iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055448

Ensembl Protein ID

ENSMMUP00000026582.3

UniProt Accession

H9EPW4; F6WT88; H9EPW4_MACMU

Genbank Protein ID

AFE64423.1; AFH27844.1

Protein Name

Transitional endoplasmic reticulum ATPase

Genbank Nucleotide ID

JSUE03014797; JU471040

Gene Name

VCP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000020190.3	ENSMMUT00000028405.3	ENSMMUP00000026582.3
ENSMMUG00000020190.3	ENSMMUT00000046375.2	ENSMMUP00000039418.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	100.00	0.00e+00	1501.00	IUUC-Hsa-046162
UBD/Other/Other	70.36	0.00e+00	1098.00	IUUC-Sce-106244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK 60
GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCTG GAGCCGAGTG AGTGTGCGCG CGCCGTCCGC TTGCTGCGGC GGCGCGCGCC 60
GGGACCCGCG GCGCTGGGTA GGCCCGGCGG GGCCTGGCCG TGGGCGCGTC AGAGAGGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR003593--AAA+_ATPase
IPR005938--AAA_ATPase_CDC48
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase
IPR015415--Vps4_C

PROSITE

PS00674--AAA

Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N
PF09336--Vps4_C

SMART

SM00382--AAA
SM01072--CDC48_2
SM01073--CDC48_N

Gene Ontology

GO:0005829--C:cytosol
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0070062--C:extracellular exosome
GO:0005811--C:lipid particle
GO:0043209--C:myelin sheath
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0000502--C:proteasome complex
GO:0035861--C:site of double-strand break
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:1990730--C:VCP-NSFL1C complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0035800--F:deubiquitinase activator activity
GO:0003723--F:RNA binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070842--P:aggresome assembly
GO:0046034--P:ATP metabolic process
GO:0097352--P:autophagosome maturation
GO:0006302--P:double-strand break repair
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0072389--P:flavin adenine dinucleotide catabolic process
GO:0006734--P:NADH metabolic process
GO:2001171--P:positive regulation of ATP biosynthetic process
GO:1903007--P:positive regulation of Lys63-specific deubiquitinase activity
GO:0010918--P:positive regulation of mitochondrial membrane potential
GO:1903862--P:positive regulation of oxidative phosphorylation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031334--P:positive regulation of protein complex assembly
GO:0034214--P:protein hexamerization
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0016567--P:protein ubiquitination
GO:1903715--P:regulation of aerobic respiration
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0019985--P:translesion synthesis
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0019079--P:viral genome replication

KEGG

mcc:698707

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000524	Aegilops tauschii	80.58	0.00e+00	1197.00
IUUC-Aml-001849	Ailuropoda melanoleuca	99.50	0.00e+00	1493.00
IUUC-Atr-002619	Amborella trichopoda	80.13	0.00e+00	1244.00
IUUC-Apl-004070	Anas platyrhynchos	98.51	0.00e+00	1476.00
IUUC-Aca-004847	Anolis carolinensis	97.03	0.00e+00	1481.00
IUUC-Aly-005406	Arabidopsis lyrata	79.46	0.00e+00	1216.00
IUUC-Ath-006796	Arabidopsis thaliana	79.95	0.00e+00	1226.00
IUUC-Ago-008001	Ashbya gossypii	71.12	0.00e+00	1040.00
IUUC-Acl-008066	Aspergillus clavatus	73.18	0.00e+00	1104.00
IUUC-Afl-008505	Aspergillus flavus	72.87	0.00e+00	1125.00
IUUC-Afu-008840	Aspergillus fumigatus	73.60	0.00e+00	1127.00
IUUC-Ani-009368	Aspergillus nidulans	72.92	0.00e+00	1134.00
IUUC-Ang-009724	Aspergillus niger	73.21	0.00e+00	1130.00
IUUC-Aor-010204	Aspergillus oryzae	72.87	0.00e+00	1125.00
IUUC-Ate-010370	Aspergillus terreus	73.38	0.00e+00	1130.00
IUUC-Ame-011388	Astyanax mexicanus	96.53	0.00e+00	1437.00
IUUC-Bgr-012223	Blumeria graminis	71.96	0.00e+00	1141.00
IUUC-Bta-013188	Bos taurus	99.88	0.00e+00	1504.00
IUUC-Bci-013831	Botrytis cinerea	73.01	0.00e+00	1130.00
IUUC-Bdi-014967	Brachypodium distachyon	80.71	0.00e+00	1236.00
IUUC-Bol-016113	Brassica oleracea	79.92	0.00e+00	1226.00
IUUC-Bra-017796	Brassica rapa	79.92	0.00e+00	1229.00
IUUC-Cel-018243	Caenorhabditis elegans	79.05	0.00e+00	1202.00
IUUC-Cja-019904	Callithrix jacchus	99.26	0.00e+00	1455.00
IUUC-Cfa-020304	Canis familiaris	99.88	0.00e+00	1501.00
IUUC-Cpo-021518	Cavia porcellus	100.00	0.00e+00	1488.00
IUUC-Cre-022719	Chlamydomonas reinhardtii	79.76	0.00e+00	1219.00
IUUC-Csa-023444	Chlorocebus sabaeus	100.00	0.00e+00	1501.00
IUUC-Cho-024482	Choloepus hoffmanni	98.62	0.00e+00	1459.00
IUUC-Cin-025517	Ciona intestinalis	86.20	0.00e+00	1276.00
IUUC-Csv-026060	Ciona savignyi	86.71	0.00e+00	1329.00
IUUC-Cgl-026690	Colletotrichum gloeosporioides	73.38	0.00e+00	1151.00
IUUC-Cne-026910	Cryptococcus neoformans	72.33	0.00e+00	1165.00
IUUC-Cme-027145	Cyanidioschyzon merolae	76.00	0.00e+00	1155.00
IUUC-Dre-028487	Danio rerio	96.77	0.00e+00	1437.00
IUUC-Dno-029257	Dasypus novemcinctus	100.00	0.00e+00	1501.00
IUUC-Dor-030473	Dipodomys ordii	98.39	0.00e+00	1452.00
IUUC-Dse-031319	Dothistroma septosporum	71.03	0.00e+00	1097.00
IUUC-Dme-032203	Drosophila melanogaster	84.77	0.00e+00	1269.00
IUUC-Eca-033311	Equus caballus	98.88	0.00e+00	1477.00
IUUC-Eeu-035293	Erinaceus europaeus	99.25	0.00e+00	774.00
IUUC-Fca-036097	Felis catus	99.86	0.00e+00	1392.00
IUUC-Fal-037292	Ficedula albicollis	98.88	0.00e+00	1480.00
IUUC-Fox-037827	Fusarium oxysporum	73.24	0.00e+00	1150.00
IUUC-Fso-038226	Fusarium solani	73.20	0.00e+00	1157.00
IUUC-Gmo-039157	Gadus morhua	89.50	0.00e+00	1310.00
IUUC-Ggr-039951	Gaeumannomyces graminis	72.81	0.00e+00	1125.00
IUUC-Gga-041183	Gallus gallus	99.01	0.00e+00	1491.00
IUUC-Gac-042039	Gasterosteus aculeatus	95.16	0.00e+00	1426.00
IUUC-Gma-044090	Glycine max	77.28	0.00e+00	1253.00
IUUC-Ggo-045568	Gorilla gorilla	100.00	0.00e+00	1501.00
IUUC-Hsa-046162	Homo sapiens	100.00	0.00e+00	1501.00
IUUC-Hvu-047107	Hordeum vulgare	80.78	0.00e+00	998.00
IUUC-Itr-047885	Ictidomys tridecemlineatus	99.75	0.00e+00	1497.00
IUUC-Kpa-049220	Komagataella pastoris	68.86	0.00e+00	1102.00
IUUC-Lch-050657	Latimeria chalumnae	89.38	0.00e+00	1279.00
IUUC-Lpe-051083	Leersia perrieri	80.31	0.00e+00	1227.00
IUUC-Loc-052064	Lepisosteus oculatus	97.27	0.00e+00	1443.00
IUUC-Lma-053323	Leptosphaeria maculans	73.86	0.00e+00	1132.00
IUUC-Laf-054574	Loxodonta africana	99.75	0.00e+00	1489.00
IUUC-Meu-056316	Macropus eugenii	92.75	0.00e+00	1350.00
IUUC-Mor-057057	Magnaporthe oryzae	72.77	0.00e+00	1123.00
IUUC-Mpo-057406	Magnaporthe poae	73.07	0.00e+00	1120.00
IUUC-Mtr-057648	Medicago truncatula	79.92	0.00e+00	1246.00
IUUC-Mla-059156	Melampsora laricipopulina	76.51	0.00e+00	1205.00
IUUC-Mga-060004	Meleagris gallopavo	93.07	0.00e+00	1244.00
IUUC-Mvi-060488	Microbotryum violaceum	75.51	0.00e+00	1187.00
IUUC-Mmr-061027	Microcebus murinus	100.00	0.00e+00	1487.00
IUUC-Mdo-062159	Monodelphis domestica	99.50	0.00e+00	1493.00
IUUC-Mmu-063633	Mus musculus	100.00	0.00e+00	1501.00
IUUC-Mac-064919	Musa acuminata	79.58	0.00e+00	1231.00
IUUC-Mpu-066078	Mustela putorius furo	99.88	0.00e+00	1504.00
IUUC-Mlu-067757	Myotis lucifugus	99.88	0.00e+00	1501.00
IUUC-Nfi-068533	Neosartorya fischeri	73.60	0.00e+00	1120.00
IUUC-Ncr-068775	Neurospora crassa	73.62	0.00e+00	1095.00
IUUC-Nle-069424	Nomascus leucogenys	99.75	0.00e+00	1489.00
IUUC-Opr-071147	Ochotona princeps	98.70	0.00e+00	1449.00
IUUC-Ont-071351	Oreochromis niloticus	95.66	0.00e+00	1405.00
IUUC-Oan-073335	Ornithorhynchus anatinus	97.76	0.00e+00	1474.00
IUUC-Ocu-074072	Oryctolagus cuniculus	100.00	0.00e+00	1501.00
IUUC-Oba-075914	Oryza barthii	80.36	0.00e+00	1246.00
IUUC-Obr-076224	Oryza brachyantha	81.05	0.00e+00	1239.00
IUUC-Ogl-077282	Oryza glaberrima	80.49	0.00e+00	1250.00
IUUC-Ogu-078174	Oryza glumaepatula	80.36	0.00e+00	1246.00
IUUC-Oin-079103	Oryza indica	80.36	0.00e+00	1246.00
IUUC-Olo-080675	Oryza longistaminata	80.49	0.00e+00	1247.00
IUUC-Ome-081247	Oryza meridionalis	80.18	0.00e+00	1249.00
IUUC-Oni-082078	Oryza nivara	80.23	0.00e+00	1245.00
IUUC-Opu-083806	Oryza punctata	80.42	0.00e+00	1253.00
IUUC-Oru-084634	Oryza rufipogon	80.36	0.00e+00	1246.00
IUUC-Osa-085960	Oryza sativa	80.36	0.00e+00	1246.00
IUUC-Ola-086382	Oryzias latipes	95.30	0.00e+00	1401.00
IUUC-Olu-087839	Ostreococcus lucimarinus	78.50	0.00e+00	1207.00
IUUC-Oga-088037	Otolemur garnettii	99.75	0.00e+00	1491.00
IUUC-Oar-089684	Ovis aries	97.28	0.00e+00	1487.00
IUUC-Ptr-091378	Pan troglodytes	100.00	0.00e+00	1501.00
IUUC-Pan-092849	Papio anubis	100.00	0.00e+00	1501.00
IUUC-Psi-093725	Pelodiscus sinensis	96.59	0.00e+00	1392.00
IUUC-Pma-094537	Petromyzon marinus	89.43	0.00e+00	692.00
IUUC-Pno-094915	Phaeosphaeria nodorum	76.79	0.00e+00	1080.00
IUUC-Ppa-095632	Physcomitrella patens	79.84	0.00e+00	1196.00
IUUC-Pfo-097440	Poecilia formosa	95.41	0.00e+00	1403.00
IUUC-Pab-098469	Pongo abelii	100.00	0.00e+00	1501.00
IUUC-Pop-100047	Populus trichocarpa	80.39	0.00e+00	1248.00
IUUC-Pca-100399	Procavia capensis	95.53	0.00e+00	1405.00
IUUC-Ppe-101767	Prunus persica	78.91	0.00e+00	1246.00
IUUC-Pva-102426	Pteropus vampyrus	99.26	0.00e+00	1459.00
IUUC-Pgr-103599	Puccinia graminis	74.13	0.00e+00	1187.00
IUUC-Ptt-103740	Puccinia triticina	74.26	0.00e+00	1187.00
IUUC-Pte-104030	Pyrenophora teres	73.55	0.00e+00	1116.00
IUUC-Pyt-104541	Pyrenophora triticirepentis	73.64	0.00e+00	1115.00
IUUC-Rno-105144	Rattus norvegicus	99.88	0.00e+00	1498.00
IUUC-Sce-106244	Saccharomyces cerevisiae	69.97	0.00e+00	1049.00
IUUC-Sha-106589	Sarcophilus harrisii	99.62	0.00e+00	1482.00
IUUC-Sja-107673	Schizosaccharomyces japonicus	71.65	0.00e+00	1097.00
IUUC-Spo-108247	Schizosaccharomyces pombe	70.59	0.00e+00	1075.00
IUUC-Ssl-108642	Sclerotinia sclerotiorum	72.75	0.00e+00	1121.00
IUUC-Smo-108877	Selaginella moellendorffii	79.87	0.00e+00	1232.00
IUUC-Sit-110623	Setaria italica	80.08	0.00e+00	1244.00
IUUC-Sly-111151	Solanum lycopersicum	79.32	0.00e+00	1219.00
IUUC-Stu-111959	Solanum tuberosum	79.82	0.00e+00	1246.00
IUUC-Sar-113021	Sorex araneus	100.00	0.00e+00	1488.00
IUUC-Sbi-114457	Sorghum bicolor	80.75	0.00e+00	1249.00
IUUC-Sre-115052	Sporisorium reilianum	76.87	0.00e+00	1214.00
IUUC-Ssc-116293	Sus scrofa	99.63	0.00e+00	1499.00
IUUC-Tgu-116544	Taeniopygia guttata	95.88	0.00e+00	1394.00
IUUC-Tru-117991	Takifugu rubripes	94.92	0.00e+00	1000.00
IUUC-Tsy-119131	Tarsius syrichta	83.13	0.00e+00	1166.00
IUUC-Tni-120192	Tetraodon nigroviridis	93.92	0.00e+00	1392.00
IUUC-Tca-121502	Theobroma cacao	79.74	0.00e+00	1227.00
IUUC-Tre-122189	Trichoderma reesei	72.94	0.00e+00	1134.00
IUUC-Tvi-122310	Trichoderma virens	72.42	0.00e+00	1118.00
IUUC-Tae-124332	Triticum aestivum	80.58	0.00e+00	1214.00
IUUC-Tur-126733	Triticum urartu	80.31	0.00e+00	1200.00
IUUC-Tme-127147	Tuber melanosporum	73.37	0.00e+00	1112.00
IUUC-Tbe-127255	Tupaia belangeri	92.94	0.00e+00	1393.00
IUUC-Ttr-128876	Tursiops truncatus	99.37	0.00e+00	1472.00
IUUC-Uma-129448	Ustilago maydis	77.10	0.00e+00	1206.00
IUUC-Vda-129800	Verticillium dahliae	70.60	0.00e+00	1114.00
IUUC-Vpa-130573	Vicugna pacos	99.76	0.00e+00	837.00
IUUC-Vvi-131622	Vitis vinifera	80.65	0.00e+00	1250.00
IUUC-Xtr-132458	Xenopus tropicalis	97.78	0.00e+00	1392.00
IUUC-Xma-134045	Xiphophorus maculatus	95.53	0.00e+00	1403.00
IUUC-Yli-134382	Yarrowia lipolytica	72.02	0.00e+00	1129.00
IUUC-Zma-134817	Zea mays	80.49	0.00e+00	1253.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence