iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050086

Ensembl Protein ID

ENSLACP00000010253.1

UniProt Accession

H3AKT2; H3AKT2_LATCH

Genbank Protein ID

ENSLACP00000010253

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AFYH01122677

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000009033.1	ENSLACT00000010331.1	ENSLACP00000010253.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.70e-31	107.0	1018	1069

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C+vC  ++++e+ +++C++C++w+H+ C +l+ eee+++  +  + C+ Cr
   Q: 1018 TCPVCYLNYREEELILQCRQCDRWIHASCQNLNTEEEVETAADngFDCSMCR 1069
           6********************************999998887788******7 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

EIKGQNAEEG DVQAEADISE QLTPVLQRTA SEESTGSTAS VGVEVKTSNE KLCALCYCGE 60
RSLLGQGELK QFDPTPGFTV PWKSQSKSKK GSNDRLGDKN PKQNSVSRRQ RGQKKDRGSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATTAAAG GACAAAATGC AGAGGAGGGA GATGTCCAAG CAGAAGCAGA CATCAGTGAA 60
CAGTTAACAC CGGTTCTTCA GCGCACAGCA TCAGAGGAAT CCACAGGCTC CACTGCATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	61.28	0.00e+00	4689.00
IUUC-Apl-003311	Anas platyrhynchos	62.73	0.00e+00	4945.00
IUUC-Aca-004705	Anolis carolinensis	59.27	0.00e+00	4542.00
IUUC-Ame-010612	Astyanax mexicanus	72.20	0.00e+00	858.00
IUUC-Bta-012322	Bos taurus	61.36	0.00e+00	3830.00
IUUC-Bra-017422	Brassica rapa	33.51	4.00e-28	119.00
IUUC-Cel-018354	Caenorhabditis elegans	35.96	4.00e-63	238.00
IUUC-Cja-019983	Callithrix jacchus	61.32	0.00e+00	4786.00
IUUC-Cfa-020903	Canis familiaris	60.25	0.00e+00	4635.00
IUUC-Cpo-021732	Cavia porcellus	59.80	0.00e+00	4562.00
IUUC-Csa-023083	Chlorocebus sabaeus	55.86	0.00e+00	3266.00
IUUC-Cho-024469	Choloepus hoffmanni	52.48	0.00e+00	1167.00
IUUC-Dre-027995	Danio rerio	43.07	0.00e+00	1673.00
IUUC-Dno-029932	Dasypus novemcinctus	74.09	0.00e+00	875.00
IUUC-Dor-030569	Dipodomys ordii	59.76	0.00e+00	1872.00
IUUC-Dme-031590	Drosophila melanogaster	37.10	3.00e-61	230.00
IUUC-Ete-032572	Echinops telfairi	74.35	0.00e+00	752.00
IUUC-Eca-033945	Equus caballus	57.37	0.00e+00	3027.00
IUUC-Eeu-034848	Erinaceus europaeus	62.26	2.00e-100	363.00
IUUC-Fca-035922	Felis catus	60.29	0.00e+00	4570.00
IUUC-Fal-037179	Ficedula albicollis	74.34	0.00e+00	859.00
IUUC-Gmo-039403	Gadus morhua	50.41	0.00e+00	1398.00
IUUC-Gga-040815	Gallus gallus	67.32	3.00e-97	352.00
IUUC-Gac-041896	Gasterosteus aculeatus	49.12	0.00e+00	1383.00
IUUC-Ggo-044812	Gorilla gorilla	58.11	0.00e+00	4403.00
IUUC-Hsa-046595	Homo sapiens	61.75	0.00e+00	4809.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	61.11	0.00e+00	4580.00
IUUC-Loc-052891	Lepisosteus oculatus	53.14	0.00e+00	2219.00
IUUC-Laf-054348	Loxodonta africana	55.82	0.00e+00	1875.00
IUUC-Mcc-054868	Macaca mulatta	61.10	0.00e+00	4758.00
IUUC-Meu-055992	Macropus eugenii	75.23	0.00e+00	864.00
IUUC-Mga-059541	Meleagris gallopavo	62.63	0.00e+00	4804.00
IUUC-Mmr-061092	Microcebus murinus	55.59	0.00e+00	3221.00
IUUC-Mdo-062610	Monodelphis domestica	61.74	0.00e+00	1595.00
IUUC-Mmu-063666	Mus musculus	59.62	0.00e+00	4491.00
IUUC-Mac-064935	Musa acuminata	33.16	6.00e-28	119.00
IUUC-Mpu-066366	Mustela putorius furo	60.88	0.00e+00	4393.00
IUUC-Mlu-068201	Myotis lucifugus	66.72	0.00e+00	1891.00
IUUC-Nle-069232	Nomascus leucogenys	56.07	0.00e+00	3273.00
IUUC-Opr-070625	Ochotona princeps	50.91	0.00e+00	813.00
IUUC-Ont-072401	Oreochromis niloticus	57.57	0.00e+00	1047.00
IUUC-Oan-072945	Ornithorhynchus anatinus	56.91	0.00e+00	3166.00
IUUC-Ocu-074920	Oryctolagus cuniculus	59.98	0.00e+00	4619.00
IUUC-Ola-086436	Oryzias latipes	45.16	0.00e+00	1831.00
IUUC-Oga-088637	Otolemur garnettii	54.34	0.00e+00	2471.00
IUUC-Oar-089363	Ovis aries	60.52	0.00e+00	3745.00
IUUC-Ptr-091527	Pan troglodytes	61.58	0.00e+00	4839.00
IUUC-Pan-092102	Papio anubis	59.43	0.00e+00	4561.00
IUUC-Pma-094252	Petromyzon marinus	44.14	1.00e-105	378.00
IUUC-Ppa-095221	Physcomitrella patens	34.18	3.00e-28	120.00
IUUC-Pfo-096288	Poecilia formosa	47.42	0.00e+00	1305.00
IUUC-Pab-098241	Pongo abelii	61.17	0.00e+00	2982.00
IUUC-Pop-099585	Populus trichocarpa	31.94	4.00e-26	113.00
IUUC-Pca-100103	Procavia capensis	83.72	0.00e+00	1238.00
IUUC-Ppe-101920	Prunus persica	32.65	3.00e-25	110.00
IUUC-Pva-102238	Pteropus vampyrus	52.04	0.00e+00	1481.00
IUUC-Pgr-103522	Puccinia graminis	38.14	1.00e-14	75.50
IUUC-Rno-105660	Rattus norvegicus	72.87	0.00e+00	802.00
IUUC-Sha-106550	Sarcophilus harrisii	56.27	0.00e+00	3265.00
IUUC-Sar-113183	Sorex araneus	82.55	3.00e-137	484.00
IUUC-Sbi-113816	Sorghum bicolor	36.63	2.00e-12	67.80
IUUC-Ssc-115678	Sus scrofa	73.71	0.00e+00	867.00
IUUC-Tgu-116677	Taeniopygia guttata	62.57	0.00e+00	4662.00
IUUC-Tru-118037	Takifugu rubripes	48.16	0.00e+00	1468.00
IUUC-Tsy-118932	Tarsius syrichta	60.19	0.00e+00	3259.00
IUUC-Tni-119970	Tetraodon nigroviridis	53.53	0.00e+00	1299.00
IUUC-Tca-121624	Theobroma cacao	31.10	3.00e-26	114.00
IUUC-Tbe-127625	Tupaia belangeri	64.66	7.00e-96	347.00
IUUC-Ttr-129051	Tursiops truncatus	58.85	0.00e+00	4222.00
IUUC-Vpa-130236	Vicugna pacos	50.32	0.00e+00	947.00
IUUC-Xtr-132455	Xenopus tropicalis	49.52	0.00e+00	948.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence