iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	71.29	0.00e+00	1449.00	IUUC-Hsa-046520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (PubMed:24981866). Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (By similarity). Also has endonuclease activity toward 5'-flaps (PubMed:24981866).

Protein Sequence
(Fasta)

MPSQRKSPDQ KRPRRSLSTS KTAKSQCHSI TSYFNSAPPA KLACSTCHKM VPRYDLIRHL 60
DESCANNGVG DDVQVEPAQA GLMSPTVPTS DLPSGPLENV TPQKLSPPKR SLISVQCGSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAGCGCCT TGCTCTGGCT GGTCCGGGCT GCGCAGAGCG ACTGCCCGCC TTGTGGCCCT 60
TTGAGAGCGA CTCAGCCTGT TCCGCTGCAG TGAGTTCAGG GGAGTCTGAG CGAGTCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033315--Fan1-like
IPR011990--TPR-like_helical_dom
IPR014883--VRR_NUC

Pfam

PF08774--VRR_NUC

SMART

SM00990--VRR_NUC

Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0046872--F:metal ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0043130--F:ubiquitin binding
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0006289--P:nucleotide-excision repair
GO:0033683--P:nucleotide-excision repair, DNA incision

KEGG

mmu:330554

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000306	Aegilops tauschii	35.50	2.00e-60	226.00
IUUC-Aml-001380	Ailuropoda melanoleuca	70.16	0.00e+00	1377.00
IUUC-Atr-002873	Amborella trichopoda	30.67	4.00e-75	276.00
IUUC-Apl-003430	Anas platyrhynchos	66.26	0.00e+00	865.00
IUUC-Aca-005376	Anolis carolinensis	48.45	0.00e+00	842.00
IUUC-Aly-005463	Arabidopsis lyrata	30.77	2.00e-70	261.00
IUUC-Ath-007392	Arabidopsis thaliana	31.57	3.00e-73	270.00
IUUC-Acl-008285	Aspergillus clavatus	26.84	7.00e-60	225.00
IUUC-Afl-008680	Aspergillus flavus	27.68	7.00e-64	238.00
IUUC-Afu-008795	Aspergillus fumigatus	26.86	8.00e-57	215.00
IUUC-Ani-009329	Aspergillus nidulans	26.96	8.00e-56	212.00
IUUC-Ang-009526	Aspergillus niger	26.18	7.00e-51	195.00
IUUC-Aor-009880	Aspergillus oryzae	27.44	5.00e-63	236.00
IUUC-Ate-010269	Aspergillus terreus	27.95	8.00e-67	248.00
IUUC-Ame-011630	Astyanax mexicanus	45.12	0.00e+00	627.00
IUUC-Bgr-012168	Blumeria graminis	24.25	2.00e-36	147.00
IUUC-Bta-013504	Bos taurus	65.69	0.00e+00	1201.00
IUUC-Bci-013838	Botrytis cinerea	23.65	5.00e-50	192.00
IUUC-Bdi-014522	Brachypodium distachyon	30.01	3.00e-66	247.00
IUUC-Bol-016153	Brassica oleracea	31.83	8.00e-75	275.00
IUUC-Bra-017548	Brassica rapa	30.16	1.00e-63	238.00
IUUC-Cel-018711	Caenorhabditis elegans	31.13	7.00e-67	248.00
IUUC-Cja-018810	Callithrix jacchus	70.15	0.00e+00	1305.00
IUUC-Cfa-020147	Canis familiaris	70.13	0.00e+00	1383.00
IUUC-Cpo-021787	Cavia porcellus	68.74	0.00e+00	1310.00
IUUC-Cre-022863	Chlamydomonas reinhardtii	45.45	4.00e-03	33.10
IUUC-Csa-023730	Chlorocebus sabaeus	71.14	0.00e+00	1381.00
IUUC-Cho-024754	Choloepus hoffmanni	70.63	2.00e-125	442.00
IUUC-Cin-025459	Ciona intestinalis	49.11	1.00e-43	169.00
IUUC-Cgl-026724	Colletotrichum gloeosporioides	25.41	2.00e-43	171.00
IUUC-Cne-026815	Cryptococcus neoformans	25.18	6.00e-36	146.00
IUUC-Cme-027208	Cyanidioschyzon merolae	32.79	1.00e-26	115.00
IUUC-Dre-027725	Danio rerio	59.91	0.00e+00	759.00
IUUC-Dno-029713	Dasypus novemcinctus	67.28	0.00e+00	1326.00
IUUC-Dse-031534	Dothistroma septosporum	25.95	7.00e-42	166.00
IUUC-Ete-033004	Echinops telfairi	55.44	0.00e+00	757.00
IUUC-Eca-034119	Equus caballus	70.21	0.00e+00	1329.00
IUUC-Eeu-034618	Erinaceus europaeus	58.37	0.00e+00	1059.00
IUUC-Fca-035411	Felis catus	70.60	0.00e+00	1400.00
IUUC-Fal-037505	Ficedula albicollis	63.44	0.00e+00	811.00
IUUC-Fox-038070	Fusarium oxysporum	25.99	9.00e-53	202.00
IUUC-Fso-038376	Fusarium solani	26.15	3.00e-51	196.00
IUUC-Gmo-039093	Gadus morhua	59.20	0.00e+00	747.00
IUUC-Ggr-040081	Gaeumannomyces graminis	27.54	3.00e-51	197.00
IUUC-Gac-041973	Gasterosteus aculeatus	48.49	0.00e+00	836.00
IUUC-Gma-043421	Glycine max	31.07	7.00e-75	275.00
IUUC-Ggo-044431	Gorilla gorilla	71.07	0.00e+00	1376.00
IUUC-Hsa-046520	Homo sapiens	70.97	0.00e+00	1371.00
IUUC-Hvu-047632	Hordeum vulgare	31.44	2.00e-75	277.00
IUUC-Itr-048263	Ictidomys tridecemlineatus	73.40	0.00e+00	1440.00
IUUC-Lch-049799	Latimeria chalumnae	65.64	0.00e+00	909.00
IUUC-Lpe-051149	Leersia perrieri	32.37	4.00e-80	293.00
IUUC-Loc-051964	Lepisosteus oculatus	49.71	0.00e+00	846.00
IUUC-Lma-053161	Leptosphaeria maculans	25.64	3.00e-54	207.00
IUUC-Laf-054446	Loxodonta africana	67.97	0.00e+00	1290.00
IUUC-Mcc-055087	Macaca mulatta	70.94	0.00e+00	1377.00
IUUC-Meu-055930	Macropus eugenii	62.48	0.00e+00	657.00
IUUC-Mor-056966	Magnaporthe oryzae	28.41	4.00e-51	196.00
IUUC-Mpo-057393	Magnaporthe poae	27.69	1.00e-46	181.00
IUUC-Mtr-058315	Medicago truncatula	31.99	1.00e-77	285.00
IUUC-Mla-058859	Melampsora laricipopulina	25.12	5.00e-33	136.00
IUUC-Mga-059870	Meleagris gallopavo	66.82	0.00e+00	862.00
IUUC-Mvi-060226	Microbotryum violaceum	28.09	9.00e-49	188.00
IUUC-Mmr-060892	Microcebus murinus	71.47	0.00e+00	1379.00
IUUC-Mdo-062896	Monodelphis domestica	56.32	0.00e+00	1111.00
IUUC-Mac-064503	Musa acuminata	31.02	3.00e-69	256.00
IUUC-Mpu-066820	Mustela putorius furo	69.13	0.00e+00	1357.00
IUUC-Mlu-068131	Myotis lucifugus	63.24	0.00e+00	1148.00
IUUC-Nfi-068480	Neosartorya fischeri	25.88	2.00e-55	211.00
IUUC-Ncr-068646	Neurospora crassa	26.61	8.00e-60	225.00
IUUC-Nle-069545	Nomascus leucogenys	68.67	0.00e+00	1321.00
IUUC-Opr-070722	Ochotona princeps	82.21	0.00e+00	848.00
IUUC-Ont-072561	Oreochromis niloticus	46.21	0.00e+00	822.00
IUUC-Oan-072811	Ornithorhynchus anatinus	55.41	0.00e+00	1052.00
IUUC-Ocu-073884	Oryctolagus cuniculus	68.35	0.00e+00	1300.00
IUUC-Oba-075112	Oryza barthii	31.63	3.00e-62	233.00
IUUC-Obr-076057	Oryza brachyantha	32.21	7.00e-80	292.00
IUUC-Ogl-077002	Oryza glaberrima	31.29	3.00e-72	266.00
IUUC-Ogu-078683	Oryza glumaepatula	31.14	1.00e-60	228.00
IUUC-Oin-079952	Oryza indica	31.28	8.00e-61	229.00
IUUC-Olo-080278	Oryza longistaminata	31.05	3.00e-58	220.00
IUUC-Ome-081094	Oryza meridionalis	31.31	8.00e-61	229.00
IUUC-Oni-083059	Oryza nivara	31.56	6.00e-60	226.00
IUUC-Opu-084144	Oryza punctata	31.67	5.00e-76	279.00
IUUC-Oru-084897	Oryza rufipogon	29.82	4.00e-59	223.00
IUUC-Osa-085924	Oryza sativa	31.59	4.00e-72	266.00
IUUC-Oga-088979	Otolemur garnettii	69.74	0.00e+00	1327.00
IUUC-Oar-090362	Ovis aries	65.79	0.00e+00	1252.00
IUUC-Ptr-090823	Pan troglodytes	71.07	0.00e+00	1376.00
IUUC-Pan-092863	Papio anubis	71.23	0.00e+00	1383.00
IUUC-Psi-093006	Pelodiscus sinensis	53.28	0.00e+00	952.00
IUUC-Pma-094523	Petromyzon marinus	50.52	3.00e-134	471.00
IUUC-Pno-094770	Phaeosphaeria nodorum	26.77	5.00e-46	179.00
IUUC-Ppa-095372	Physcomitrella patens	32.03	4.00e-75	276.00
IUUC-Pfo-096875	Poecilia formosa	60.28	0.00e+00	786.00
IUUC-Pab-097665	Pongo abelii	71.89	0.00e+00	1355.00
IUUC-Pop-099082	Populus trichocarpa	32.46	1.00e-80	295.00
IUUC-Pca-100138	Procavia capensis	66.04	2.00e-120	427.00
IUUC-Ppe-101167	Prunus persica	26.89	1.00e-30	128.00
IUUC-Pva-103199	Pteropus vampyrus	61.34	4.00e-117	415.00
IUUC-Pgr-103480	Puccinia graminis	27.40	4.00e-43	170.00
IUUC-Ptt-103783	Puccinia triticina	30.27	6.00e-45	176.00
IUUC-Pte-104357	Pyrenophora teres	26.62	2.00e-44	174.00
IUUC-Pyt-104788	Pyrenophora triticirepentis	27.64	9.00e-51	195.00
IUUC-Rno-104958	Rattus norvegicus	85.66	0.00e+00	1703.00
IUUC-Sha-106828	Sarcophilus harrisii	56.06	0.00e+00	1150.00
IUUC-Sja-107731	Schizosaccharomyces japonicus	30.00	7.00e-47	182.00
IUUC-Spo-108086	Schizosaccharomyces pombe	25.14	3.00e-42	167.00
IUUC-Ssl-108610	Sclerotinia sclerotiorum	25.76	8.00e-49	189.00
IUUC-Smo-108690	Selaginella moellendorffii	34.95	1.00e-82	301.00
IUUC-Sit-110385	Setaria italica	37.29	1.00e-51	198.00
IUUC-Sly-111187	Solanum lycopersicum	32.38	2.00e-76	280.00
IUUC-Stu-112673	Solanum tuberosum	43.90	3.00e-33	134.00
IUUC-Sar-113548	Sorex araneus	52.38	1.00e-175	610.00
IUUC-Sbi-114131	Sorghum bicolor	37.81	8.00e-61	228.00
IUUC-Sre-114921	Sporisorium reilianum	38.46	1.00e-32	135.00
IUUC-Ssc-115484	Sus scrofa	68.27	0.00e+00	1289.00
IUUC-Tgu-116749	Taeniopygia guttata	64.36	0.00e+00	816.00
IUUC-Tru-118772	Takifugu rubripes	60.59	0.00e+00	749.00
IUUC-Tsy-119359	Tarsius syrichta	73.11	0.00e+00	1100.00
IUUC-Tni-120878	Tetraodon nigroviridis	47.08	0.00e+00	786.00
IUUC-Tca-120912	Theobroma cacao	32.61	1.00e-80	294.00
IUUC-Tre-122171	Trichoderma reesei	26.31	5.00e-58	219.00
IUUC-Tvi-122483	Trichoderma virens	27.11	1.00e-56	214.00
IUUC-Tae-125125	Triticum aestivum	31.90	4.00e-74	273.00
IUUC-Tur-126497	Triticum urartu	32.00	3.00e-73	270.00
IUUC-Tbe-127473	Tupaia belangeri	63.26	9.00e-91	327.00
IUUC-Ttr-128458	Tursiops truncatus	65.80	0.00e+00	1211.00
IUUC-Uma-129558	Ustilago maydis	40.10	5.00e-34	139.00
IUUC-Vda-129683	Verticillium dahliae	25.53	2.00e-51	197.00
IUUC-Vpa-130201	Vicugna pacos	56.29	1.00e-124	441.00
IUUC-Vvi-131226	Vitis vinifera	35.57	8.00e-65	241.00
IUUC-Xtr-132517	Xenopus tropicalis	45.15	0.00e+00	767.00
IUUC-Xma-133763	Xiphophorus maculatus	59.82	0.00e+00	779.00
IUUC-Zma-135455	Zea mays	31.50	4.00e-78	286.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence