iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117732

Ensembl Protein ID

ENSTRUP00000006028.1

UniProt Accession

H2S0V7; H2S0V7_TAKRU

Protein Name

Presenilin

Gene Name

psen1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000002589.1	ENSTRUT00000006065.1	ENSTRUP00000006028.1
ENSTRUG00000002589.1	ENSTRUT00000006066.1	ENSTRUP00000006029.1
ENSTRUG00000002589.1	ENSTRUT00000006067.1	ENSTRUP00000006030.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	7.70e-08	33.4	270	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++v+L+++++
   Q: 270  VETAQERNEPIFPALIYSSTMVWLVNMAD 298
           89************************987 PP

Organism

Takifugu rubripes

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

FTETPSELKN QEPSVVNHEP AVQPQEVSVT RSRSRGGGGH GEGGPEQNGQ PPATHAAHVV 60
ETEEDEDEEL TLKYGAKHVI MLFVPVTLCM VVVVATIKSV TYYTQNDGQR LIYTPFPEDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTACAGAAA CACCTTCAGT TCAGTCCTGG GGCACTTTTA GATCCTCGTG CACAAACATT 60
CTCCACAAAG TTTGGAAGGT TTTGGGCATC GTTACTGGTG AAAAGCTGTG ACTAAAGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	33.87	4.00e-24	106.00
IUUC-Aml-001648	Ailuropoda melanoleuca	73.77	2.00e-123	435.00
IUUC-Atr-003039	Amborella trichopoda	29.60	2.00e-33	137.00
IUUC-Apl-003727	Anas platyrhynchos	76.87	4.00e-146	511.00
IUUC-Aca-004582	Anolis carolinensis	77.06	5.00e-149	520.00
IUUC-Aly-005455	Arabidopsis lyrata	45.00	2.00e-17	83.60
IUUC-Ath-006730	Arabidopsis thaliana	30.00	6.00e-32	131.00
IUUC-Ame-011500	Astyanax mexicanus	80.90	1.00e-159	555.00
IUUC-Bta-013026	Bos taurus	74.21	1.00e-144	506.00
IUUC-Bdi-014196	Brachypodium distachyon	32.41	4.00e-28	119.00
IUUC-Bol-015841	Brassica oleracea	31.49	2.00e-31	130.00
IUUC-Bra-017580	Brassica rapa	58.62	4.00e-18	85.90
IUUC-Cel-018553	Caenorhabditis elegans	53.10	3.00e-101	362.00
IUUC-Cja-019994	Callithrix jacchus	76.56	7.00e-145	506.00
IUUC-Cfa-020074	Canis familiaris	76.56	8.00e-145	506.00
IUUC-Cpo-022237	Cavia porcellus	76.46	9.00e-144	503.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.18	3.00e-25	110.00
IUUC-Csa-023537	Chlorocebus sabaeus	70.17	8.00e-146	509.00
IUUC-Cho-024735	Choloepus hoffmanni	67.33	2.00e-127	449.00
IUUC-Cin-025780	Ciona intestinalis	60.84	3.00e-114	405.00
IUUC-Csv-025967	Ciona savignyi	61.22	5.00e-114	404.00
IUUC-Dre-028689	Danio rerio	82.58	2.00e-156	545.00
IUUC-Dno-029758	Dasypus novemcinctus	76.96	1.00e-144	506.00
IUUC-Dor-031127	Dipodomys ordii	73.17	9.00e-90	323.00
IUUC-Dme-031929	Drosophila melanogaster	55.80	1.00e-104	373.00
IUUC-Ete-033081	Echinops telfairi	55.81	4.00e-55	208.00
IUUC-Eca-034387	Equus caballus	66.58	6.00e-111	394.00
IUUC-Eeu-035134	Erinaceus europaeus	74.43	2.00e-109	388.00
IUUC-Fca-036243	Felis catus	76.56	3.00e-145	508.00
IUUC-Fal-036600	Ficedula albicollis	76.35	1.00e-148	519.00
IUUC-Gmo-039665	Gadus morhua	78.49	1.00e-121	429.00
IUUC-Gga-040993	Gallus gallus	76.17	2.00e-148	519.00
IUUC-Gac-042342	Gasterosteus aculeatus	81.25	2.00e-152	531.00
IUUC-Gma-043822	Glycine max	36.69	3.00e-21	95.90
IUUC-Ggo-045338	Gorilla gorilla	73.98	2.00e-93	336.00
IUUC-Hsa-046822	Homo sapiens	70.17	6.00e-146	510.00
IUUC-Hvu-047141	Hordeum vulgare	33.87	8.00e-26	111.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	64.23	5.00e-105	374.00
IUUC-Lch-049946	Latimeria chalumnae	70.19	4.00e-125	441.00
IUUC-Lpe-051132	Leersia perrieri	30.03	6.00e-27	115.00
IUUC-Loc-052469	Lepisosteus oculatus	67.84	8.00e-135	473.00
IUUC-Laf-053979	Loxodonta africana	73.74	9.00e-131	459.00
IUUC-Mcc-055682	Macaca mulatta	70.17	6.00e-146	510.00
IUUC-Meu-056004	Macropus eugenii	62.17	9.00e-114	403.00
IUUC-Mtr-058392	Medicago truncatula	34.68	2.00e-25	110.00
IUUC-Mga-059466	Meleagris gallopavo	76.17	1.00e-148	519.00
IUUC-Mmr-060890	Microcebus murinus	67.51	4.00e-112	397.00
IUUC-Mdo-062122	Monodelphis domestica	74.07	4.00e-145	508.00
IUUC-Mmu-063176	Mus musculus	70.43	7.00e-140	490.00
IUUC-Mac-064858	Musa acuminata	36.55	5.00e-19	88.20
IUUC-Mpu-065927	Mustela putorius furo	75.81	1.00e-143	503.00
IUUC-Mlu-067079	Myotis lucifugus	76.32	5.00e-147	514.00
IUUC-Nle-070180	Nomascus leucogenys	70.17	6.00e-146	510.00
IUUC-Opr-070847	Ochotona princeps	68.68	1.00e-137	483.00
IUUC-Ont-071846	Oreochromis niloticus	82.85	2.00e-179	621.00
IUUC-Oan-072783	Ornithorhynchus anatinus	75.86	2.00e-113	401.00
IUUC-Ocu-074527	Oryctolagus cuniculus	77.33	2.00e-144	506.00
IUUC-Oba-075256	Oryza barthii	31.23	5.00e-26	111.00
IUUC-Obr-076302	Oryza brachyantha	58.33	1.00e-15	77.80
IUUC-Ogl-077097	Oryza glaberrima	30.49	8.00e-27	114.00
IUUC-Ogu-078570	Oryza glumaepatula	30.49	7.00e-27	114.00
IUUC-Oin-079244	Oryza indica	30.39	1.00e-26	114.00
IUUC-Olo-080484	Oryza longistaminata	33.91	2.00e-22	99.40
IUUC-Ome-081814	Oryza meridionalis	31.28	6.00e-28	118.00
IUUC-Oni-082057	Oryza nivara	30.39	1.00e-26	114.00
IUUC-Opu-084176	Oryza punctata	58.33	9.00e-16	78.20
IUUC-Oru-084618	Oryza rufipogon	30.49	1.00e-26	114.00
IUUC-Osa-085602	Oryza sativa	30.49	9.00e-27	114.00
IUUC-Ola-086707	Oryzias latipes	79.07	3.00e-88	318.00
IUUC-Olu-087811	Ostreococcus lucimarinus	33.59	5.00e-39	154.00
IUUC-Oga-088560	Otolemur garnettii	66.08	7.00e-114	404.00
IUUC-Oar-090348	Ovis aries	76.32	1.00e-146	513.00
IUUC-Ptr-091060	Pan troglodytes	70.17	6.00e-146	510.00
IUUC-Pan-091855	Papio anubis	66.67	3.00e-128	451.00
IUUC-Psi-093505	Pelodiscus sinensis	75.93	4.00e-148	517.00
IUUC-Pma-094612	Petromyzon marinus	69.19	9.00e-120	423.00
IUUC-Ppa-095431	Physcomitrella patens	31.65	7.00e-24	105.00
IUUC-Pfo-097396	Poecilia formosa	85.32	0.00e+00	667.00
IUUC-Pab-098591	Pongo abelii	76.56	4.00e-145	507.00
IUUC-Pop-099661	Populus trichocarpa	32.51	8.00e-29	121.00
IUUC-Pca-101029	Procavia capensis	73.41	2.00e-133	469.00
IUUC-Ppe-101495	Prunus persica	29.60	3.00e-32	132.00
IUUC-Pva-102244	Pteropus vampyrus	73.42	3.00e-134	471.00
IUUC-Rno-105861	Rattus norvegicus	68.44	2.00e-139	489.00
IUUC-Sha-107045	Sarcophilus harrisii	75.36	1.00e-146	513.00
IUUC-Smo-109325	Selaginella moellendorffii	34.07	4.00e-34	139.00
IUUC-Sit-110624	Setaria italica	31.78	8.00e-25	108.00
IUUC-Sly-110865	Solanum lycopersicum	54.55	2.00e-06	43.90
IUUC-Stu-112433	Solanum tuberosum	30.34	2.00e-28	120.00
IUUC-Sar-113169	Sorex araneus	68.54	3.00e-107	382.00
IUUC-Sbi-114305	Sorghum bicolor	33.64	3.00e-26	113.00
IUUC-Ssc-115766	Sus scrofa	77.08	2.00e-145	509.00
IUUC-Tgu-117280	Taeniopygia guttata	69.33	3.00e-126	444.00
IUUC-Tsy-119624	Tarsius syrichta	64.29	5.00e-129	454.00
IUUC-Tni-119852	Tetraodon nigroviridis	85.08	0.00e+00	657.00
IUUC-Tca-121865	Theobroma cacao	30.18	1.00e-26	114.00
IUUC-Tae-125925	Triticum aestivum	35.46	2.00e-27	116.00
IUUC-Tur-126237	Triticum urartu	33.55	1.00e-25	110.00
IUUC-Tbe-128148	Tupaia belangeri	65.35	1.00e-102	366.00
IUUC-Ttr-128793	Tursiops truncatus	75.56	8.00e-140	489.00
IUUC-Vpa-130625	Vicugna pacos	63.54	1.00e-111	396.00
IUUC-Vvi-131312	Vitis vinifera	31.65	4.00e-30	125.00
IUUC-Xtr-131790	Xenopus tropicalis	77.78	2.00e-138	485.00
IUUC-Xma-133377	Xiphophorus maculatus	82.83	0.00e+00	632.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence