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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104953
UUCD1 version UUC-RaN-00631
Ensembl Protein ID ENSRNOP00000071182.1
UniProt Accession Q5U2S6; ASB2_RAT
Genbank Protein ID AAH85882.1
Protein Name Ankyrin repeat and SOCS box protein 2
Genbank Nucleotide ID BC085882
Gene Name Asb2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000051619.1 ENSRNOT00000085517.1 ENSRNOP00000071182.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 7.00e-18 64.6 582 633
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++ +++  + pr+L hLCRl++r+++g++r+k++d+LPLP +L++YL+ye++
   Q: 582  WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENT 633
           567899999*****************************************86 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MSTEISTRGR QRAIGHEEYS LYSSLSEEEL VQMAIEQSLA DKTRGPTPAE TSVSSQTNHQ 60
PGHIHPWTRS SSPPESPPAR APLGLFQGVM QKYSSNLFKT SQMAAMDPVL KAIKEGDEEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104953|E3,SOCS|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAAATCTG AGAGTCATAA CGTCTTATAG CTTGGCTTGA CATCCCTGGT CATGCGGTGG 60
GCCCGAAATA AACTCCCTGC TTCAAAGGAG AATGTTTCAG AGCTGCCTGG CACAACAGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104953|E3,SOCS|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG rno:299266
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002426 Ailuropoda melanoleuca 87.91 0.00e+00 1110.00
IUUC-Apl-003289 Anas platyrhynchos 68.87 0.00e+00 904.00
IUUC-Aca-004685 Anolis carolinensis 67.44 0.00e+00 891.00
IUUC-Ame-011522 Astyanax mexicanus 56.62 0.00e+00 654.00
IUUC-Bta-012533 Bos taurus 87.87 0.00e+00 1107.00
IUUC-Cja-018887 Callithrix jacchus 90.24 0.00e+00 1134.00
IUUC-Cfa-020241 Canis familiaris 86.61 0.00e+00 1038.00
IUUC-Cpo-021586 Cavia porcellus 87.66 0.00e+00 1070.00
IUUC-Csa-024206 Chlorocebus sabaeus 90.55 0.00e+00 1130.00
IUUC-Csv-025944 Ciona savignyi 38.66 3.00e-91 328.00
IUUC-Cme-027144 Cyanidioschyzon merolae 28.03 3.00e-18 88.20
IUUC-Dre-028150 Danio rerio 56.83 0.00e+00 644.00
IUUC-Dno-029859 Dasypus novemcinctus 86.66 0.00e+00 1077.00
IUUC-Dor-030375 Dipodomys ordii 82.28 0.00e+00 875.00
IUUC-Ete-032832 Echinops telfairi 90.10 0.00e+00 945.00
IUUC-Eca-033752 Equus caballus 87.87 0.00e+00 1100.00
IUUC-Eeu-034810 Erinaceus europaeus 83.15 6.00e-133 467.00
IUUC-Fca-036306 Felis catus 86.36 0.00e+00 1084.00
IUUC-Fal-037401 Ficedula albicollis 67.18 0.00e+00 860.00
IUUC-Ggr-040007 Gaeumannomyces graminis 27.13 4.00e-27 117.00
IUUC-Gga-040683 Gallus gallus 68.72 0.00e+00 875.00
IUUC-Gac-041891 Gasterosteus aculeatus 49.00 8.00e-156 543.00
IUUC-Ggo-044676 Gorilla gorilla 90.55 0.00e+00 1160.00
IUUC-Hsa-046276 Homo sapiens 92.64 0.00e+00 1082.00
IUUC-Itr-048291 Ictidomys tridecemlineatus 89.64 0.00e+00 1130.00
IUUC-Lch-050470 Latimeria chalumnae 61.47 0.00e+00 816.00
IUUC-Loc-052826 Lepisosteus oculatus 60.64 0.00e+00 707.00
IUUC-Laf-053868 Loxodonta africana 88.99 0.00e+00 1127.00
IUUC-Mcc-054926 Macaca mulatta 90.71 0.00e+00 1132.00
IUUC-Meu-056671 Macropus eugenii 77.52 0.00e+00 914.00
IUUC-Mga-059782 Meleagris gallopavo 67.95 0.00e+00 897.00
IUUC-Mmr-061793 Microcebus murinus 89.76 0.00e+00 1128.00
IUUC-Mdo-062521 Monodelphis domestica 76.93 0.00e+00 1041.00
IUUC-Mmu-063801 Mus musculus 97.32 0.00e+00 1231.00
IUUC-Mpu-066868 Mustela putorius furo 87.09 0.00e+00 1082.00
IUUC-Mlu-067101 Myotis lucifugus 86.19 0.00e+00 1026.00
IUUC-Nle-069551 Nomascus leucogenys 90.71 0.00e+00 1160.00
IUUC-Opr-071102 Ochotona princeps 94.03 0.00e+00 1078.00
IUUC-Ont-071648 Oreochromis niloticus 55.82 2.00e-172 599.00
IUUC-Oan-073719 Ornithorhynchus anatinus 74.50 0.00e+00 1016.00
IUUC-Ocu-074019 Oryctolagus cuniculus 86.27 0.00e+00 1049.00
IUUC-Oga-088029 Otolemur garnettii 88.38 0.00e+00 1105.00
IUUC-Oar-090209 Ovis aries 71.67 0.00e+00 835.00
IUUC-Ptr-090635 Pan troglodytes 90.88 0.00e+00 1136.00
IUUC-Pan-092406 Papio anubis 90.71 0.00e+00 1131.00
IUUC-Psi-093322 Pelodiscus sinensis 68.61 0.00e+00 919.00
IUUC-Pma-094270 Petromyzon marinus 45.59 4.00e-144 504.00
IUUC-Pfo-096482 Poecilia formosa 42.59 6.00e-135 474.00
IUUC-Pab-097967 Pongo abelii 93.13 0.00e+00 1078.00
IUUC-Pca-100765 Procavia capensis 89.31 0.00e+00 1021.00
IUUC-Pva-102807 Pteropus vampyrus 90.05 0.00e+00 1009.00
IUUC-Sha-107217 Sarcophilus harrisii 77.59 0.00e+00 1045.00
IUUC-Ssc-116227 Sus scrofa 84.19 0.00e+00 1093.00
IUUC-Tgu-116733 Taeniopygia guttata 70.13 0.00e+00 881.00
IUUC-Tru-117954 Takifugu rubripes 52.08 7.00e-176 610.00
IUUC-Tbe-127564 Tupaia belangeri 91.85 0.00e+00 1044.00
IUUC-Ttr-128996 Tursiops truncatus 90.09 0.00e+00 1031.00
IUUC-Xtr-132772 Xenopus tropicalis 63.28 0.00e+00 788.00
Created Date 25-Jun-2017

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