iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132965

Ensembl Protein ID

ENSXETP00000027417.2

UniProt Accession

F7BKF3; F7BKF3_XENTR

Genbank Protein ID

ENSXETP00000027417

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01069771

Gene Name

abl2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000012531.3	ENSXETT00000027417.2	ENSXETP00000027417.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-12	47.1	120	177

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W++     ++ +G +P+n+++ ++
   Q: 120  PNLFLALYDFVASGDNTLSITKGEKLRVL-CYNQNGEWCEV--LSKNGQGWVPSNYITPVN 177
           577889***********************.*********98..889999*********997 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MGQQVGRVGG EAPSAQQPHR GARGSGTKPS AHVGNIAATS SRRREATGRT NPETGFNIFT 60
QHVYLHTCCT NGNEGDFVTL CSFPEALHRP YGSDSEPQAL TDAIRWSSKE NLLGATESDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCCAGC AGGTAGGCCG CGTCGGAGGT GAAGCACCTA GTGCTCAACA GCCGCACAGA 60
GGAGCCAGAG GCAGCGGAAC CAAGCCAAGC GCACATGTGG GAAACATAGC AGCAACCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	70.65	0.00e+00	1424.00
IUUC-Bta-013370	Bos taurus	68.75	0.00e+00	1454.00
IUUC-Bra-017986	Brassica rapa	34.15	7.00e-21	95.90
IUUC-Cfa-020398	Canis familiaris	89.29	0.00e+00	1147.00
IUUC-Cpo-022367	Cavia porcellus	71.55	0.00e+00	1384.00
IUUC-Csa-023386	Chlorocebus sabaeus	74.92	0.00e+00	1296.00
IUUC-Cho-024714	Choloepus hoffmanni	84.57	0.00e+00	1218.00
IUUC-Dre-027741	Danio rerio	68.15	0.00e+00	1165.00
IUUC-Dno-029246	Dasypus novemcinctus	66.47	0.00e+00	1411.00
IUUC-Dor-030416	Dipodomys ordii	64.05	0.00e+00	1295.00
IUUC-Dme-032098	Drosophila melanogaster	63.83	0.00e+00	743.00
IUUC-Ete-032899	Echinops telfairi	78.55	2.00e-132	467.00
IUUC-Eca-033387	Equus caballus	74.33	0.00e+00	1308.00
IUUC-Eeu-035058	Erinaceus europaeus	63.39	0.00e+00	1329.00
IUUC-Fca-036578	Felis catus	76.89	0.00e+00	1219.00
IUUC-Fal-037491	Ficedula albicollis	71.60	0.00e+00	1446.00
IUUC-Gmo-038509	Gadus morhua	70.68	0.00e+00	1120.00
IUUC-Gga-040638	Gallus gallus	74.13	0.00e+00	1291.00
IUUC-Gac-042550	Gasterosteus aculeatus	63.87	0.00e+00	1217.00
IUUC-Ggo-044487	Gorilla gorilla	72.76	0.00e+00	1343.00
IUUC-Hsa-046636	Homo sapiens	72.76	0.00e+00	1342.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	73.83	0.00e+00	1301.00
IUUC-Lch-049530	Latimeria chalumnae	71.78	0.00e+00	1288.00
IUUC-Lpe-051291	Leersia perrieri	31.05	3.00e-21	97.40
IUUC-Loc-051933	Lepisosteus oculatus	71.52	0.00e+00	1239.00
IUUC-Laf-053802	Loxodonta africana	72.44	0.00e+00	1367.00
IUUC-Mcc-054836	Macaca mulatta	73.07	0.00e+00	1343.00
IUUC-Meu-056488	Macropus eugenii	58.38	0.00e+00	730.00
IUUC-Mga-059277	Meleagris gallopavo	71.26	0.00e+00	1428.00
IUUC-Mmr-061206	Microcebus murinus	72.69	0.00e+00	1317.00
IUUC-Mdo-062281	Monodelphis domestica	84.38	0.00e+00	1151.00
IUUC-Mmu-063847	Mus musculus	71.34	0.00e+00	1295.00
IUUC-Mac-065247	Musa acuminata	31.37	1.00e-21	98.60
IUUC-Mpu-066309	Mustela putorius furo	86.12	0.00e+00	1196.00
IUUC-Mlu-068070	Myotis lucifugus	76.00	0.00e+00	1301.00
IUUC-Nle-070062	Nomascus leucogenys	85.67	0.00e+00	1184.00
IUUC-Opr-070327	Ochotona princeps	69.39	0.00e+00	795.00
IUUC-Ont-072440	Oreochromis niloticus	64.29	0.00e+00	1145.00
IUUC-Oan-073526	Ornithorhynchus anatinus	75.45	0.00e+00	1290.00
IUUC-Ocu-074051	Oryctolagus cuniculus	74.36	0.00e+00	1271.00
IUUC-Oga-088767	Otolemur garnettii	67.66	0.00e+00	1121.00
IUUC-Oar-089800	Ovis aries	75.25	0.00e+00	1286.00
IUUC-Ptr-090857	Pan troglodytes	85.82	0.00e+00	1185.00
IUUC-Pan-092279	Papio anubis	68.03	0.00e+00	1449.00
IUUC-Psi-093573	Pelodiscus sinensis	76.81	0.00e+00	1286.00
IUUC-Pma-094420	Petromyzon marinus	74.64	0.00e+00	862.00
IUUC-Pfo-096543	Poecilia formosa	64.81	0.00e+00	1127.00
IUUC-Pab-097949	Pongo abelii	71.85	0.00e+00	1305.00
IUUC-Pca-100370	Procavia capensis	68.05	0.00e+00	828.00
IUUC-Pva-103220	Pteropus vampyrus	65.01	0.00e+00	1143.00
IUUC-Rno-105924	Rattus norvegicus	70.93	0.00e+00	1288.00
IUUC-Sha-107114	Sarcophilus harrisii	81.52	0.00e+00	1208.00
IUUC-Tgu-117301	Taeniopygia guttata	76.21	0.00e+00	1302.00
IUUC-Tru-118410	Takifugu rubripes	65.78	0.00e+00	1167.00
IUUC-Tni-119991	Tetraodon nigroviridis	66.63	0.00e+00	1176.00
IUUC-Tbe-127362	Tupaia belangeri	78.27	0.00e+00	1271.00
IUUC-Ttr-129291	Tursiops truncatus	68.88	0.00e+00	1425.00
IUUC-Vpa-130800	Vicugna pacos	79.90	0.00e+00	1248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence