-064369 Mus musculus 92.57 0.00e+00 1746.00
IUUC-Mpu-065774 Mustela putorius furo 95.92 0.00e+00 1748.00
IUUC-Mlu-067093 Myotis lucifugus 95.29 0.00e+00 1764.00
IUUC-Nle-068989 Nomascus leucogenys 96.55 0.00e+00 1749.00
IUUC-Opr-070263 Ochotona princeps 87.97 0.00e+00 1719.00
IUUC-Ont-071949 Oreochromis niloticus 52.43 0.00e+00 947.00
IUUC-Oan-073316 Ornithorhynchus anatinus 59.03 8.00e-103 367.00
IUUC-Ocu-074369 Oryctolagus cuniculus 93.51 0.00e+00 1749.00
IUUC-Ola-086354 Oryzias latipes 51.03 0.00e+00 898.00
IUUC-Olu-087743 Ostreococcus lucimarinus 31.11 2.00e-04 40.80
IUUC-Oga-088392 Otolemur garnettii 95.40 0.00e+00 1749.00
IUUC-Oar-089595 Ovis aries 89.85 0.00e+00 1620.00
IUUC-Ptr-091635 Pan troglodytes 99.90 0.00e+00 1825.00
IUUC-Pan-091939 Papio anubis 99.27 0.00e+00 1815.00
IUUC-Psi-093872 Pelodiscus sinensis 70.45 4.00e-137 481.00
IUUC-Pma-094149 Petromyzon marinus 43.97 7.00e-122 431.00
IUUC-Ppa-095311 Physcomitrella patens 38.24 4.80e-02 32.70
IUUC-Pfo-097082 Poecilia formosa 52.15 1.00e-170 593.00
IUUC-Pab-098093 Pongo abelii 97.39 0.00e+00 1770.00
IUUC-Pca-101065 Procavia capensis 89.44 0.00e+00 1665.00
IUUC-Pva-102398 Pteropus vampyrus 91.45 0.00e+00 1064.00
IUUC-Rno-105341 Rattus norvegicus 92.89 0.00e+00 1726.00
IUUC-Sha-107170 Sarcophilus harrisii 63.02 0.00e+00 940.00
IUUC-Sar-112976 Sorex araneus 86.15 7.00e-130 458.00
IUUC-Ssc-115623 Sus scrofa 67.33 0.00e+00 1061.00
IUUC-Tru-118657 Takifugu rubripes 51.91 0.00e+00 946.00
IUUC-Tsy-119410 Tarsius syrichta 83.26 0.00e+00 642.00
IUUC-Tni-119696 Tetraodon nigroviridis 51.45 0.00e+00 955.00
IUUC-Tca-121485 Theobroma cacao 47.06 1.20e-02 34.70
IUUC-Tbe-128027 Tupaia belangeri 97.54 0.00e+00 1021.00
IUUC-Ttr-129142 Tursiops truncatus 90.68 0.00e+00 882.00
IUUC-Vpa-130738 Vicugna pacos 79.60 1.00e-109 390.00
IUUC-Xtr-132546 Xenopus tropicalis 63.36 0.00e+00 1240.00
Created Date 25-Jun-2017

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