iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040832

UUCD1 version

UUC-GaG-00122

Ensembl Protein ID

ENSGALP00000055208.1

UniProt Accession

A0A1D5PQP3; A0A1D5PQP3_CHICK

Genbank Protein ID

ENSGALP00000055208

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AADN04000060

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000040474.1	ENSGALT00000056005.1	ENSGALP00000055208.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.80e-137	456.9	545	877

Active Site

Position(s)	Description	Evidence
846	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 545  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 632
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle+vdpe+y+sl ++ken   diee+gl++ fsv++eilge+k+++Lkp+G+ni Vt+eNkeeY++lv+e
   Q: 633  GFSLPFYKRILNKPVGLKDLESVDPEFYNSLIWVKEN---DIEECGLEMFFSVDKEILGEIKSHDLKPNGSNILVTEENKEEYIRLVAE 718
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 719  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSRQILWFWQFVKEIDNEKRMRLLQFV 806
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+++e+lkekLl+Aieet+gF++
   Q: 807  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKNYEQLKEKLLFAIEETEGFGQ 877
           *********************************************************************96 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAGTGSKSGL PGGLYMKSQL QITVISAKLK EKNKWFGPSP YVEVSVDGQS KKTEKCNNTN 60
SPKWKQHLTV IVTPLSKLTF RVWSHQTLKS DVLLGSAALD IHETLKSNSM KLDQVVVTLH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCAAGATC CAGCCCATAT TATGGCTGGC ACTGGATCCA AGTCAGGATT ACCTGGTGGG 60
TTGTATATGA AATCACAGCT TCAGATCACT GGTAAGTTGT TTGAAATTAT GTATCTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

gga:419145

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	84.43	0.00e+00	1444.00
IUUC-Apl-003752	Anas platyrhynchos	95.61	0.00e+00	1619.00
IUUC-Aca-005338	Anolis carolinensis	86.35	0.00e+00	1491.00
IUUC-Ago-007742	Ashbya gossypii	49.05	2.00e-162	565.00
IUUC-Ame-010601	Astyanax mexicanus	86.63	0.00e+00	1114.00
IUUC-Bta-012782	Bos taurus	96.68	0.00e+00	1192.00
IUUC-Cja-018899	Callithrix jacchus	95.11	0.00e+00	1201.00
IUUC-Cfa-020648	Canis familiaris	83.33	0.00e+00	1409.00
IUUC-Cpo-022073	Cavia porcellus	81.76	0.00e+00	1462.00
IUUC-Csa-023252	Chlorocebus sabaeus	81.42	0.00e+00	1450.00
IUUC-Cho-024695	Choloepus hoffmanni	77.98	0.00e+00	1417.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.54	2.00e-155	542.00
IUUC-Dre-028451	Danio rerio	74.24	0.00e+00	1298.00
IUUC-Dno-029884	Dasypus novemcinctus	83.45	0.00e+00	1466.00
IUUC-Eca-033793	Equus caballus	83.33	0.00e+00	1448.00
IUUC-Eeu-034716	Erinaceus europaeus	90.61	0.00e+00	874.00
IUUC-Fca-035605	Felis catus	85.01	0.00e+00	1466.00
IUUC-Fal-037126	Ficedula albicollis	94.76	0.00e+00	1597.00
IUUC-Gmo-038596	Gadus morhua	80.55	0.00e+00	1006.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.60	4.00e-154	538.00
IUUC-Gac-041658	Gasterosteus aculeatus	85.83	0.00e+00	1116.00
IUUC-Ggo-044535	Gorilla gorilla	78.75	0.00e+00	1412.00
IUUC-Hsa-046564	Homo sapiens	77.87	0.00e+00	1434.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	81.67	0.00e+00	1414.00
IUUC-Kpa-049273	Komagataella pastoris	46.88	6.00e-164	570.00
IUUC-Lch-050454	Latimeria chalumnae	75.47	0.00e+00	1380.00
IUUC-Loc-052647	Lepisosteus oculatus	72.71	0.00e+00	1332.00
IUUC-Laf-054383	Loxodonta africana	81.76	0.00e+00	1461.00
IUUC-Mcc-055532	Macaca mulatta	81.20	0.00e+00	1448.00
IUUC-Mpo-057442	Magnaporthe poae	51.55	1.00e-144	507.00
IUUC-Mga-059661	Meleagris gallopavo	98.75	0.00e+00	1669.00
IUUC-Mmr-061135	Microcebus murinus	81.97	0.00e+00	1467.00
IUUC-Mdo-062505	Monodelphis domestica	87.66	0.00e+00	1498.00
IUUC-Mmu-063375	Mus musculus	96.58	0.00e+00	1212.00
IUUC-Mpu-066203	Mustela putorius furo	84.89	0.00e+00	1449.00
IUUC-Mlu-067837	Myotis lucifugus	83.22	0.00e+00	1457.00
IUUC-Nle-069244	Nomascus leucogenys	83.31	0.00e+00	1440.00
IUUC-Opr-070585	Ochotona princeps	79.39	0.00e+00	1419.00
IUUC-Ont-071798	Oreochromis niloticus	89.55	0.00e+00	1134.00
IUUC-Ocu-074298	Oryctolagus cuniculus	81.69	0.00e+00	1459.00
IUUC-Ola-086526	Oryzias latipes	86.03	0.00e+00	1112.00
IUUC-Oga-088167	Otolemur garnettii	78.26	0.00e+00	1329.00
IUUC-Oar-090316	Ovis aries	73.61	0.00e+00	839.00
IUUC-Ptr-090819	Pan troglodytes	77.42	0.00e+00	1398.00
IUUC-Pan-092454	Papio anubis	81.20	0.00e+00	1447.00
IUUC-Psi-093319	Pelodiscus sinensis	88.54	0.00e+00	1495.00
IUUC-Pfo-097346	Poecilia formosa	85.50	0.00e+00	1100.00
IUUC-Pab-097580	Pongo abelii	71.81	0.00e+00	1284.00
IUUC-Pca-100923	Procavia capensis	68.33	0.00e+00	1189.00
IUUC-Pva-103209	Pteropus vampyrus	81.27	0.00e+00	1398.00
IUUC-Rno-104924	Rattus norvegicus	82.28	0.00e+00	1439.00
IUUC-Sha-107175	Sarcophilus harrisii	84.20	0.00e+00	1483.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	50.09	2.00e-159	556.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.89	8.00e-163	567.00
IUUC-Sar-113761	Sorex araneus	96.34	0.00e+00	1186.00
IUUC-Tgu-116632	Taeniopygia guttata	87.62	0.00e+00	1435.00
IUUC-Tru-118442	Takifugu rubripes	88.91	0.00e+00	1120.00
IUUC-Tsy-119198	Tarsius syrichta	75.82	0.00e+00	1330.00
IUUC-Tni-120168	Tetraodon nigroviridis	87.46	0.00e+00	1057.00
IUUC-Tbe-127756	Tupaia belangeri	66.59	0.00e+00	1115.00
IUUC-Ttr-128504	Tursiops truncatus	74.62	0.00e+00	1010.00
IUUC-Vpa-130103	Vicugna pacos	68.73	0.00e+00	1199.00
IUUC-Xtr-132885	Xenopus tropicalis	75.84	0.00e+00	1384.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence